Diagnostic Utility of Prostate Specific Antigen for Detection of Prostatic Lesions

Jasani, Jasmin; Patel, Himani; Gheewala, Bijol; Vaishnani, Hetal; Bhuva, Kaushik; Sancheti, Sankalp; Patel, Anand; Tandon, Rakesh

doi:10.7439/ijbar.v3i4.425

Cited by 14 publications

(14 citation statements)

References 24 publications

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“…This is in agreement with the mean age reported by multiple studies including Khant et al (66.9 ± 9.4 years), 10 Josephine (65.5 years), 11 and Lakhey et al (67.6 years)12 in Indian and Nepalese patients respectively. In comparison, Jasani and colleagues reported mean age of 57.77±4.86 years for patients with BPH and 65.82±5.6 years for patients with prostate cancer 13. In our study, BPH was diagnosed in 1676 (76.56%) patients, prostatitis in 133 (6.07%), Carcinoma in 378 (17.26%) and PIN in 02 (0.09%) patients only.…”

contrasting

confidence: 44%

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Samad¹,

Fayyaz²,

Siddiqa³

et al. 2019

JIMDC

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Background: Pathological changes that mainly affect prostate gland are prostatitis, benign prostatic hyperplasia (BPH) and cancerous lesions. Digital rectal examination (DRE), Transrectal Ultrasonography (TUS), and prostate specific antigen (PSA) followed by histopathological examination, are routinely used tests for diagnosis of prostate lesions. The aim of the present study is to determine the role of serum PSA levels in differentially diagnosing the different types of prostate lesions.Material and Methods: This retrospective (observational) study was conducted in Ibn-e-Sina Hospital Multan. Data of 2189 patients who were operated from 2007 to 2017 due to prostatic lesions were included in this analysis. Patients with BPH, prostatitis, prostate carcinoma and Prostatic Intraepithelial Neoplasia (PIN) were grouped according to serum PSA levels (ranging from 0 to >100 ng/ml) into five groups. Frequencies and percentages were calculated for different histopathological findings. Association of PSA levels with different histological patterns was determined with chi-square test with P-value < 0.05 taken as significant difference.Results: Mean age of patients was 62.45+10.64 years. On histopathology, BPH was diagnosed in 1676 (76.56%) patients, prostatitis in 133 (6.07%), carcinoma in 378 (17.26%) and PIN in 02 (0.09%) patients, respectively. Serum PSA levels of 4.01-10 ng/ml were found in 1050 (62.64%) BPH patients and in 59 (44.36%) prostatitis patients. Serum PSA levels of 10.01-20 ng/ml were found in only 40 (2.4%) BPH patients, 47 (35.33%) prostatitis patients, 22 (5.82%) carcinoma patients and in 1 (50.0%) PIN patient. Serum PSA levels of 20.01-100 ng/ml were found in 32 (1.9%) BPH patients, 11 (8.27%) prostatitis patients, 302 (79.89%) carcinoma patients, and in 1 (50.0%) PIN patient. Serum PSA levels of >100 ng/ml were absent in patients with BPH and PIN, and present in 1 (0.75%) prostatitis and 54 (14.28%) carcinoma patients.Conclusion: Benign prostatic hyperplasia was the commonest lesion in our patients (76.56%) with serum PSA levels >10 ng/ml reported in all patients with prostate carcinoma and prostatic intraepithelial neoplasia (PIN) patients.

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contrasting

confidence: 44%

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Samad¹,

Fayyaz²,

Siddiqa³

et al. 2019

JIMDC

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“…Electrolyte imbalance has been severally observed as the commonly identified complication in severe cases of malaria. Electrolyte imbalance acts as an indicator for the level of disease virulence due to its close association with the severe P. falciparum and P. vivax malaria (16). In this study, blood samples were used for the evaluation of electrolytes in malaria patients and healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in Na level can result in several health conditions (17).Various literature shows reports of increased vasopressin(ADH) secretion which either appropriately or inappropriately is a key factor in the reduced level of sodium in malaria, as sodium is able to gain entry into the infected cells and cause loss of blood (18). Hyponatraemia has been identified as a common outcome of malaria (16). Ikekpeazu et al also reported a significant lowering of sodium and Potassium levels in malaria infection (20).…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Prevalence of Malaria Infection and Significant Spread of Electrolyte Variation in Malaria Patients: Within and Outside Limit Analysis

Ndako¹,

Okolie²,

Dojumo³

et al. 2020

Preprint

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Background: Malaria is one of the most common diseased conditions across most developing countries caused by one of four species of Plasmodium. P. falciparum and P.vivax are the main agents responsible for malaria in Nigeria. Malarial infection has been shown to be associated with abnormalities in fluids, electrolytes and acid base balances. Electrolyte imbalance and mineral disturbances are majorly identified clinical symptoms in various infectious diseases including malaria. Electrolyte imbalance in malarial infection is capable of enhancing disease severity. The aim of this study was to investigate the effects of malarial infection on electrolytes parameters. Methods: Finger prick blood samples, Thick and Thin Giemsa-stained blood smears, were collected from 100 malaria-suspected individuals representing all age groups. The Giemsa-stained blood smears were examined microscopically. Demographic information was obtained using structured questionnaires. The electrolytes levels (Na, K, Cl- and HCO3-) in malarial patients were analyzed using standard procedures, Pearson's Correlation Coefficient correlation technique was used to investigate the relationship, and the strength of association between the variables. Results: The mean bound of patients’ sodium level was observed to fall within the specified normal limits of 125mmol/L – 145mmol/L; except for positive malaria patients belonging to the MP-(++) which will fall below the 125mmol/L (i.e. 126.25mmol/L – 1.77mmol/L = 124.48mmol/L). The spread of the sodium data taken from the patients were observed to fall within the normal limits leaving only the boxplot’s lower whisker out, that is, observations falling within the first quartile, except for MP-(++) patients with observations in the first to second quartile spreading outside the normal lower limit, in contrast for the negative tested patients, the box and its whiskers were almost engulfed within the normal limits. Conclusion: In our study we found that Plasmodium falciparum altered more in electrolytes parameters than Plasmodium vivax. The biochemical markers can be used as biomarkers to confirmation of malaria. This study discovered a significant linear relationship based on the Pearson product-moment correlation between creatinine and urea, potassium and chloride, potassium and creatinine, potassium and urea. The mean sodium and chloride level of positive malaria [MP-(++)] patients were observed to fall outside the normal limit.

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“…Patients with a PSA value greater than 4 ng/mL, irrespective of DRE results, generally undergo biopsy. 9 Aims and Objectives (i) To study prevalence of distribution of various prostatic lesions, in the region of Dakshina Kannada (Karnataka). (ii) To evaluate the utility of PSA assay as a method of investigation in diagnosis of prostatic lesions.…”

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confidence: 99%

Utility of Prostate Specific Antigen in the Diagnosis of Various Prostatic Lesions

Shashidhar¹,

Shariff²

2016

jemds

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BACKGROUNDCarcinoma of the prostate is the most common internal malignancy among men in the United States and 10 th common malignancy in India. It accounts for 33% of all malignant tumours in men and responsible for 9% of all deaths due to cancer. Prostate specific antigen (PSA), a glycoprotein serine protease, was first identified by Wang et al in 1979. Prostate specific antigen (PSA) is a substance produced exclusively by certain cells within the male prostate gland. PSA is the most useful tumour marker in diagnosis and first line test in screening.The aims of this study were-1. To evaluate the utility of PSA assay as a method of investigation in diagnosis of prostatic lesions. 2. To correlate morphological types with serum PSA levels.

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Diagnostic Utility of Prostate Specific Antigen for Detection of Prostatic Lesions

Cited by 14 publications

References 24 publications

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Relationship Between Prevalence of Malaria Infection and Significant Spread of Electrolyte Variation in Malaria Patients: Within and Outside Limit Analysis

Utility of Prostate Specific Antigen in the Diagnosis of Various Prostatic Lesions

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