Diagnostic accuracy of C-reactive protein and white blood cell counts in the early detection of inflammatory complications after open resection of colorectal cancer: a retrospective study of 1,187 patients

C-reactive protein on postoperative day 3 as a predictor of infectious complications following gastric cancer resection

“…This is in contrast to CRP, which demonstrated consistent increases on PODs 2-4. In addition, both WBC count and body temperature failed to predict unfavorable outcomes as precisely as increases in CRP did [19,25,26,29,30]. The results of the present study are consistent with previous studies that highlighted the superiority of elevated CRP level over WBC count and body temperature in predicting the development of postoperative infectious complications.…”

“…There are several biochemical markers of the acute systemic inflammatory response, including CRP and WBC, and several recent studies have suggested a possible role for CRP in predicting the likelihood of infectious complications after gastrointestinal cancer surgery [19,[25][26][27][28][29][30][31], as shown in Table 3. These studies have proposed that an abnormally elevated CRP level on POD 3 or 4 or persistent elevation of CRP may be a useful predictor of infectious complications.…”

C-reactive protein and procalcitonin for the early detection of anastomotic leakage after elective colorectal surgery: Pilot study in 100 patients

“…Depending on the methodology of each study, the CRP level on Day 3 or Day 4 is the most appropriate measure. The corresponding threshold values vary from 19 to 12.5 respectively, depending on the day, with close agreement between the different series [12,13,[26][27][28]. However, PCT has been evaluated in colorectal surgery in only one study, where low numbers and the combination of colorectal surgery with aortic surgery make interpretation difficult and results inconclusive [19].…”

The Effect of Gender, Age and BMI on Postoperative C-Reactive Protein Levels After Major Abdominal Surgery

“…CRP is a well-established marker for inflammation since levels are determined only by their rate of synthesis, independent of diet, diurnal rhythm or organ function [11]. Several studies have assessed the use of CRP as a marker for anastomotic leakage [12][13][14] or septic complications [15][16][17]. The use of CRP has been researched in upper gastrointestinal (GI), hepatico-pancreatico-billiary (HPB) and colorectal resections with similar results [18][19][20].…”