Die Wirkung von Phenylbutazon auf das Pfotenödem der Ratte nach oraler Applikation

Nonsteroid Anti-Inflammatory Agents

“…Since the last three compounds are unquestionably active anti-inflammatory and antirheu matic agents, the phlogistic materials listed above may be considered to be unsuitable for screening for such compounds (129,245).…”

“…Phlogistic agents that have been described as producing edema which can be inhibited by moderate doses of known anti-inflammatory agents in clude mustard powder (198,245), kaolin (54, 95,129,213), and a finely powdered glass known as "aerosil" (214). Several laboratories have re cently used carrageenan, a polysaccharide derived from Chondrus, Irish sea moss.…”

“…Dextran, egg white, and formalin have been widely used to induce edema in the feet of rats; edema produced by these agents can be inhibited by anti-inflammatory stetoids, by antihistaminic or anti serotonin com pounds (69,87,113,245), or by a variety of other agents which are not specifically anti-inflammatory (239), but not by nontoxic doses of phenylbu tazone, indomethacin, or flufenamic acid (129,197,239,245). Since the last three compounds are unquestionably active anti-inflammatory and antirheu matic agents, the phlogistic materials listed above may be considered to be unsuitable for screening for such compounds (129,245).…”

“…There are some pharmacological differences, as oxy phenbutazone is said to have slight anti serotonin activity (70) and to be inactive in the ultraviolet erythema test for anti-inflammatory activity, though more active than phenylbutazone on the granuloma pouch. Statisti cally controlled studies, with responses related to log dose, are lacking in much of the published work on phenylbutazone and related compounds, al though they can be as easily obtained with these compouri ds, employing doses below the grossly toxic range (129,240,245,250), as with other classes of pharmacologically active agents. A wide variety of toxic reac tions to phenylbutazone have been observed, as could be expected with an active drug so widely used; these have recently been reviewed (132).…”