Dielectric/charge density modulated junctionless FET based label-free biosensor

Priyadarshani, Kumari Nibha; Singh, Sangeeta; Mohammed, Mustafa K. A.

doi:10.1016/j.inoche.2022.110350

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…Therefore, the accurate detection and monitoring of dopamine levels are of utmost importance for managing various neurological and psychiatric conditions, and the development of high-performance dopamine sensors can significantly improve the diagnosis and treatment of dopamine-related disorders. Field-effect transistor (FET)-type chemical sensors have gained significant attention for rapid and accurate label-free detection with low power consumption and CMOS compatibility [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

High-Performance FET-Based Dopamine-Sensitive Biosensor Platform Based on SOI Substrate

Hyun

Cho

2023

Biosensors

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Dopamine is a catecholamine neurotransmitter that plays a significant role in the human central nervous system, even at extremely low concentrations. Several studies have focused on rapid and accurate detection of dopamine levels using field-effect transistor (FET)-based sensors. However, conventional approaches have poor dopamine sensitivity with values <11 mV/log [DA]. Hence, it is necessary to increase the sensitivity of FET-based dopamine sensors. In the present study, we proposed a high-performance dopamine-sensitive biosensor platform based on dual-gate FET on a silicon-on-insulator substrate. This proposed biosensor overcame the limitations of conventional approaches. The biosensor platform consisted of a dual-gate FET transducer unit and a dopamine-sensitive extended gate sensing unit. The capacitive coupling between the top- and bottom-gate of the transducer unit allowed for self-amplification of the dopamine sensitivity, resulting in an increased sensitivity of 373.98 mV/log[DA] from concentrations 10 fM to 1 μM. Therefore, the proposed FET-based dopamine sensor is expected to be widely applied as a highly sensitive and reliable biosensor platform, enabling fast and accurate detection of dopamine levels in various applications such as medical diagnosis and drug development.

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Section: Introductionmentioning

confidence: 99%

High-Performance FET-Based Dopamine-Sensitive Biosensor Platform Based on SOI Substrate

Hyun

Cho

2023

Biosensors

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“…The bene ts of the ferroelectric layer and junctionless structures, as well as the creation of cavities in the oxide regions for inserting the biomolecules, is what distinguishes our work. A dielectric-modulated FET can be used to implement this form of a biosensor [12]. Even though simulation and modeling of dielectric modulated FETs have been documented in many publications, they are typically used for sensing biomolecules in dry environments [12]- [14].…”

Section: Introductionmentioning

confidence: 99%

“…A dielectric-modulated FET can be used to implement this form of a biosensor [12]. Even though simulation and modeling of dielectric modulated FETs have been documented in many publications, they are typically used for sensing biomolecules in dry environments [12]- [14]. Therefore, a Gate Engineered Ferroelectric Junctionless BioFET (GE-FJ-BioFET) capable of detecting diverse biomolecules such as enzymes, proteins, and DNAs [15] is described in this study.…”

Section: Introductionmentioning

confidence: 99%

Gate Engineered Ferroelectric Junctionless BioFET for Label-Free Detection of Biomolecules

Yadav

Rewari

Pandey

2023

Preprint

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A Gate Engineered Ferroelectric Junctionless BioFET is proposed and investigated for label-free detection of various biomolecules. A nanocavity is created by etching a part of the gate oxide material on the top and bottom of the device, which allows biomolecules to get immobilized. The immobilization of biomolecules in the cavity causes changes in electrostatic characteristics such as surface potential, input and output characteristics, transconductance, output conductance, gate capacitance, and cut-off frequency used as sensing metrics. The biosensor is also examined at different biomolecule concentrations, such as -1e12, 0, and 1e12. The transistor's sensitivity is then understood by looking at the fluctuation in threshold voltage, subthreshold swing, and switching ratio. Ferroelectric Junctionless BioFET and Gate Engineered Ferroelectric Junctionless BioFET performances have been compared. It has been found that the Gate Engineered Ferroelectric Junctionless BioFET shows the maximum improvement for protein (1202.4%, 111%, and 565%) and DNA (787.5%, 117.3%, and 600%). For ultrasensitive bio-sensing applications, the Gate Engineered Ferroelectric Junctionless BioFET is shown to be suitable.

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Comprehensive review on charge plasma based junction less TFET biosensor

Jaya,

Lorenzo

2024

Microsyst Technol

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Dielectric/charge density modulated junctionless FET based label-free biosensor

Cited by 7 publications

References 37 publications

High-Performance FET-Based Dopamine-Sensitive Biosensor Platform Based on SOI Substrate

High-Performance FET-Based Dopamine-Sensitive Biosensor Platform Based on SOI Substrate

Gate Engineered Ferroelectric Junctionless BioFET for Label-Free Detection of Biomolecules

Comprehensive review on charge plasma based junction less TFET biosensor

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