Die Porphyrinproduktion des Propionibacterium acnes bei Acne und Seborrhoe

Abstract

The porphyrin productions of P a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, With respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. When separated by TLC the acne material showed a more intense coproporphyrin band.

In vivo Porphyrin Production by P. acnes in Untreated Acne Patients and its Modulation by Acne Treatment

“…HPLC analysis of acne extractions revealed a qualitatively uniform porphyrin profile, with coproporphyrin III as the major porphyrin fraction, whereas coproporphyrin I was present in low concentrations, and protoporphyrin hardly at all. This result matches the porphyrin formation of previously published in vivo (12,21,22) and in vitro studies (23)(24)(25).…”

“…The considerable inter-individual variations in the porphyrin concentration observed in the present study have also been seen in previous investigations (21,23,24). Similar porphyrin patterns in comedones and inflamtnatory acne lesions implicate that inflammation is not caused by modulation of the porphyrin profile.…”

Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations

“…Molecules secreted by P. acnes , such as proteases, lipases, hemolysins, and porphyrins, can degrade host tissue and have been suggested as causal factors in acne ( 16 – 20 ). Porphyrins can generate reactive oxygen species and induce inflammation in keratinocytes ( 21 – 23 ). Previous studies have shown correlations between acne severity and the concentrations of bacterium-derived porphyrins in the hair follicle.…”

Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III

“… 4,5 , 8 The release of cytokines after contact with P. acnes may be important for the attraction and migration of effector cells (lymphocytes, macrophages, neutrophils) into the epithelial tissue. One possible mechanism for keratinocyte damage leading to cytokine release may be the production and secretion of porphyrins by P. acnes 9 . We analysed by high‐performance liquid chromatography (HPLC) the in vivo porphyrin pattern produced by P. acnes which had been obtained from inflammatory acne lesions.…”