Diagnostic Value of Contrast-Enhanced Spectral Mammography for Screening Breast Cancer: Systematic Review and Meta-analysis

Zhu, Xiao Dong; Huang, Jian; Zhang, Kun; Xia, Longjie; Feng, Lan; Yang, Ping; Zhang, Mengya; Xiao, Wei; Lin, Hui‐Xia; Yu, Yinghua

doi:10.1016/j.clbc.2018.06.003

Cited by 59 publications

(47 citation statements)

References 47 publications

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“…Both CE-MRI and CEM have the advantage of providing morphological and functional information as they depend on neovascularity and angiogenesis of lesions [2].…”

Section: Discussionmentioning

confidence: 99%

“…Accurate diagnosis and characterization of breast lesions have an essential role in the management and improved prognosis of breast cancer [2,3]. CE-MRI is used nowadays as a problem-solving tool and as an adjunct to sonomammography in women at high risk or those with extremely dense breasts [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, MRI is a relatively expensive study that necessitates at least 30 to 40 min to acquire images and is not equally accessible to all women [2]. DCE-MRI is accused of having low specificity and being not recommended in the assessment of microcalcifications [7].…”

Section: Introductionmentioning

confidence: 99%

“…Contrast-enhanced mammography (CEM) is one of the relatively novel imaging modalities. CEM is a relatively easy feasible study with high sensitivity and low cost [2]. It provides low-energy images comparable to mammographic images and post-contrast recombined images to evaluate tumor neovascularity [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Can contrast-enhanced mammography replace dynamic contrast-enhanced MRI in the assessment of sonomammographic indeterminate breast lesions?

Kamal

Hanafy

Mansour

et al. 2020

Egypt J Radiol Nucl Med

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Background: Dynamic contrast-enhanced MRI of the breast has been used for several years in the assessment of indeterminate mammographic findings. Contrast-enhanced mammography is a relatively novel imaging technique that has shown comparable sensitivity and specificity to MRI. Contrast-enhanced mammography is a relatively easy feasible study with high sensitivity and low cost. Our aim was to assess the feasibility of replacing dynamic contrastenhanced (DCE)-MRI by contrast-enhanced mammography in the assessment of sonomammographic indeterminate lesions (BIRADS 3 and 4). Results: The study included 82 patients with 171 breast lesions. They all performed contrast-enhanced mammography and dynamic contrast-enhanced MRI. DCE-MRI sensitivity and NPV were significantly higher than those of contrast-enhanced mammogram (CEM). The overall accuracy of MRI was better than that of CEM; however, no statistically significant difference could be detected. Conclusion: Contrast-enhanced mammography and dynamic contrast-enhanced MRI improved the characterization of breast lesions. CEM showed slightly lower sensitivity and accuracy compared to MRI; however, because of being relatively easy, available, cheap, and acceptable by women, CEM can replace DC-MRI as a problem-solving tool in the characterization of indeterminate breast lesions.

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“…Both CE-MRI and CEM have the advantage of providing morphological and functional information as they depend on neovascularity and angiogenesis of lesions [2].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Can contrast-enhanced mammography replace dynamic contrast-enhanced MRI in the assessment of sonomammographic indeterminate breast lesions?

Kamal

Hanafy

Mansour

et al. 2020

Egypt J Radiol Nucl Med

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“…Although two meta-analyses and one systematic review on CESM have already been published [ [21] , [22] , [23] ], over the years the CESM technology kept improving and several new studies on CESM appeared in the literature, reflecting the interest in the new technique. Our purpose is to systematically evaluate the diagnostic accuracy of CESM in women with clinical and/or radiological suspicion of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of contrast-enhanced spectral mammography for breast lesions: A systematic review and meta-analysis

Suter¹,

Pesapane

Agazzi

et al. 2020

The Breast

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Breast cancer diagnosis and staging is based on mammography, ultrasound, and magnetic resonance imaging (MRI). Contrast enhanced spectral mammography (CESM) has gained momentum as an innovative and clinically useful method for breast assessment. CESM is based on abnormal enhancement of neoplastic tissue compared to surrounding breast tissue. We performed a systematic review of prospective trial to evaluate its diagnostic performance, following standard PRISMA-DTA. We used a bivariate random-effects regression approach to obtain summary estimates of both sensitivity and specificity of CESM. 8 studies published between 2003 and 2019 were included in the meta-analysis for a total of 945 lesions. The summary area under the curve obtained from all the study was 89% [95% CI 86%–91%], with a sensitivity of 85% [95% CI 73%–93%], and a specificity of 77% [95% CI 60%–88%]. With a pre-test probability of malignancy of 57% a positive finding at CESM gives a post-test probability of 83% while a negative finding a post-test probability of 20%. CESM shows a suboptimal sensitivity and specificity in the diagnosis of breast cancer in a selected population, and at present time, it could be considered only as a possible alternative test for breast lesions assessment when mammography and ultrasound are not conclusive or MRI is contraindicated or not available.

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Interpretation of Contrast-Enhanced Mammography

Lobbes

2019

Contrast-Enhanced Mammography

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Diagnostic Value of Contrast-Enhanced Spectral Mammography for Screening Breast Cancer: Systematic Review and Meta-analysis

Cited by 59 publications

References 47 publications

Can contrast-enhanced mammography replace dynamic contrast-enhanced MRI in the assessment of sonomammographic indeterminate breast lesions?

Can contrast-enhanced mammography replace dynamic contrast-enhanced MRI in the assessment of sonomammographic indeterminate breast lesions?

Diagnostic accuracy of contrast-enhanced spectral mammography for breast lesions: A systematic review and meta-analysis

Interpretation of Contrast-Enhanced Mammography

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