Nonsteroid Anti-Inflammatory Agents

Winter, Charles A.

doi:10.1146/annurev.pa.06.040166.001105

Cited by 27 publications

(3 citation statements)

References 58 publications

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“…The release of endogenous corticosteroids by curcumin may also help indirectly in stabilizing lysosomal membrane, because glucocorticoids are known to have stabilizing effect on the lysosomal enzymes as evidenced by several experiments. [78], [79] Inflammation caused a significant increase in adrenal ascorbic acid and cholesterol level. A dose of 200 mg/kg of curcumin significantly decreased the adrenal ascorbic acid without affecting the cholesterol level.…”

Section: Release Of Hormonesmentioning

confidence: 99%

Curcumin: A natural antiinflammatory agent

et al. 2005

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The rhizome of turmeric is widely used in indigenous medicine. [1] A paste made from powdered rhizome of Curcuma longa Linn., mixed with slaked lime applied locally, is an ancient household remedy for sprains, muscular pain and inflamed joints. It is also applied in poultices to relieve pain and inflammation. [2] The volatile oil and curcumin obtained from C. longa exhibit potent antiinflammatory effect. [3] Curcumin is yellow coloured phenolic pigment, [4] obtained from powdered rhizome of C. longa Linn. (Family-Zingiberaceae). It is the major constituent of the oleoresin of turmeric. In the crude extract of rhizomes of C. longa about 70-76% curcumin is present along with about 16% demethoxycurcumin and 8% bisdemethoxycurcumin. It is extensively used for imparting colour and flavour to the food and in the traditional Indian medicine, turmeric powder is used to treat a wide variety of diseases. Extensive scientific research on curcumin have demonstrated a wide spectrum of therapeutic effects such as antiinflammatory, [5] antibacterial, [6] antiviral, [7] antifungal, [8] antitumor, [9] antispasmodic [10] and hepatoprotective. [11] Recently, its potential utility in autoimmune deficiency syndrome (AIDS) has been demonstrated. [12]-[14] In this review, the findings on curcumin's antiinflammatory activity and its mechanisms are presented. Preclinical studies Curcumin and antiinflammatory activity Arora et al reported antiinflammatory activity in different fractions of the petroleum ether extract of C. longa. [5] The total

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Section: Release Of Hormonesmentioning

confidence: 99%

Curcumin: A natural antiinflammatory agent

et al. 2005

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“…The number of drugs, exhibiting an anti-inflammatory activity in the classical tests in experimental animals has been constantly growing (29). The ultimate criterion is, therefore, a controlled clinical trial.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of 6-Azauridine

Trnavskỳ¹,

Lapárová²

1967

Pharmacology

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“…A number of reviews cover the subject of anti-in flammatory agents. These include general reviews (48)(49)(50)(51)(52) and discussions of steroid hormones (53), histamine antagonists (54), salicylates (55), anti rheumatic drugs (56), and the effect of drugs on mast cells (57». cellular events in animals (84,85). The cell types are easily identified and quantified and are viable for physiological study.…”

Section: Introductionmentioning

confidence: 99%