Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

Liu, Gui‐Feng; Wang, Zongqiang; Zhang, Shuhua; Li, Xuefeng; Liu, Lin; Miao, Yingying; Yu, Shiying

doi:10.3892/ijmm.2018.3591

Cited by 3 publications

(6 citation statements)

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“…The TN subtype of BC has a higher histological grade and a worse prognosis compared with the other three subtypes, but its CEUS perfusion pattern lacks specificity and it may thus be confused with benign lesions. 39 The three cases of medullary carcinoma in this study were all TN subtype BCs. Previous studies found that the CEUS perfusion pattern of medullary carcinoma usually presents as regular morphology, with well-defined margins and homogenous enhancement.…”

Section: Discussionmentioning

confidence: 87%

“…CEUS perfusion parameters were found to correlate with vascular endothelial growth factor (VEGF) expression and predictors of poor prognosis, 21 in addition, it can provide excellent predictive value for high‐grade malignancy of BC and might help to determine appropriate therapeutic strategies 22 . Although previous studies have explored the correlation between CEUS characteristics and certain histopathological features of BC, 23,24 few studies have focused on the identification of BC molecular subtypes based on CEUS characteristics 25,26 . The current study thus aimed to explore the correlation between qualitative and quantitative CEUS characteristics and the different pathological molecular subtypes of BC.…”

mentioning

confidence: 99%

“…22 Although previous studies have explored the correlation between CEUS characteristics and certain histopathological features of BC, 23,24 few studies have focused on the identification of BC molecular subtypes based on CEUS characteristics. 25,26 The current study thus aimed to explore the correlation between qualitative and quantitative CEUS characteristics and the different pathological molecular subtypes of BC.…”

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confidence: 99%

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Association Between Contrast‐Enhanced Ultrasound Characteristics and Molecular Subtypes of Breast Cancer

Wen

Kong

Zhang

et al. 2021

J of Ultrasound Medicine

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Objective This study aimed to investigate the correlation between contrast‐enhanced ultrasound (CEUS) features and molecular subtypes of breast cancer (BC). Methods A total of 116 patients (116 lesions) with pathologically diagnosed BC who received conventional ultrasound and CEUS before surgery were enrolled in this study. BC molecular subtypes were identified by postoperative pathological and immunohistochemical analysis as Luminal A (LA), Luminal B (LB), HER2 (H2) over‐expression, and triple‐negative (TN). Qualitative and quantitative CEUS characteristics were analyzed by one‐way analysis of variance (continuous variables) or Pearson's χ2 test or Fisher's exact probability method (categorical variables). Results There were significant differences in enhancement speed and enhancement degree among the four subtypes (P < .05). The area under the curve (AUC), time to peak (TTP), and peak intensity (PI) differed among the four subtypes (P < .05). The AUC of the LA subtype (305.1 ± 188.4) was significantly smaller compared with the H2 (535.7 ± 222.0, P = .007) and TN subtypes (496.6 ± 254.7, P = .019). In addition, TTP was shorter in the H2 subtype (19.8 ± 4.9) compared with the other subtypes, and was significantly shorter than in the LA subtype (26.3 ± 7.2, P = .008) and LB subtype (23.1 ± 6.7, P = .036). The PI of the LA subtype (4.7 ± 2.3) was significantly lower than that of the LB (6.6 ± 2.3, P = .027), H2 (7.4 ± 2.2, P = .005), and TN subtypes (6.9 ± 2.6, P = .014). Conclusions CEUS features differed significantly among different molecular subtypes of BC. The enhancement patterns and parameters may be important predictive features of different subtypes of BC.

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Section: Discussionmentioning

confidence: 87%

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confidence: 99%

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confidence: 99%

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Association Between Contrast‐Enhanced Ultrasound Characteristics and Molecular Subtypes of Breast Cancer

Wen

Kong

Zhang

et al. 2021

J of Ultrasound Medicine

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“…The model's diagnostic accuracy was significantly better for patients >35 y, for maximum lesion diameter >20 mm, and for distance from the lesion's deep edge to the pectoralis major ≤3.05 mm. CEUS is a promising method for the accurate diagnosis of breast cancer and can optimize BI-RADS categorization (22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing the performance of a diagnostic model including contrast-enhanced ultrasound in 1023 breast lesions: comparison with histopathology

Chen

Tang

et al. 2019

Ann. Transl. Med.

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Background: We aimed to investigate the influence of patient and lesion characteristics on our diagnostic model for contrast-enhanced ultrasound (CEUS) of the breast, comparing its accuracy with that of histopathology.Methods: Conducting a study with eight medical centers, we compared 1,023 breast lesions categorized as BI-RADS 4 or 5 with the score from our newly-established CEUS-based diagnostic model, comparing the results with pathological outcomes. Univariate and multivariate logistic regression analyses were conducted to determine the influence of clinicopathological characteristics on the performance of this CEUS model.Results: Logistic regression analysis showed that patients' age, maximum lesion diameter, and distance from the lesion's deep edge to the pectoralis major were significant independent influencing factors. The model's diagnostic accuracy was greater for patients >35 y (P=0.005), for maximum lesion diameter >20 mm, and for distance from the lesion's deep edge to the pectoralis major ≤3.05 mm. There was no significant difference in accuracy between lesions with maximum lesion diameter 10-20 and <10 mm (P=0.393). Conclusions:The diagnostic performance of the proposed CEUS model for breast lesions is influenced by patients' age, maximum lesion diameter, and distance from the lesion's deep edge to the pectoralis major.Consideration of influencing factors is required to optimize clinical use of the CEUS model.

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“…Ayrıca, luminal B grubundaki ADCmean değeri, HER2 pozitif gruba göre anlamlı olarak daha yüksek bildirilmiştir (p<0.05). HER2 pozitif ve triple negatif gruplarla karşılaştırıldığında, luminal A ve luminal B grupları anlamlı olarak daha yüksek ADCmin değerleri göstermiştir (18) . DW görüntülemenin tümörün biyolojisi ve mikrostrüktürel özelliklerini hakkında bilgi sağladığı bildirilmiştir.…”

Section: Tartişma Dw Mr'da Yüksek Manyetik Alan Gücüne Sahipunclassified

Evaluation of the Relationship Between 3.0 Tesla Diffusion Tensor MR Imaging Parameters and Breast Cancer Subtypes

Ozal¹,

Gemici²,

İnci³

et al. 2019

IKSST

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Çalışmamızda meme kanseri subtipleri ile meme manyetik rezonans (MR) görüntülemede alınan diffüzyon tensor görüntüleme (DTG) parametrelerinden ortalama difüzyon (MD) ve fraksiyonel anisotropi (FA) değeri arasındaki ilişkinin araştırılmasını amaçladık. Yöntem: Çalışmamızda Eylül 2015 ve Şubat 2018 tarihleri arasında pre-operatif 3.0 Tesla kontrastlı meme MR ve DTG yapılan 101 meme kanseri olgusu (51.37±11.47 yaş aralığında) geriye dönük olarak tarandı. Bu hastalar histopatolojik olarak tanı almış invaziv meme kanseri olgularıydı. Histopatolojik olarak östrojen reseptörü (ER), HER2 (human epidermal growth factor receptor 2) overekspresyonu ve tümör boyutu bakıldı. Meme kanseri şu moleküler alt tiplere ayrıldı: Östrojen reseptör pozitif ve HER2 negatif grup (Luminal A, n=46), Östrojen reseptör pozitif ve HER2 pozitif grup (Luminal B, n=24), östrojen reseptör negatif ve HER2 pozitif grup (HER2 pozitif, n=13), östrojen reseptör negatif ve HER2 negatif grup (Triple negatif, n=18). Kolmogorov Smirnov, Kruskal Wallis H testleri ve Benforroni Düzeltmeli Dunn çoklu karşılaştırmalar testi ile istatistiksel analizler yapıldı. Bulgular: Luminal A, Luminal B, HER2 (+) ve triple negatif gruplarına göre yaş (p=0.959), kitle boyutu (p=0.162) ve FA (p=0.674) değerleri arasında anlamlı farklılık saptanmamıştır (p>0.05). Ancak luminal A, Luminal B, HER2 (+) ve Triple negatif grupları ile MD medyan değerleri arasında anlamlı farklılık olduğu saptandı. Saptanan bu anlamlı farklılığın kaynağını tespit edebilmek amacıyla Benforroni düzeltmeli Dunn Çoklu karşılaştırma testi yapılmıştır. Yapılan çoklu karşılaştırmalar sonucunda, Luminal A ve HER2(+) alt grup arasında MD değerleri anlamlı düzeyde farklı olduğu görüldü (p=0.038). Sonuç: Bu bulgular meme invaziv tümörlerinde ölçülen difüzyon tensor değerlerinin meme kanseri moleküler alt tiplerini öngörmek açısından anlamlı olabileceğini düşündürmektedir.

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Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

Cited by 3 publications

References 37 publications

Association Between Contrast‐Enhanced Ultrasound Characteristics and Molecular Subtypes of Breast Cancer

Association Between Contrast‐Enhanced Ultrasound Characteristics and Molecular Subtypes of Breast Cancer

Factors influencing the performance of a diagnostic model including contrast-enhanced ultrasound in 1023 breast lesions: comparison with histopathology

Evaluation of the Relationship Between 3.0 Tesla Diffusion Tensor MR Imaging Parameters and Breast Cancer Subtypes

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