The effect of flurbiprofen, a nonsteroidal antiinflammatory agent, on ultraviolet B-induced erythema was studied in normal volunteers. The effect of various concentrations as well as the effect of multiple applications were evaluated at 4, 8, and 24 hours after irradiation with three MEDs of ultraviolet B. Repeated applications of flurbiprofen during the four- and eight-hour periods following ultraviolet B exposure did not increase the blanching response obtained following a single treatment. A concentration dependent effect of flurbiprofen on blanching was observed with suppression of erythema increasing with increasing concentration of flurbiprofen up to 3%. Further increase in concentration up to 5% offered no added advantage. Significant differences in blanching were also observed at different postirradiation time periods. No cutaneous or systemic complications were reported during the entire study.
Die Einführung des Radiojods in die Medizin durch Hamilton (17) sowie Hertz, Roberts und Evans (18) hat neue Möglichkeiten einer Untersuchung der Schilddrüse erschlossen. Das Radioisotop wird vom Schilddrüsengewebe ebenso wie das inaktive Element J127 in die Schilddrüsenhormone, das Thyroxin (Tetrajodthyronin) und das Trijodthyronin (16), eingebaut und so selektiv gespeichert. Die Aufnahme des Radiojods in das Organ sowie seine Ausschüttung als Hormonjod in cias Blut lassen sich mit geeigneten, besonders empfindlichen Zähirohren, den Szintillationszählern, quantitativ bestimmen und bilden die Grundlage einer subtilen Funktionsdiagnostik. Die hohe bevorzugte Radiojodspeicherung in der Drüse gibt aber auch die Möglichkeit, durch Abtastung der Aktivitätsverteilung Größe, Form und Lage der Schilddrüse zu bestimmen und ermöglicht so eine auch praktisch wichtige Lokalisationsdiagnostik.
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