Die herzaktiven Substanzen der Meerzwiebel. Scillaren A

Stoll, A.; Suter, E.; Kreis, W.; Bussemaker, B. B.; Hofmann, A.

doi:10.1002/hlca.19330160198

Cited by 79 publications

(14 citation statements)

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“…Bufadienolides are a group of polyhydroxy C-24 steroids and their glycosides. The first described bufadienolide was scillaren A, identified in Egyptian squill ( Scilla maritima ) (Stoll et al 1933 ). The term “bufadienolides” originates from the genus Bufo —toads, which venom (a skin secretion) contains these compounds.…”

Section: Introductionmentioning

confidence: 99%

Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use

Kołodziejczyk-Czepas

Stochmal

2017

Phytochem Rev

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Toad venom is regarded as the main source of bufadienolides; however, synthesis of these substances takes also place in a variety of other animal and plant organisms, including ethnomedicinal plants of the Kalanchoe genus. Chemically, bufadienolides are a group of polyhydroxy C-24 steroids and their glycosides, containing a six-membered lactone (α-pyrone) ring at the C-17β position. From the pharmacological point of view, bufadienolides might be a promising group of steroid hormones with cardioactive properties and anticancer activity. Most of the literature concerns bufadienolides of animal origin; however, the medicinal use of these compounds remains limited by their narrow therapeutic index and the risk of development of cardiotoxic effects. On the other hand, plants such as Kalanchoe are also a source of bufadienolides. Kalanchoe pinnata (life plant, air plant, cathedral bells), Kalanchoe daigremontiana (mother of thousands) and other Kalanchoe species are valuable herbs in traditional medicine of Asia and Africa. The present review focuses on the available data on chemical structures of 31 compounds, biological properties and prospects for therapeutic use of bufadienolides from Kalanchoe species. Furthermore, it presents some new investigational trends in research on curative uses of these substances.

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Section: Introductionmentioning

confidence: 99%

Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use

Kołodziejczyk-Czepas

Stochmal

2017

Phytochem Rev

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“…Promising results were reported for bufadienolides from sea squill [2][3][4]. In the 1930s, Stoll and coworkers began with detailed investigations into Urginea maritima (L.) Baker; a botanical synonym of D. maritima, resulting in the isolation and structural elucidation of the first cardiac glycosides [5,6]. The cardioactive substances in sea squill were found to be similar to those of the toad genus Bufo and were consequently named bufadienolides.…”

Section: Introductionmentioning

confidence: 97%

Simultaneous determination of bufadienolides and phenolic compounds in sea squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages

Knittel

Stintzing

2014

Anal Bioanal Chem

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Mediterranean sea squill (Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MS(n) method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set.

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“…The principal bufadienolides reported [1,2] from Urginea indica, Indian squill, are proscillaridin A and scillaren A which are also the main glycosides of European squill, Urginea maritima BAKER [3]. Investigations on comparative potencies of European and Indian squill [4] have revealed no marked difference between the two species.…”

Section: Introductionmentioning

confidence: 97%

Quantitation of Principal Bufadienolides in Different Cytotypes of Urginea indica

Jha¹,

Sen²

1983

Planta Med

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Roots of URGINEA INDICA K UNTH, (Liliaceae) Indian squill, contain high amounts of proscillardin A and scillaren A. The range of variation in proscillaridin A and scillaren A contents in bulbs is 0.004-0.26% in diploids, 0.04-0.07% in triploids and 0.02-0.45% in tetraploids. The relative proportion of proscillaridin A and scillaren A also varies in different cytotypes. A tetraploid cytotype, representing a high yielding strain which can be exploited commercially for better yield of cardiac glycosides, has been obtained from Pune.

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Die herzaktiven Substanzen der Meerzwiebel. Scillaren A

Cited by 79 publications

References 10 publications

Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use

Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use

Simultaneous determination of bufadienolides and phenolic compounds in sea squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages

Quantitation of Principal Bufadienolides in Different Cytotypes of Urginea indica

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