Die endogene Kreatininclearance beim nierenkranken Menschen

Creatinine clearance in renal disease. A reappraisal

“…Brod and Sirota (1948) In direct contrast with the above studies, endogenous creatinine clearance was found to differ so significantly from inulin clearance in a series of nine patients with renal disease or congestive heart failure that it could not be considered a satisfactory measure of glomerular filtration rate (Miller et al, 1952). Similarly, the ccreatinine/cinulin ratio in 14 patients with renal disease was found to be highly variable and unpredictable (Doering et al, 1953). In six patients with renal disease the creatinine/inulin clearance ratios ranged between 0 97 and 2 37 (Berlyne et al, 1964), and these workers concluded that the ratio was Materials and Methods Three hundred and eight simultaneous determinations of endogenous creatinine, inulin, and para-aminohippurate clearance were performed in 250 persons over the past six years.…”

“…Similarly, the ccreatinine/cinulin ratio in 14 patients with renal disease was found to be highly variable and unpredictable (Doering et al, 1953). In six patients with renal disease the creatinine/inulin clearance ratios ranged between 0 97 and 2 37 (Berlyne et al, 1964), and these workers concluded that the ratio was not predictable and that the endogenous creatinine clearance was not a reliable measure of glomerular filtration rate in patients with renal disease.…”

“…Other investigators (Brod and Sirota, 1948;Hare et al, 1949;Smith, 1951 ;Doering et al, 1953 ;Doolan et d., 1962; 4 October 1969 Creatinine Clearance in Renal Disease-Kim et al Tobias et al, 1962;Berlyne et al, 1964;Vere and Walduck, 1964) have reported that the differences between clearance of endogenous creatinine and clearance of inulin may be very small in some patients but in others may approach 50 to 100%. The data from our studies also emphasized this pronounced individual variability.…”