Dietary activators of Sirt1

Allard, Joanne; Perez, Evelyn; Zou, Sige; Cabo, Rafael de

doi:10.1016/j.mce.2008.10.018

Cited by 85 publications

(61 citation statements)

References 91 publications

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“…Resveratrol has been shown to increase lifespan and promote health span in model organisms ranging from yeast, worms, flies, and mice (Allard et al 2009;Pirola and Frojdo 2008). However, the prolongevity effect of resveratrol and its underlying mechanisms have been challenged by studies from several labs and remain controversial (Bass et al 2007b;Kaeberlein et al 2005).…”

Section: Discussionmentioning

confidence: 99%

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang

Wheeler

Alberico

et al. 2011

AGE

Self Cite

101

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Resveratrol, a polyphenolic compound, has been shown to extend lifespan in different organisms. Emerging evidence suggests that the prolongevity effect of resveratrol depends on dietary composition. However, the mechanisms underlying the interaction of resveratrol and dietary nutrients in modulating lifespan remain elusive. Here, we investigated the effect of resveratrol on lifespan of Drosophila melanogaster fed diets differing in the concentrations of sugar, yeast extract, and palmitic acid representing carbohydrate, protein, and fat, respectively. Resveratrol at up to 200 μM in diets did not affect lifespan of wild-type female flies fed a standard, restricted or high sugar-low protein diet, but extended lifespan of females fed a low sugar-high protein diet. Resveratrol at 400 μM extended lifespan of females fed a high-fat diet. Lifespan extension by resveratrol was associated with downregulation of genes in aging-related pathways, including antioxidant peroxiredoxins, insulin-like peptides involved in insulin-like signaling and several downstream genes in Jun-kinase signaling involved in oxidative stress response. Furthermore, resveratrol increased lifespan of superoxide dismutase 1 (sod1) knockdown mutant females fed a standard or high-fat diet. No lifespan extension by resveratrol was observed in wild-type and sod1 knockdown males under the culture conditions in this study. Our results suggest that the gender-specific prolongevity effect of resveratrol is influenced by dietary composition and resveratrol promotes the survival of flies by modulating genetic pathways that can reduce cellular damage. This study reveals the context-dependent effect of resveratrol on lifespan and suggests the importance of dietary nutrients in implementation of effective aging interventions using dietary supplements.

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Section: Discussionmentioning

confidence: 99%

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang

Wheeler

Alberico

et al. 2011

AGE

Self Cite

101

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“…Various studies have shown that SIRT1, an NAD + -dependent deacetylase, is a molecular target of resveratrol (27,34,35). We therefore tested whether administration of SRT1720, a small molecule activator of resveratrol, mimics the life-extending effect of resveratrol in nonresuscitated rats.…”

Section: R E S E a R C H A R T I C L E M O L M Ementioning

confidence: 99%

Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock

Ayub

Poulose

Raju

2015

Mol Med

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Resveratrol has been shown to potentiate mitochondrial function and extend longevity; however, there is no evidence to support whether resveratrol can improve survival or prolong life following hemorrhagic shock. We sought to determine whether (a) resveratrol can improve survival following hemorrhage and resuscitation and (b) prolong life in the absence of resuscitation. Using a hemorrhagic injury (HI) model in the rat, we describe for the first time that the naturally occurring small molecule, resveratrol, may be an effective adjunct to resuscitation fluid. In a series of three sets of experiments we show that resveratrol administration during resuscitation improves survival following HI (p < 0.05), resveratrol and its synthetic mimic SRT1720 can significantly prolong life in the absence of resuscitation fluid (<30 min versus up to 4 h; p < 0.05), and resveratrol as well as SRT1720 restores left ventricular function following HI. We also found significant changes in the expression level of mitochondria-related transcription factors Ppar-α and Tfam, as well as Pgc-1α in the left ventricular tissues of rats subjected to HI and treated with resveratrol. The results indicate that resveratrol is a strong candidate adjunct to resuscitation following severe hemorrhage.

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“…An increased expression of SIRT1 is capable of extending the life span of model organisms and it appears that the activity of Sir2 (a homolog of SIRT1) is required for the lifeextending benefits of caloric restriction in organisms such as yeast and flies (10). SIRT1 levels are regulated by microRNAs (miRNAs) that have emerged as significant metabolic regulators (1).…”

Section: Resultsmentioning

confidence: 99%

Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells

Matsuda

2011

Mol Med Report

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Abstract. SIRT1 is a mammalian candidate molecule involved in longevity and diverse metabolic processes. The present study aimed to determine the effects of certain herbs and spices on SIRT1 expression. Human cell lines Daudi, Jurkat, U937 and K562 were cultured in RPMI-1640. Herb and spice powders were prepared and the supernatants were collected. RT-PCR was used to quantify the expression level of the gene. Protein samples were then analyzed by Western blotting. Western blotting revealed the down-regulation of SIRT1 protein expression in Daudi cells treated with extracts of black pepper or turmeric. On the other hand, the effect on the SIRT1 gene expression examined by reverse transcription polymerase chain reaction was unaltered. In conclusion, component(s) of certain herbs and spices may induce the down-regulation of SIRT1 protein.

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Dietary activators of Sirt1

Cited by 85 publications

References 91 publications

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock

Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells

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