Diet-gene interaction: effects of polymorphisms in the ACE, AGT and BDKRB2 genes and the consumption of sodium, potassium, calcium, and magnesium on blood pressure of normotensive adult individuals

Giovanella, Janine; Wollinger, Luana Maria; Capra, Luisa; Dresch, Fabiane; Genro, Júlia Pasqualini; Contini, Verônica

doi:10.1007/s11010-020-03983-5

Cited by 9 publications

(7 citation statements)

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“…Thus, these results indicated significant interactions between genetic polymorphisms (rs699-AGT and rs1799722-BDKRB2) and micronutrient consumption (sodium, magnesium, and calcium) on BP variation. These findings could contribute to an understanding of the complex mechanisms involved in the regulation of BP, which probably include several gene-nutrition interactions [106] Many aspects of genetic testing are still limited, including the complexity of genenutrient interactions, the accuracy of genetic assessments, and the application of genetic knowledge; however, nutritional genomics could provide information on how diet and genotype interactions affect phenotype. Therefore, it is necessary for the healthcare professional to be trained in genetic counseling for the interpretation of data in order to identify the most appropriate nutritional approach, considering that individuals have different dietary needs and varied metabolism [107,108].…”

Section: Nutritional Genomicsmentioning

confidence: 98%

Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics

Riolo

Rosa

Simonetta

et al. 2022

IJMS

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Human nutrition is a relatively new science based on biochemistry and the effects of food constituents. Ancient medicine considered many foods as remedies for physical performance or the treatment of diseases and, since ancient times, especially Greek, Asian and pre-Christian cultures similarly thought that they had beneficial effects on health, while others believed some foods were capable of causing illness. Hippocrates described the food as a form of medicine and stated that a balanced diet could help individuals stay healthy. Understanding molecular nutrition, the interaction between nutrients and DNA, and obtaining specific biomarkers could help formulate a diet in which food is not only a food but also a drug. Therefore, this study aims to analyze the role of the Mediterranean diet and olive oil on cardiovascular risk and to identify their influence from the genetic and epigenetic point of view to understand their possible protective effects.

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Section: Nutritional Genomicsmentioning

confidence: 98%

Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics

Riolo

Rosa

Simonetta

et al. 2022

IJMS

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Section: Interactions Between Micronutrients and Genetic Variants On ...mentioning

confidence: 99%

“…The interaction between micronutrients and genetic variants on cardiometabolic traits was examined by five Brazilian studies (81)(82)(83)(84)(85). A cross-sectional study of 335 healthy young adults (81), observed a pronounced increase in systolic blood pressure (SBP) (P interaction = 0.016) among carriers of the "G" allele of Angiotensinogen (AGT) SNP rs699 with a higher plasma magnesium (209.3 mg). Similarly, among those with a high calcium intake (573.3 mg), carriers of the "T" allele of Bradykinin Receptor B2 (BDKRB2) SNP rs1799722 had significantly higher SBP (P interaction = 0.015) and diastolic BP (DBP) (P interaction = 0.014) than carriers of the "CC" genotype (81).…”

Section: Interactions Between Micronutrients and Genetic Variants On ...mentioning

confidence: 99%

“…Sodium is known to increase BP by reducing vasodilation (86), while dietary calcium is believed to stabilize intracellular calcium in smooth muscles, thereby reducing vasoconstriction and BP (87). Additionally, the "A" allele of AGT SNP rs699 is thought to be a risk factor for elevated SBP, possibly due to its association with a rise in plasma AGT levels (60,81), and the findings of the study discussed above (81) indicate that, the protective effect of the "G" allele might be lost in the presence of higher plasma magnesium.…”

Section: Interactions Between Micronutrients and Genetic Variants On ...mentioning

confidence: 99%

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Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

et al. 2023

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IntroductionThe prevalence of cardiometabolic diseases has increased in Latin American and the Caribbean populations (LACP). To identify gene-lifestyle interactions that modify the risk of cardiometabolic diseases in LACP, a systematic search using 11 search engines was conducted up to May 2022.MethodsEligible studies were observational and interventional studies in either English, Spanish, or Portuguese. A total of 26,171 publications were screened for title and abstract; of these, 101 potential studies were evaluated for eligibility, and 74 articles were included in this study following full-text screening and risk of bias assessment. The Appraisal tool for Cross-Sectional Studies (AXIS) and the Risk Of Bias In Non-Randomized Studies—of Interventions (ROBINS-I) assessment tool were used to assess the methodological quality and risk of bias of the included studies.ResultsWe identified 122 significant interactions between genetic and lifestyle factors on cardiometabolic traits and the vast majority of studies come from Brazil (29), Mexico (15) and Costa Rica (12) with FTO, APOE, and TCF7L2 being the most studied genes. The results of the gene-lifestyle interactions suggest effects which are population-, gender-, and ethnic-specific. Most of the gene-lifestyle interactions were conducted once, necessitating replication to reinforce these results.DiscussionThe findings of this review indicate that 27 out of 33 LACP have not conducted gene-lifestyle interaction studies and only five studies have been undertaken in low-socioeconomic settings. Most of the studies were cross-sectional, indicating a need for longitudinal/prospective studies. Future gene-lifestyle interaction studies will need to replicate primary research of already studied genetic variants to enable comparison, and to explore the interactions between genetic and other lifestyle factors such as those conditioned by socioeconomic factors and the built environment. The protocol has been registered on PROSPERO, number CRD42022308488.Systematic review registrationhttps://clinicaltrials.gov, identifier CRD420223 08488.

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“…Moreover, numerous population-based epidemiological studies have recognized that multiple dietary factors were associated with hypertension in recent years ( 5 ). For instance, extensive evidence has demonstrated that inappropriate consumption of calcium ( 6 , 7 ), phosphorus ( 8 , 9 ), sodium ( 7 , 10 , 11 ), potassium ( 11 , 12 ), magnesium ( 13 , 14 ) was intricately related with blood pressure. Additionally, various clinical and animal experimental studies have repeatedly revealed that dietary vitamin C and serum vitamin C were associated with blood pressure ( 15 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals

et al. 2022

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AimHypertension is among the most prevalent chronic diseases with diverse etiology, affecting over 1 billion people globally. In numerous studies, vitamin C inversely correlated with blood pressure and was suspected to have antihypertensive properties. Currently, there is conflicting evidence regarding the relationship between vitamin C and blood pressure, with most studies being conducted on hypertensive subjects. The principal objective of this project was to investigate the relationship between vitamin C and blood pressure in normotensive adult subjects.MethodsA total of 2,533 individuals aged 20 years and above were enrolled in the present study from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Outcome variables were systolic blood pressure (SBP) and diastolic blood pressure (DBP). Serum vitamin C was regarded as an independent variable. EmpowerStats software and R (version 3.4.3) were used to examine the association between vitamin C and SBP or DBP.ResultsVitamin C was reversely correlated with both SBP (β = −0.02, 95% CI: −0.03 to −0.00, p = 0.0306) and DBP (β = −0.02, 95% CI: −0.04 to −0.01, p = <0.0011) after adjusting all covariates. This reverse relationship may be affected by a number of factors, including a person’s gender, age, race, and ethnicity. A U-shaped association between vitamin C and SBP in females and an inverted one between vitamin C and DBP in males were detected, respectively. We further calculated the inflection points at 90.3 μmol/L for females and 40 μmol/L for males. It is somewhat surprising that a reverse U-shaped distribution between vitamin C and SBP and DBP in people over 50 was detected, and the point of inflection of vitamin C were all located at 40 μmol/L.ConclusionVitamin C was negatively correlated with both SBP and DBP in this cross-sectional analysis. However, a U-shaped relationship and an inverted one were also observed in certain people, which implied that, though vitamin C is considered a vital antioxidant, maintaining vitamin C at appropriate levels may be beneficial according to different populations.

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Diet-gene interaction: effects of polymorphisms in the ACE, AGT and BDKRB2 genes and the consumption of sodium, potassium, calcium, and magnesium on blood pressure of normotensive adult individuals

Cited by 9 publications

References 49 publications

Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics

Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics

Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals

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