Die Ausscheidung der tetra- und hexahydrierten Metaboliten des Cortisols im Urin unter Applikation von ACTH

Adrenocortical Stimulation Tests with ACTH: Developments and Changes of a Diagnostic Procedure

“…Such procedures rendered possible a clear differentiation between primary and secondary adrenal insufficiency. It seems to be quite remarkable that most striking elevations of urinary steroid excretion have been observed in measuring cortisol [65] or uncon jugated 11-or 17-hydroxycorticosteroids [27,28,119], Several attempts have been made to displace tedious ACTH infusion by intramuscular administration of the hormone. But usually multiple injections had been necessary to obtain a clear increase of 17-keto-or 17-hydroxy corticosteroids.…”

C-20-Reduced Metabolites of Cortisol in Normal Human Urine

“…In some pathological states, the urinary excretion of the latter metabolites might be expected to be increased. This however, has not been sufficiently discussed in the literature (Romanoff et al, 1959(Romanoff et al, , 1961Husmann and Kleinfelder, 1964;Kleinfelder and Husmann, 1965), because of the difficulties in the determination procedures related to their high polarity.…”