Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India

Kannan, R.; Rao, Suchetha; Mithra, Prasanna; Dhanashree, B; Baliga, Shantharam; Bhat, Kamalakshi G.

doi:10.1155/2018/7908148

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Analysis of serum pro-ADM levels in the present study revealed that the sepsis group had a significantly higher mean pro-ADM level compared with the control group (mean=35.09 versus 10.58, respectively; P<0.001). This result is in agreement with earlier studies, which reported higher levels of pro-ADM in neonates diagnosed with bacterial infection [11][12][15][16].…”

Section: Discussionsupporting

confidence: 94%

Value of Serum Pro-adrenomedullin in Diagnosis of Neonatal Sepsis

Samra

Elgawhary

Mohammed

2022

Fayoum University Medical Journal

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Neonatal sepsis remains one of the leading causes of morbidity and mortality, both among term and preterm infants [1]. Early diagnosis of neonatal sepsis is possible by measuring biomarkers of inflammation. Re-liable biomarkers for sepsis help not only early diagnosis of the condition, but also guide treatment by rapid initiation of antimicrobial therapy. That could avoid the over-use of therapeutic agents and improve the patient's prognosis [2-4].

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Section: Discussionsupporting

confidence: 94%

Value of Serum Pro-adrenomedullin in Diagnosis of Neonatal Sepsis

Samra

Elgawhary

Mohammed

2022

Fayoum University Medical Journal

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“…90% of neonates with increased ProADM died and 92.5% of neonates with decreased ProADM survived. The serial monitoring of ProADM levels had a significant role in predicting prognosis: indeed, a decrease in ProADM level by 10 pMol/mL was associated with a 99% probability of survival [19].…”

Section: Neonatal Sepsismentioning

confidence: 99%

The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review

Garazzino

Altieri

Denina

2019

Reports

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Sepsis is still related to high mortality and hospitalization rates in the paediatric population despite medical progress. Prompt recognition of sepsis and consequent initiation of an appropriate treatment are essential elements in securing a positive outcome in adults and children. In such scenario, various biomarkers have been studied to support the clinician in the diagnosis of severe infections, in the identification of patients at risk of progression towards sepsis as well as in the evaluation of the response to treatment. In children, the performance of C-reactive protein and procalcitonin has been largely investigated, whereas data on newer biomarkers of sepsis are scant. The aim of the present review is to summarise the available data on the use of pro-adrenomedullin in the paediatric age.

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“…Sensitivity for the diagnosis of sepsis was 93.3%, and specificity 86.7% [ 144 ]. However, as ProADM serum values are higher in preterm than in term babies, better prediction of EOS depends on the use of different cut-off levels according to GA (3.9 nmol/L in term neonates and 4.3 nmol/L in preterm babies) [ 96 , 145 ]. Better results have been reported when ProADM was used in combination with other markers [ 146 ].…”

Section: Biomarkers Presently Used In Clinical Practicementioning

confidence: 99%

Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going

Boscarino,

Migliorino,

Carbone

et al. 2023

Antibiotics

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Neonatal sepsis is a bacterial bloodstream infection leading to severe clinical manifestations frequently associated with death or irreversible long-term deficits. Antibiotics are the drug of choice to treat sepsis, regardless of age. In neonates, the lack of reliable criteria for a definite diagnosis and the supposition that an early antibiotic administration could reduce sepsis development in children at risk have led to a relevant antibiotic overuse for both prevention and therapy. The availability of biomarkers of neonatal sepsis that could alert the physician to an early diagnosis of neonatal sepsis could improve the short and long-term outcomes of true sepsis cases and reduce the indiscriminate and deleterious use of preventive antibiotics. The main aim of this narrative review is to summarize the main results in this regard and to detail the accuracy of currently used biomarkers for the early diagnosis of neonatal sepsis. Literature analysis showed that, despite intense research, the diagnosis of neonatal sepsis and the conduct of antibiotic therapy cannot be at present decided on the basis of a single biomarker. Given the importance of the problem and the need to reduce the abuse of antibiotics, further studies are urgently required. However, instead of looking for new biomarkers, it seems easier and more productive to test combinations of two or more of the presently available biomarkers. Moreover, studies based on omics technologies should be strongly boosted. However, while waiting for new information, the use of the clinical scores prepared by some scientific institutions could be suggested. Based on maternal risk factors and infant clinical indicators, sepsis risk can be calculated, and a significant reduction in antibiotic consumption can be obtained.

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Diagnostic and Prognostic Validity of Proadrenomedullin among Neonates with Sepsis in Tertiary Care Hospitals of Southern India

Cited by 7 publications

References 15 publications

Value of Serum Pro-adrenomedullin in Diagnosis of Neonatal Sepsis

Value of Serum Pro-adrenomedullin in Diagnosis of Neonatal Sepsis

The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review

Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going

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