Die Glykoside der Wurzeln von Asclepias swynnertonii S. Moore. Glykoside und Aglykone,303. Mitteilung

Jaggi, K.; Kaufmann, Heinz; Stöcklin, W.; Reichstein, T.

doi:10.1002/hlca.19670500831

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…PIFAB-MS spectra of C-I aglycone, exhibited a quasi molecular ion at m/z 391 [M+H] + gave the molecular ion of the aglycone in accordance with the molecular formula C 23 H 35 O 5 of trihydroxy substitution pattern for 3, 14, 19-trihydroxycard-20(22)-enolide. This aglycone was previously described as Coroglaucigenin and Carpogenol (Shoeba et al, 2004;Noor et al, 1993;Jolad et al, 1986;Dhawan & Singh, 1976;Abisch & Reichstein, 1962;Jäggi et al, 1967;Golab et al, 1960). …”

Section: Resultsmentioning

confidence: 94%

Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

Moustafa

Khodair

Saleh

2009

Pharmaceutical Biology

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Section: Resultsmentioning

confidence: 94%

Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

Moustafa

Khodair

Saleh

2009

Pharmaceutical Biology

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confidence: 99%

“…firmed from its spectral data, and sarcostin (5) was authenticated as the steroidal portion of both glycosides. The sugar portion of both glycosides was assumed to be on C-3 by analogy to other molecules of this type (5,6). Tic of the sugars from amplexoside B (2) on silica gel and cellulose sheets with three separate solvent systems (7) indicated three sugars, two of which corresponded to authentic cymarose and digitoxose while the third was not identified.…”

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confidence: 99%

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Cell Growth Inhibitory Glycosides from Asclepias amplexicaulis

Piatak¹,

Patel²,

Totten³

et al. 1985

J. Nat. Prod.

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Our prior study (1) of the roots from Asclepias amplexicaulis Sm (Asclepiadaceae) resulted in the isolation and identification of amplexoside A (1), which had shown cell growth inhibitory activity against the NCI KB cell line from a human nasopharnyx carcinoma (2) . In this report, we wish to present tentative structures for two additional glycosides from this plant, namely, amplexoside B (2) and amplexoside C (3) , which were found to have KB cell line ED50 values (2) of 3.9 and 0.14, re-

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Die Pregnanderivate der Samen von Dregea abyssinica (HOCHST.) K. Schum. (Asclepiadaceae). I. Isolierungen Glykoside und Aglykone, 304. Mitteilung

Bhatnagar

Kaufmann

Stöcklin

et al. 1968

Helvetica Chimica Acta

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Summary. The seeds of Dregea abyssinica (HOCHST.) K. SCHUM. are very rich in glycosides.These consist of a complicated mixture of ester glycosides, cardenolides are absent. All these glycosides are derived from only the two known pregnane derivatives drevogenin P and drevogenin D. I n the glycosides the latter are esterified with different acids (acetic, isovaleric, cr-hydroxyisovaleric and tiglic acid) and glycosidically linked to different 2-deoxy-sugars which in part carry 3-O-methyl-6-deoxy-~-allose and terminal D-glucose. After mild acidic hydrolysis 5 crystalline sugars and 6 crystalline aglycones could be isolated. The sugars were identified as D-Cymarose, asclepohiose, pachybiose, drebyssobiose and ((sugar T )) (formerly found in Dregea volubilis) .The following aglycones were obtained: drevogenin A, drevogenin B, and four new compounds called drehyssogenin F, G, J and K. The latter was a mixture of two components (K1 and K2). From the original mixture four genuine glycosides could be isolated (the drebyssosides 1, 2, 3 and 4). Of these the drebyssosides 1 and 3 were obtained crystalline, drebyssoside 2 in amorphous but pure form and drebyssoside 4 as a mixture of mainly two closely related components. The probable structures of the new substances (drebyssobiose, sugar T, the four drebyssogenins and the four drehyssosides) are reported in the following publication.

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Die Glykoside der Wurzeln von Asclepias swynnertonii S. Moore. Glykoside und Aglykone,303. Mitteilung

Cited by 10 publications

References 43 publications

Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

Structural elucidation and evaluation of toxicity and antitumor activity of cardiac glycosides isolated fromLeptadenia pyrotechnica

Cell Growth Inhibitory Glycosides from Asclepias amplexicaulis

Die Pregnanderivate der Samen von Dregea abyssinica (HOCHST.) K. Schum. (Asclepiadaceae). I. Isolierungen Glykoside und Aglykone, 304. Mitteilung

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