Diet compounds, glycemic index and obesity-related cardiac effects

Diniz, Yeda S.; Burneiko, Regina Miranda; Seiva, Fábio Rodrigues Ferreira; Aranha, Flávia Queiroga; Galhardi, Cristiano Machado; Filho, José Luiz V. B. Novelli; Mani, Fernanda; Novelli, Ethel L. B.

doi:10.1016/j.ijcard.2006.12.025

Cited by 32 publications

(37 citation statements)

References 36 publications

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“…Previous studies in our laboratory demonstrated that addition of sucrose to drinking water enhanced the energy intake in spite of the lower food consumption [11]. Therefore, a lower energy intake from chow was compensated by additional calories from the aqueous sucrose solutions.…”

Section: Discussionmentioning

confidence: 97%

“…Blood was taken from a tail vein and glucose concentrations were determined by an automatic glucose analyser (Boehringer Mannheim, Eli Lilly Ltda, São Paulo, Brazil). The glycemic response was calculated from the area under the glucose-response curve above the fasting level [11], as a mean to estimate release insulin in response to glucose [18]. After the OGTT, the animals were anaesthetized (0.1 ml ip of 1% sodium barbiturate) for measurement of the body length [17], and were sacrificed by decapitation.…”

Section: Methodsmentioning

confidence: 99%

“…An increasingly preference for refined foods and diet containing high levels of sucrose has resulted in a drastic increase in the incidence of obesity. Dietary sucrose is an important modulator of the obesity-related diseases [11], but whether dietary NAC can reverse these adverse effects merits to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects

Souza

Ebaid

Seiva

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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This study was designed to determine whether N-acetylcysteine (NAC, C5H9–NO3S), a compound from Allium species may be used as a complementary therapeutic agent, to inhibit high-sucrose induced-obesity and its effects on glucose tolerance, in vivo low-density lipoprotein (LDL)-oxidation and serum oxidative stress in rats. Initially, 24 male Wistar rats were divided into two groups: controls receiving standard chow (C, n = 6) and those receiving high-sucrose diet (HS, n = 18). After 22 days, (HS) group was divided into three groups (n = 6/group); (HS-HS) continued to eat high-sucrose diet and water; (HS-N) continued to eat high-sucrose diet and received 2 mg l−1-NAC in its drinking water; (HS-CN) changing high-sucrose to standard chow and receiving 2 mg l1-NAC in its drinking water. After 22 days of the HS-group division (44 days of experimental period) body weight, body mass index and surface area were enhanced in HS-HS rats (P < .001). HS-HS rats had glucose intolerance, increased serum triacylglycerol (TG), very low-density lipoprotein (VLDL), oxidized-LDL (ox-LDL) and lipid-hydroperoxide (LH) than the others (P < .01). NAC in HS-N and HS-CN rats reduced the obesity markers, feed efficiency, LH and ox-LDL, as well normalized glucose response, TG and VLDL (P < .01) in these groups compared with HS-HS. Total antioxidant substances, GSH/GSSG ratio and glutathione-reductase, were higher in HS-N than in HS-HS (P < .01). In conclusion, NAC improved high-sucrose diet-induced obesity and its effects on glucose tolerance, lipid profile, in vivo LDL-oxidation and serum oxidative stress, enhancing antioxidant defences. The application of this agent may be feasible and beneficial for high-sucrose diet-induced obesity, which certainly would bring new insights on obesity-related adverse effects control.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

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N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects

Souza

Ebaid

Seiva

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…It is an independent risk factor for cardiovascular disease with the high levels of circulating free fatty acids increasing the supply of fatty acids to the cardiomyocyte for fatty acid oxidation [2][3][4][5][6][7][8][9]. This increases the rate of fatty acid oxidation which suppresses glucose oxidation via the inhibition of pyruvate dehydrogenase (PDH).…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity

Maarman

Marais

Lochner

et al. 2012

Cardiovasc Drugs Ther

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“…Animal models are useful for increasing the understanding of the effects of diet and the development of obesity related abnormalities, particularly on cardiac tissue [15,18]. Therefore, we used a rat model to study the effects of olive oil and its phenolic compounds on an unresolved issue in the field of obesity and health that is the control of obesity-related cardiac metabolic alterations.…”

Section: Introductionmentioning

confidence: 99%

Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes

Ebaid

Seiva

Rocha

et al. 2010

Nutr J

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BackgroundOlive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes?MethodsMale Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive)standard-chow and olive-oil (3.0 g/kg.day); (C-Oleuropein)standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days.ResultsAfter 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO2) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO2, fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C.ConclusionsThe present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions.

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Diet compounds, glycemic index and obesity-related cardiac effects

Cited by 32 publications

References 36 publications

N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects

N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects

Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity

Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes

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