Diagnostik und Therapie der LASIK-induzierten neurotrophen Epitheliopathie

Breil, P.; Frisch, L.; Dick, H. Burkhard

doi:10.1007/pl00007117

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…According to our knowledge, association between the keratorefractive surgery and presence of DF has not been studied so far. The keratorefractive surgery could result in damage to the corneal nerve, which could cause the neurotrophic keratopathy 31 . www.nature.com/scientificreports/ Besides, the conjunctival goblet cells might also be damaged leading to decreased mucin secretion 32 .…”

Section: Discussionmentioning

confidence: 99%

The prevalence of ocular Demodex folliculorum in 2253 young males

Yan

Wang

et al. 2022

Sci Rep

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To investigate the prevalence and influencing factors of Demodex folliculorum (DF) in the eyelashes of healthy young males. An epidemiological cross-sectional prevalence study was conducted. We conducted visual acuity, eye-related examination, eyelash microscopic examination and DF count of recruits in Fujian Province in 2019. The presence of DF was analyzed according to age, keratorefractive surgery, annual household income, educational level, long-term residence, sleep time, time of using electronic products, smoking and drinking habit. A total of 2253 healthy young males (aged 17–24 years) were studied for the presence of DF within eyelash follicles. The total prevalence of DF was 20.73% in our study. Subjects with history of keratorefractive surgery had a statistically significant increase in the prevalence of DF (P < 0.001). The prevalence of DF was higher in subjects with ocular symptoms than in those without symptoms (P < 0.05). Factors such as the educational level and so on we analyzed had no significant correlation with the prevalence of DF (all P > 0.05). According to the multivariate logistic regression analysis, the history of keratorefractive surgery was the risk factors of DF infection (P < 0.001), and the risk of infection was 1.437 times higher in the population with the history of keratorefractive surgery than in the population without. There was no correlation between ocular discomfort and DF infection (P > 0.05). The prevalence of DF in eyelash follicles in healthy young males was relatively high. The history of keratorefractive surgery was an important risk factor for the infection.

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Section: Discussionmentioning

confidence: 99%

The prevalence of ocular Demodex folliculorum in 2253 young males

Yan

Wang

et al. 2022

Sci Rep

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“…Tran-section of the sub-basal nerve plexus and deep stromal nerve during flap creation are contributory to the main pathophysiology. 8 Although corneal sensation can return to normal value from weeks to months, 4 sub-basal nerve fiber density has been reported not to return to preoperative levels by 2 years in confocal microscopy studies. 9 Prolonged corneal nerve regeneration is to blame in recalcitrant LINE.…”

Section: Discussionmentioning

confidence: 99%

Autologous serum therapy in recalcitrant laser-assisted in situ keratomileusis-induced neurotrophic epitheliopathy

Lin

Chang³

et al. 2015

Taiwan Journal of Ophthalmology

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Background/Purpose:To evaluate the efficacy of autologous serum eye drops for patients with recalcitrant laser-assisted in situ keratomileusis (LASIK)-induced neurotrophic epitheliopathy (LINE) unresponsive to conventional treatment, and to determine the possible predisposing risk factors of these patients.Methods:We enrolled 10 consecutive patients (20 eyes) undergoing femtosecond-assisted myopic LASIK surgery presenting with recalcitrant LINE for > 1 year. Another 340 patients (713 eyes) receiving femtosecond-assisted myopic LASIK without recalcitrant LINE were set as controls. Possible risk factors associated with recalcitrant LINE were investigated. Twenty percent autologous serum treatment was prescribed to 20 eyes. The efficacy of autologous serum was assessed with ocular surface conditions, tear function, and the change of best-corrected visual acuity.Results:Age older than 30 years [odds ratio (OR) = 7.74; 95% confidence interval (CI), 1.74–34.50], flap thickness < 110 μm (OR = 3.47; 95% CI, 1.22–9.73), and a flap diameter < 8.5 mm (OR = 5.38; 95% CI, 1.95–14.85) pose higher risks in femtosecond laser-assisted myopic LASIK. All eyes (100%) achieved remission after autologous serum treatment. The visual acuity before treatment was 0.49 ± 0.41 in LogMAR, and the visual acuity after treatment was 0.14 ± 0.22 in LogMAR. Time to achieve remission was 8.26 ± 11.87 weeks. Mean relapse-free survival after discontinuing autologous serum was 47 weeks.Conclusion:Risk factors of recalcitrant LINE in femtosecond laser-assisted myopic LASIK were identified as older age, a thinner flap (<110 μm), and a small flap diameter (<8.5 mm). Autologous serum eye drops can effectively improve corneal surface conditions and postoperative visual acuity.

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“…8,11 Suppression of tear production is an alternative mechanism that may occur as a direct result of corneal overstimulation and not as a consequence of LASIK-induced corneal denervation, as previously considered. 50 The cornea-to-lacrimal gland feedback mechanism has been proposed as a cause for the dry eye that occurs after LASIK procedures and other forms of corneal trauma. [2][3][4] Our finding that corneal injury induces widespread gene suppression in the lacrimal gland may provide genetic evidence to support this mechanism.…”

Section: Discussionmentioning

confidence: 99%