1949
DOI: 10.1111/j.1651-2227.1949.tb17908.x
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Diaplacental Infection of the Foetus With the Virus of German Measles Despite Immunity of the Mother: Analogous Observations in Smallpox

Abstract: Summary The problem of the transmission of german measles to the foetus of a mother immune to the disease is discussed. The occurrence of transmission is already established (Warkany). Analogous observations in smallpox have been published. The literature of the latter is reviewed. The consequence of such transmissions in different virus diseases constitutes a warning that a pregnant mother, even if she has had german measles in childhood or is herself immune to german measles without any previous history ther… Show more

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Cited by 26 publications
(3 citation statements)
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“…More recent prospective studies agree with Lundström's figures. 10 The above figures by Lundström sug¬ gest that previous history of the disease is not sufficient to protect the fetus, and re¬ ports by Schick,7 and Coffey and Jessop,1 support this impression. The latter reported a series of 75 cases in Dublin, Ireland, and noted that women who were exposed to, but did not develop, rubella produced offspring with anomalies at a rate that was 2.5 times as great as that seen in the general popu¬ lation.…”
Section: Incidencementioning
confidence: 64%
See 1 more Smart Citation
“…More recent prospective studies agree with Lundström's figures. 10 The above figures by Lundström sug¬ gest that previous history of the disease is not sufficient to protect the fetus, and re¬ ports by Schick,7 and Coffey and Jessop,1 support this impression. The latter reported a series of 75 cases in Dublin, Ireland, and noted that women who were exposed to, but did not develop, rubella produced offspring with anomalies at a rate that was 2.5 times as great as that seen in the general popu¬ lation.…”
Section: Incidencementioning
confidence: 64%
“…Schick" offered an explanation for the increased incidence of congenital anom¬ alies despite the presence of immunity in the mother by comparing rubella to small¬ pox. He pointed out that newborns infected with smallpox have been observed in preg¬ nant women exposed to smallpox who had previously been successfully vaccinated and Exposure to rubella during first 4 months of pregnancy without development of the disease in women with previous history of rubella 11 Exposure to rubella during first 4 months of pregnancy without development of the disease in women with¬ out previous history of rubella 7 Exposure to rubella after the 4th month of pregnancy 6 Control series 6 humoral immunity the virus that invades the blood stream is killed immediately.…”
Section: Incidencementioning
confidence: 99%
“…Maternal variola during pregnancy can cause abortion, stillbirth, or neonatal death (Plotz, 1965), and even the infants of healthy immune mothers may be infected in utero and may die from congenital variola (Schick, 1949;Rao, Ratnakannan, Balasubramaniam, and Gopalan, 1954). A similar situation exists with rubella (Schick, 1949).…”
mentioning
confidence: 99%