Diagnostic Accuracy of Intestinal Fatty Acid Binding Protein for Acute Intestinal Ischemia: a Systematic Review and Meta-Analysis

Ding, Chun-Mei; Wu, Yongfeng; Liu, Xiaofei

doi:10.7754/clin.lab.2019.191139

Cited by 4 publications

(3 citation statements)

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“…In normal conditions, this protein is present in low amounts in the circulation, but upon damage to the intestinal barrier, it is released into the bloodstream. Increased I-FABP levels have been demonstrated in intestinal ischemia [ 39 ], celiac disease [ 40 ], necrotizing enterocolitis [ 41 ], and is hence a potential marker of intestinal injury and increased barrier permeability.…”

Section: Resultsmentioning

confidence: 99%

Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial

et al. 2022

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Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0–73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.

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Section: Resultsmentioning

confidence: 99%

Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial

et al. 2022

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“…In normal conditions, this protein is present in low amounts in the circulation, but upon damage to the intestinal barrier, it is released into the bloodstream ( 62 ). Increased I-FABP levels have been demonstrated in intestinal ischemia ( 63 , 64 ), celiac disease ( 65 ), necrotizing enterocolitis ( 66 ), etc.…”

Section: Methods To Assess Intestinal Permeabilitymentioning

confidence: 99%

The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

2021

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An increased intestinal permeability has been described in various gastrointestinal and non-gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability is relatively broad and includes not only an altered paracellular route, regulated by tight junction proteins, but also the transcellular route involving membrane transporters and channels, and endocytic mechanisms. Paracellular intestinal permeability can be assessed in vivo by using different molecules (e.g., sugars, polyethylene glycols, 51Cr-EDTA) and ex vivo in Ussing chambers combining electrophysiology and probes of different molecular sizes. The latter is still the gold standard technique for assessing the epithelial barrier function, whereas in vivo techniques, including putative blood biomarkers such as intestinal fatty acid-binding protein and zonulin, are broadly used despite limitations. In the second part of the review, the current evidence of the role of impaired barrier function in the pathophysiology of selected gastrointestinal and liver diseases is discussed. Celiac disease is one of the conditions with the best evidence for impaired barrier function playing a crucial role with zonulin as its proposed regulator. Increased permeability is clearly present in inflammatory bowel disease, but the question of whether this is a primary event or a consequence of inflammation remains unsolved. The gut-liver axis with a crucial role in impaired intestinal barrier function is increasingly recognized in chronic alcoholic and metabolic liver disease. Finally, the current evidence does not support an important role for increased permeability in bile acid diarrhea.

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“…Due to its small size, FABP rapidly leaks out of ischemic damaged necrotic cells leading to a rise in serum levels and is a useful biomarker for intestinal cell damage. (20)(21) . Increase in I-FABP has also been shown secondary to severe inflammatory conditions such as acute pancreatitis (23) .…”

Section: Potential Biomarkersmentioning

confidence: 99%

The role of citrulline, intestinal fatty acid–binding protein, and D-dimer as potential biomarkers in the diagnosis of internal herniation after Roux-en-Y gastric bypass

Zaigham

Regnér

Ekelund

et al. 2021

Surgery for Obesity and Related Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Diagnostic Accuracy of Intestinal Fatty Acid Binding Protein for Acute Intestinal Ischemia: a Systematic Review and Meta-Analysis

Cited by 4 publications

References 0 publications

Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial

Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial

The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

The role of citrulline, intestinal fatty acid–binding protein, and D-dimer as potential biomarkers in the diagnosis of internal herniation after Roux-en-Y gastric bypass

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