Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection

Miled, Mohamed Amine

doi:10.1109/tbcas.2012.2185844

Cited by 65 publications

(40 citation statements)

References 33 publications

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“…Indeed, when the electrodes are closer, the capacitive sensor is more affected by the liquid change between the electrode plates and not by the medium change. This is because the electrode shape is planar and the liquid is passing on the top of plates [18]. Thus, when the cells are smaller than 1 lm, a smaller electrode space offers a better accuracy.…”

Section: Capacitive Sensor Experimental Resultsmentioning

confidence: 99%

Low-voltage lab-on-chip for micro and nanoparticles manipulation and detection: experimental results

Miled

Massicotte

2012

Analog Integr Circ Sig Process

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In this paper, a low voltage fully integrated Laboratory-on-Chip (LoC) for dielectrophoretic manipulation and capacitive sensing of nano and micro particles is presented. The proposed system is intended to design an implantable LoC. The lowest static power consumption of the implemented Integrated circuit is 650 lA with a voltage supply of -1.10 and ?1.8 V. Three different sizes of carboxyl-modified polystyrene particles (diameters of 0.22, 0.97 and 2.04 lm) where tested experimentally with three different electrode architectures to achieve dielectrophoretic mixing and separation. U-shaped, L-shaped and octagonal electrodes are used to perform the separation and mixing operations. The biosensing part is designed with a charge based capacitive sensor with an integrated sigmadelta modulator at its output stage. It was tested experimentally with algae and ethanol. The chip size is 1.2 by 1.2 mm and it is connected to a 15 9 30 cm microfluidic design. An efficient particle manipulation was achieved by applying a voltage of 1.7 V peak to peak in the microchannel with 90 and 180°dephased signals.

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Section: Capacitive Sensor Experimental Resultsmentioning

confidence: 99%

Low-voltage lab-on-chip for micro and nanoparticles manipulation and detection: experimental results

Miled

Massicotte

2012

Analog Integr Circ Sig Process

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“…[18] Further on-chip micro control of the DEP could render the integration process more flexible. [37] Moreover, CNT and sensor surface modification techniques to enhance sensor selectivity can be applied after integration, similar to those reported for single CNT devices or CNT carpet-based devices. [1] Experimental Section…”

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confidence: 90%

Dielectrophoresis‐Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem

Seichepine¹,

Rothe

Dudina

et al. 2017

Advanced Materials

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Carbon-nanotube (CNT)-based sensors offer the potential to detect single-molecule events and picomolar analyte concentrations. An important step toward applications of such nanosensors is their integration in large arrays. The availability of large arrays would enable multiplexed and parallel sensing, and the simultaneously obtained sensor signals would facilitate statistical analysis. A reliable method to fabricate an array of 1024 CNT-based sensors on a fully processed complementary-metal-oxide-semiconductor microsystem is presented. A high-yield process for the deposition of CNTs from a suspension by means of liquid-coupled floating-electrode dielectrophoresis (DEP), which yielded 80% of the sensor devices featuring between one and five CNTs, is developed. The mechanism of floating-electrode DEP on full arrays and individual devices to understand its self-limiting behavior is studied. The resistance distributions across the array of CNT devices with respect to different DEP parameters are characterized. The CNT devices are then operated as liquid-gated CNT field-effect-transistors (LG-CNTFET) in liquid environment. Current dependency to the gate voltage of up to two orders of magnitude is recorded. Finally, the sensors are validated by studying the pH dependency of the LG-CNTFET conductance and it is demonstrated that 73% of the CNT sensors of a given microsystem show a resistance decrease upon increasing the pH value.The potential of carbon nanotubes (CNTs) as electronic sensors in liquid environments has been extensively demonstrated. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts electronic environment and the nanotube's high surface/volume ratio render them particularly suited for sensing applications in liquid phases. Furthermore, through functionalization of the CNTs, a specificity for numerous analytes can be achieved. [1][2][3][4][5] Highly sensitive CNT nanosensors have been demonstrated in liquid-gate CNT field-effecttransistor (LG-CNTFET) configurations, where the carrier density of the CNT gate was controlled via a potential applied to the surrounding electrolyte.[6] By using LG-CNTFET sensors consisting of only a single or a small number of individual CNTs as sensing material, only few molecules are required to generate detectable signals. In the case of DNA hybridization, even the detection of a single molecule is possible. [7,8] Despite their application potential in point-of-care diagnosis and label-free sensing, the widespread use of CNT nanosensor technologies is still hampered by technological hurdles. First of all, a route to fabricating large numbers of devices with reproducible characteristics has to be developed. Additionally, the high sensitivity of CNT sensors entails the presence of baseline fluctuations due to unspecific and random adsorption events, which are likely to create detection errors.[9] Finally, the limited adsorption area of single-CNT nanosensors leads to slow response times for low concentrations.[10]A possibility to overcome some o...

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“…Diverse range of uses is the dielectrophoresis applications where CMOS-based lab-on a-chip is utilized to recognize microbes, bacteria and cancer cells [14]. Manaresi et al [25,26] proposed a CMOS lab-on-a-chip for cell control and identification.…”

Section: Dielectrophoresis (Dep)mentioning

confidence: 99%

“…Particles are detected by photodiodes, embedded in the substrate that measure signal variations from uniform light impinging on the chip surface. Recently, Miled et al presented a CMOS-based lab-on-chip system for dielectrophoresis-based cell manipulation and detection [27]. The lab-on-a-chip based on CMOS technology is fabricated utilizing a CMOS full-custom chip and a microfluidic chamber.…”

Section: Dielectrophoresis (Dep)mentioning

confidence: 99%

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CMOS Circuits and Systems for Lab‐on‐a‐Chip Applications

Ghallab¹,

Ismail²

2016

Lab-on-a-Chip Fabrication and Application

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Complementary metal oxide semiconductor (CMOS) technology allows the functional integration of sensors, signal conditioning, processing circuits and development of fully electronic integrated lab-on-a-chip. On the other hand, lab-on-a-chip is a technology which changed the traditional way by which biological samples are inspected and tested in laboratories. A lab-on-a-chip consists of four main parts: sensing, actuation, readout circuit and microfluidic chamber. Lab-on-a-chip gives the promise of many advantages including better and improved performance, reliability, portability and cost reduction. This chapter reviews the currently used lab-on-a-chips based on CMOS technology. Also, this chapter presents and discusses the features of the existing CMOS based lab-on-a-chips and their applications at the cell level.

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Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection

Cited by 65 publications

References 33 publications

Low-voltage lab-on-chip for micro and nanoparticles manipulation and detection: experimental results

Low-voltage lab-on-chip for micro and nanoparticles manipulation and detection: experimental results

Dielectrophoresis‐Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem

CMOS Circuits and Systems for Lab‐on‐a‐Chip Applications

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