Die Arzneimittel-Synthese

Carbamate Herbicides, Relative Herbicidal and Growth Modifying Activity of Several Esters of N-Phenylcarbamic Acid

“…(1) a nuclear ring system, active interfacially, (2) an unsaturated linkage in this ring located adjacent to a side chain, (3) a side chain, (4) a carboxyl group, or carboxyl precursor, in the side chain at a position removed from the ring by at least one carbon atom, and…”

“…It is concluded that alterations of the structure of this portion of the molecule can exert profound effects upon the biological activity of such compounds. THE PHYSIOLOGICAL EFFECTS of esters of carbamic acid and A7-substituted carbamic acids, such as ethyl carbamate (urethan) and ethyl Ar-phenylcarbamate (phenylurethan), on both animal and plant life were first reported nearly 25 years ago (2,9). Descriptions of additional experiments to determine the effects of this class of compounds on plants have appeared sporadically during the second decade of this period and with increasing frequency in recent years.…”

Possible Sedative Agents. II. Some Substituted Acetoacetamides

“…Introduction 01 an a-halogen (SD-34, 36, and 39) is not beneficial, as is frequently the case with simple aliphatic amides. Although Frankel (7) report5 sedative and analgesic properties for several aliphatic acyl-p-phenetidides, oiz. lactyl-fi-phenetidide (Lactophenin), dipropylacet-p-phenetidide, diethylmalonyl-p-phenetidide, and dipropylmalonyl-fi-phenetidide, none of the closely related acetoacet-p-phenetidides (SD-15, 18, 21, 23, 2.5, and 36) possess sedative properties, and analgesia was observed with only one (SD-15).…”

Some Esters of Dialkylamino Methanols*1

“…In recent years numerous compounds have been made (1) by modifying the structure of procaine. These have been produced with the hope of discovering a better local anzesthetic and, to a less extent, in order to obtain more information about the relation between constitution and anaesthetic action.…”