Diametric measurement of foveal avascular zone in healthy young adults using optical coherence tomography angiography

Hussain, Nazimul; Hussain, Anjli

doi:10.1186/s40942-016-0053-8

Cited by 25 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This noninvasive technology is finding increasing acceptance in clinical practice and a growing field of clinical research is focusing on the microvascular changes evaluated using OCT-A in different retinal diseases [ 2 , 4 ]. The FAZ area has been evaluated using OCT-A in healthy subjects [ 11 ], in patients with systemic diseases [ 3 , 8 , 14 ] and in subjects with different retinal diseases including retinal vein occlusion, diabetic retinopathy, retinitis pigmentosa, sickle cell disease and Stargardt disease, after macular hole surgery and in patients with Behçet uveitis [ 6 , 7 , 15 – 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, this also means that phenomena such as pooling or staining do not occur in OCT-A, since there is no dye leaking from pathological microvasculature. This allows better visualization of the whole microvasculature including the foveal avascular zone (FAZ) in healthy subjects and also facilitates investigation of retinal pathologies such as diabetic retinopathy and the examination of eyes with retinal neovascularisations [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Repeatability, reproducibility and agreement of foveal avascular zone measurements using three different optical coherence tomography angiography devices

Mihailovic¹,

Brand²,

Lahme³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

PurposeTo evaluate the repeatability, the reproducibility and the agreement of foveal avascular zone (FAZ) measurements using three different optical coherence tomography angiography (OCT-A) devices.ProceduresThis prospective study included 24 eyes of 24 healthy volunteers. OCT-A imaging was performed using RTVue XR Avanti, Canon OCT-HS100 and Spectralis OCT-A. Repeated measurements were performed under the same conditions on two separate days, and the area of the FAZ was determined and analyzed using the above devices.ResultsAll three devices showed a high ICC and there was no significant difference between the ICCs (pairwise comparison) of the three devices (Optovue–Canon (p = 0.66); Canon–Heidelberg (p = 0.21); Heidelberg–Optovue (p = 0.37). Agreement analysis of the three devices revealed a significant elevation of FAZ area values with the Heidelberg device and a slight underestimation of the FAZ area with the Canon device. Nevertheless, overall we found a high level of agreement between all of the three devices (ICC ≥ 0.958 (0.905–0.982)).ConclusionsGood reproducibility and repeatability were observed for all three devices. However, the agreement analysis revealed slight, but significant differences, which might limit alternating use of these devices for clinical research and follow-up examinations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Repeatability, reproducibility and agreement of foveal avascular zone measurements using three different optical coherence tomography angiography devices

Mihailovic¹,

Brand²,

Lahme³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Various studies have characterized the FAZ size and shape in healthy people using OCTA. 10 , 11 , 12 , 13 All of these studies used the manufacturer's default settings for slab segmentation into SCP and DCP. However, Spaide and Curcio recently pointed out that the default settings of the commonly used OCTA manufacturers incorrectly segment the central macula of normal eyes.…”

Section: Discussionmentioning

confidence: 99%

Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults

Rommel

Siegfried²,

Kurz

et al. 2018

Journal of Current Ophthalmology

View full text Add to dashboard Cite

PurposeTo evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA).MethodsParticipants with healthy retinas were recruited, and 5 × 5 mm OCTA images were acquired using the Canon HS-100 Angio eXpert module. FAZ size was measured in automatically (AS, manufacturer-based) and manually (MS, anatomical-based) segmented OCTA slabs by two experienced graders. FAZ dimensions, inter-rater agreement, and correlation to demographic and retinal parameters were evaluated.ResultsA total of 38 eyes from 20 healthy adult subjects were included in this cross-sectional study. While in AS slabs, the FAZ in the SCP was smaller than in the DCP, in MS images, it was the opposite. MS had a relevant impact on inter-rater agreement of FAZ measurements in the SCP. The FAZ area in both plexus correlated inversely with the central retinal thickness (CRT), irrespective of the segmentation applied. Furthermore, an enlargement of FAZ size in the DCP with increasing age was found. Finally, the FAZ in female participants was significantly larger than in their male counterparts, regardless of the evaluated plexus and chosen segmentation.ConclusionsCorrect anatomical slab segmentation has a significant impact on FAZ size measurements. Not adjusting the segmentation boundaries represents a significant source of error for measuring FAZ area and confounds comparisons across studies as well as OCTA devices.

show abstract

“…The most significant difference, even though it is hardly notable, is visible in the bright white dots in the top layers of the retina. Based on en face reconstructions of our data sets and OCT angiography images from literature [59], we identify these structures as fine blood vessels. For a quantitative analysis, we determined the point spread function of a specular reflex at the interface of the retina and vitreous body to evaluate the actual axial resolution of our retinal images [60].…”

Section: Oct Imagingmentioning

confidence: 99%

High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates

Kolb

Pfeiffer

Eibl

et al. 2017

Biomed. Opt. Express

View full text Add to dashboard Cite

We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz  =  834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 µm axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 µm axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.

show abstract

Diametric measurement of foveal avascular zone in healthy young adults using optical coherence tomography angiography

Cited by 25 publications

References 14 publications

Repeatability, reproducibility and agreement of foveal avascular zone measurements using three different optical coherence tomography angiography devices

Repeatability, reproducibility and agreement of foveal avascular zone measurements using three different optical coherence tomography angiography devices

Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults

High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates

Contact Info

Product

Resources

About