DieTalgdrüse als Transporter für Vitamin E

Ekanayake‐Mudiyanselage, Swarna; Thiele, Jens J.

doi:10.1007/s00105-005-1090-7

Cited by 30 publications

(16 citation statements)

References 37 publications

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“…Reaching the skin surface, they penetrate into the skin like topically applied carotenoids. Such penetration characteristics were observed by Thiele et al [14,21] for the antioxidant substance vitamin E. A transport of the carotenoids onto the skin surface by the continuous renewal of the SC is improbable, because in this case the concentration profile of the carotenoids should have an inverse tendency -the highest concentration should be on the boundary between the SC and the living epidermis and the lowest concentration on the skin surface.…”

Section: Discussionmentioning

confidence: 79%

In vivoRaman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids

Lademann

Caspers²,

Pol³

et al. 2009

Laser Phys. Lett.

110

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Abstract:In the present study, the distribution of the carotenoids as a marker for the complete antioxidative potential in human skin was investigated before and after the topical application of carotenoids by in vivo Raman spectroscopy with an excitation wavelength of 785 nm. The carotenoid profile was assessed after a short term topical application in 4 healthy volunteers. In the untreated skin, the highest concentration of natural carotenoids was detected in different layers of the stratum corneum (SC) close to the skin surface. After topical application of carotenoids, an increase in the antioxidative potential in the skin could be observed. Topically applied carotenoids penetrate deep into the epidermis down to approximately 24 μm. This study supports the hypothesis that antioxidative substances are secreted via eccrine sweat glands and/or sebaceous glands to the skin surface. Subsequently they penetrate into the different layers of the SC.

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Section: Discussionmentioning

confidence: 79%

In vivoRaman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids

Lademann

Caspers²,

Pol³

et al. 2009

Laser Phys. Lett.

110

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“…The skin surface lipid (SSL) film, a mixture of sebum and keratinocyte membrane lipids, is the first barrier against environmental stress [134]. Among the ingredients of SSL, squalene, a key biosynthetic precursor of cholesterol secreted by SGs, and α-tocopherol (vitamin E) secreted together with lipids from sebaceous gland, provide collaboratively antioxidant protection to the skin surface [135][136][137]. In addition, the by-products, squalene peroxides, produce during squalene oxidation, are considered to be involved in inflammatory and immunologically determined skin diseases, such as acne, atopic and seborrheic dermatitis as well as in skin cancerogenesis [138].…”

Section: Sebaceous Glands and Skin Skin Detoxificationmentioning

confidence: 99%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

118

112

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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“…The presented explanation is confirmed by the fact that the concentration of carotenoids in the epidermis is higher in body sites with a high density of sweat glands (66), such as the palm, planta and the forehead, in comparison with other areas (36). The same effect had been observed previously for vitamin E (67).…”

Section: Accumulation Of Carotenoids In Human Skinmentioning

confidence: 99%

Carotenoids in human skin

Lademann

Meinke

Sterry

et al. 2011

Experimental Dermatology

104

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The interaction of free radicals with antioxidants is a topic of increasing interest in the development of prevention strategies against skin ageing. Carotenoids can serve as marker substances for the complete antioxidative network of human skin. Recently, it has become possible to measure the carotenoids noninvasively and online using resonance Raman spectroscopy. This method has been used in various studies to investigate the interaction of carotenoid antioxidants and free radicals in human skin. In this review, the results of the selected studies are summarized and compared. It could be demonstrated that the carotenoid concentration of the skin reflects the lifestyle of individuals. A high level of carotenoids can be achieved with a healthy diet rich, for instance, in fruit and vegetables. Stress factors such as illness, UV and IR radiation of the sun, and smoking and alcohol consumption reduce the concentration of the carotenoids in the skin. It could be demonstrated that premature skin ageing was less in people with a high level of antioxidants in their tissue. Consequently, the furrows and wrinkles were not so deep and dense as in the skin of individuals with a low antioxidant level. The measurements are highly suited for the development of anti-ageing strategies and can be efficiently used in the medical diagnostics and therapy control.

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DieTalgdrüse als Transporter für Vitamin E

Cited by 30 publications

References 37 publications

In vivoRaman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids

In vivoRaman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids

Beyond acne: Current aspects of sebaceous gland biology and function

Carotenoids in human skin

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