Diastase induced green synthesis of bilayered reduced graphene oxide and its decoration with gold nanoparticles

Maddinedi, Sireesh Babu; Mandal, Badal Kumar; Patil, Sagar H.; Andhalkar, Vaibhav Vilas; Ranjan, Shivendu; Dasgupta, Nandita

doi:10.1016/j.jphotobiol.2016.12.008

Cited by 72 publications

(7 citation statements)

References 31 publications

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“…This makes it very challenging to develop nano-based drugs or targeting moieties as the information pertaining to it is limited. Usually, drugs are tested on animal models like rats, mice or rabbits, but the same physiology and drug interaction is hardly applicable to the human body [94][95][96][97][98][99]. This increases the chances of failure of the drug or might result in the drug reaching untargeted sites.…”

Section: Challengesmentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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The application of nanotechnology in medicine, diagnostics, therapeutics, drug delivery, etc. in order to overcome the limitations faced by these fields has already been established. Anaemia and osteoporosis are two of the most widely prevalent iron and calcium deficiency diseases among women. Conventional drugs for both have their inherent limitations which can be overcome by nanotechnology. Nanonization of drugs has been established as a very efficient way to enhance the bioavailability and absorption of the drug in the gastrointestinal tract. In addition to this, encapsulation of drugs in solid lipid nanoparticles is also employed to increase the stability of the drug in the gastrointestinal tract and to facilitate its controlled release. Nanotechnology is also applied in bone tissue engineering to prepare bone grafts for bone injury. Nanotechnology-based bone grafts have shown to possess enhanced mechanical properties and better biocompatibility and osteoconduction than the conventional bone grafts. This review article highlights the research trends and challenges of nanotechnology based drugs to combat iron deficiency anaemia and osteoporosis. This review outlines the recent research trends in nano-drugs and touches on issues concerning the market, industries and patents pertaining to drugs for anaemia and osteoporosis. To provide the safety and risk factors of nanomaterials, we have briefly highlighted the toxicological aspects of nanomaterials used in drugs.

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Section: Challengesmentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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“…In addition, adsorption of stretching -OH was attribute to the monitored broad band at 3452 cm −1 [38]. Moreover, the stretching vibration mode of other groups such as C-O was detected at 1400 cm −1 and C-H was detected at 2938 and 2852 cm −1 [39]. Further, modification of amine groups (AGO); also the GO bands were detected at 1723 cm −1 .…”

Section: Functional Groups Investigationmentioning

confidence: 92%

Fabrication of Multi-functionalized Graphene Oxide Doped Alginate Hybrid Spheres for Enhanced Fluoride Adsorption

Jeyaseelan

Viswanathan

Naushad

et al. 2021

J Inorg Organomet Polym

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In this present investigation, amine functionalized graphene oxide (AGO) doped on alginate (Alg) polymeric matrix gives AGO@Alg hybrid spheres was developed to explore its potential towards fluoride retention. The vital characterization techniques namely FTIR, TGA, SEM and XPS analysis of AGO@Alg hybrid spheres were acquired to identify its physicochemical properties. The liable parameters for fluoride adsorption onto AGO@Alg hybrid spheres were optimized in a batch mode to attain enhance defluoridation capacity (DC).The prepared AGO@Alg hybrid spheres follow the electrostatic interaction mechanism on defluoridation. The adsorption isotherms (Fruendlich, Langmuir, Temkin and Dubinin-Radushkevich (D-R) models), kinetics (reaction and diffusion based models) and thermodynamic parameters (ΔS°, ΔG° and ΔH°) were surveyed at 303, 313 and 323 K. To lessen the costeffectiveness of AGO@Alg hybrid spheres the recyclability test was conducted. The aptness of AGO@Alg hybrid spheres was also scrutinized for the fluoride contaminated field sample collected from fluoride endemic village.

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“…17 To further reduce the toxic effects, researchers have tried to synthesize nanoparticles by the green method. [18][19][20][21][22][23] Nonetheless, the toxicity of Se is still not negligible in the treatment. With these considerations, Liu and colleagues fabricated porous Se@SiO 2 nanocomposites with an average diameter of ~55 nm.…”

Section: Introductionmentioning

confidence: 99%

A Selenium Nanocomposite Protects the Mouse Brain from Oxidative Injury Following Intracerebral Hemorrhage

Yang¹,

Deng²,

Wang³

et al. 2021

IJN

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Background Intracerebral hemorrhage (ICH) is a common neurological crisis leading to high mortality and morbidity. Oxidative stress-induced secondary injury plays a critical role in neurological deterioration. Previously, we synthesized a porous Se@SiO 2 nanocomposite and identified their therapeutic role in osteonecrosis of the femoral head. Whether this nanocomposite is neuroprotective remains to be elucidated. Methods A porous Se@SiO 2 nanocomposite was synthesized, and its biosafety was determined using a CCK-8 assay. The neuroprotective effect was evaluated by TUNEL staining, and intracellular ROS were detected with a DCFH-DA probe in SH-SY5Y cells exposed to hemin. Furthermore, the effect of the nanocomposite on cell apoptosis, brain edema and blood–brain barrier permeability were evaluated in a collagenase-induced ICH mouse model. The potential mechanism was also explored. Results The results demonstrated that Se@SiO 2 treatment significantly improved neurological function, increased glutathione peroxidase activity and downregulated malonaldehyde levels. The proportion of apoptotic cells, brain edema and blood–brain barrier permeability were reduced significantly in ICH mice treated with Se@SiO 2 compared to vehicle-treated mice. In vitro, Se@SiO 2 protected SH-SY5Y cells from hemin-induced apoptosis by preventing intracellular reactive oxygen species accumulation. Conclusion These results suggested that the porous Se@SiO 2 nanocomposite exerted neuroprotection by suppressing oxidative stress. Se@SiO 2 may be a potential candidate for the clinical treatment of ICH and oxidative stress-related brain injuries.

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Diastase induced green synthesis of bilayered reduced graphene oxide and its decoration with gold nanoparticles

Cited by 72 publications

References 31 publications

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Fabrication of Multi-functionalized Graphene Oxide Doped Alginate Hybrid Spheres for Enhanced Fluoride Adsorption

A Selenium Nanocomposite Protects the Mouse Brain from Oxidative Injury Following Intracerebral Hemorrhage

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