Diet and Alzheimer's dementia – Nutritional approach to modulate inflammation

Szczechowiak, Katarzyna; Diniz, Breno S.; Leszek, Jerzy

doi:10.1016/j.pbb.2019.172743

Cited by 83 publications

(80 citation statements)

References 105 publications

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“…The mechanism of favorable actions of caffeine on AD may be connected with the reduction of neuroinflammation [5,186]. AD and other neurodegenerative diseases are associated with an increased level of inflammation and oxidative stress parameters.…”

Section: Discussionmentioning

confidence: 99%

“…It is believed, especially taking into account very limited therapeutic options, that dietary interventions or nutraceuticals may be promising in the prophylaxis and treatment of cognitive impairment of ageing, including AD [2][3][4][5][6][7]. The effects of dietary components are usually evaluated based on dietary questionnaires, and the results of those studies, as well as the results of their meta-analyses are often not conclusive.…”

Section: Introductionmentioning

confidence: 99%

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Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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Alzheimer’s disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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“… 71 The inflammatory component of AD has been treated by supplementation with fatty acids, vitamins, flavonoids, polyphenols, probiotics, and dietary advanced glycation end products. 72 Ketogenic diets, which are protective in other neurological disorders, also seem to have great potential in the prevention and treatment of the disease. 73 In humans, few clinical trials have been carried out using ketogenic diets; instead, ketogenic agents have been used.…”

Section: Physical Exercise and Multimodal Interventions For The Treatmentioning

confidence: 99%

Physical exercise in the prevention and treatment of Alzheimer's disease

Rosa

Olaso‐González

Arc-Chagnaud

et al. 2020

Journal of Sport and Health Science

325

170

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“…Extensive scientific researches indicate that gut microbiota play a crucial role in AD neurodegenerative mechanism. Neuroactive compounds like dopamine, melatonin, serotonin, and γ-aminobutyric acid (GABA) are produced by gut microbiota ( Szczechowiak et al, 2019 ). However, certain gut bacteria synthesize detrimental lipopolysaccharides and amyloid peptides, inducing inflammation in AD patients.…”

Section: Health-boosting Spectrum Of Probioticsmentioning

confidence: 99%

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

2020

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Probiotics are considered as the twenty-first century panpharmacon due to their competent remedial power to cure from gastrointestinal dysbiosis, systematic metabolic diseases, and genetic impairments up to complicated neurodegenerative disorders. They paved the way for an innovative managing of various severe diseases through palatable food products. The probiotics’ role as a “bio-therapy” increased their significance in food and medicine due to many competitive advantages over traditional treatment therapies. Their prophylactic and therapeutic potential has been assessed through hundreds of preclinical and clinical studies. In addition, the food industry employs probiotics as functional and nutraceutical ingredients to enhance the added value of food product in terms of increased health benefits. However, regardless of promising health-boosting effects, the probiotics’ efficacy still needs an in-depth understanding of systematic mechanisms and factors supporting the healthy actions.

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Diet and Alzheimer's dementia – Nutritional approach to modulate inflammation

Cited by 83 publications

References 105 publications

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Physical exercise in the prevention and treatment of Alzheimer's disease

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

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