Diet-induced oxalate nephropathy from excessive nut and seed consumption

Abstract

Oxalate is a metabolite consumed in nuts, beans and leaves, and excreted in urine. Oxalosis can cause nephropathy. We describe a rare case of a high-oxalate diet intended for irritable bowel syndrome (IBS) treatment causing oxalate nephropathy. A 59-year-old woman with a history of controlled hypertension presented with creatinine 1.8 mg/dL, increased from baseline 1.3 mg/dL. She denied recent illness, urinary stones, medication adjustments, herbal supplements and non-steroidal anti-inflammatory drugs use. Diet included six tablespoons of chia seeds and five handfuls of almonds daily to manage IBS symptoms. Her electrolytes, urinalysis and renal ultrasound were unremarkable. Her 24-hour urine output revealed increased oxalate and low citrate. Renal biopsy showed glomerulosclerosis, fibrosis and calcium oxalate deposition. She switched to a low-oxalate diet, with improvement in laboratory markers. An earlier dietary history could have raised concern for oxalosis prior to renal biopsy. Providers should be trained to identify at-risk patients and provide appropriate dietary counselling.

Renal hypoxia, vascular calcification and crystalline nephropathy

“…O Consumo de alimentos ricos em oxalato acabam por expor uma não intencional consequência da ingestão excessiva de amêndoas e sementes pela suspeição de possíveis benefícios para a saúde e melhoria dos sintomas da síndrome do intestino irritável (SII), destacando a estreita relação entre nutrição, o trato gastrointestinal e a saúde renal 41 .…”

Ketogenic diet and the risk of kidney stones

“…Do produktów mogących powodować powstawanie kamieni należą również orzechy. Zawarte w nich szczawiany spożywane w nadmiarze mogą prowadzić do odkładania się kamieni szczawianowo-wapniowych w kanalikach nerkowych [41].…”

A Combination of Xyloglucan, Pea Protein and Chia Seed Ameliorates Intestinal Barrier Integrity and Mucosa Functionality in a Rat Model of Constipation-Predominant Irritable Bowel Syndrome

“…Their solubility, strong water- and oil-holding capacities, and emulsifying properties make them good gelling agents to be used in foods and therapeutics alike. Indeed, Xyloglucan and Pea Protein (XP) have previously been reported to restore the intestinal barrier, thanks to their muco-mimetic properties [ 15 , 16 ], and to improve intestinal permeability in IBS-D patients [ 13 ]. Chia seeds (CS) are small dark seeds of the chia plant, which are rich in calcium, vitamin C, omega-3 and fiber.…”