Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Sodagari, Hamid Reza; Farzaei, Mohammad Hosein; Bahramsoltani, Roodabeh; Abdolghaffari, Amir Hossein; Mahmoudi, Maryam; Rezaei, Nima

doi:10.1586/17474124.2015.1002086

Cited by 50 publications

(37 citation statements)

References 149 publications

(102 reference statements)

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“…Anthocyanins are an important subset of flavonoids and are ubiquitously distributed in many berries, such as strawberries, blueberries, cranberries, blackberries, and sunrouge buds. Anthocyanins play therapeutic and protective roles in the management of IBD by inducing anti-inflammatory cytokines, modulating TLR4, and improving the intestinal microbiota [211]. Another polyphenol, curcumin, a yellow agent derived from turmeric, has long been used in traditional medicines to treat inflammation and chronic diseases [212, 213].…”

Section: New Therapies Targeting Oxidative Stress In Ibdmentioning

confidence: 99%

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Tian

Wang

Zhang

2017

Oxidative Medicine and Cellular Longevity

499

363

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Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of IBD. This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response. In addition, potential therapeutic strategies for IBD that target oxidative stress signaling are reviewed and discussed. Though substantial progress has been made in understanding the role of oxidative stress in IBD in humans and experimental animals, the underlying mechanisms are still not well defined. Thus, further studies are needed to validate how oxidative stress signaling is involved in and contributes to the development of IBD.

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Section: New Therapies Targeting Oxidative Stress In Ibdmentioning

confidence: 99%

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Tian

Wang

Zhang

2017

Oxidative Medicine and Cellular Longevity

499

363

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“…Anthocyanins have been largely recognized by their potent antioxidant properties and ability to modulate crucial signalling pathways and gene regulation of several inflammatory enzymes and cytokines [5,9–13]. Therefore, beyond these modulatory roles, their antioxidant activity related to the capacity to scavenge reactive oxygen and nitrogen species or to activate cellular endogenous antioxidant systems [14,15], may be of major importance in countering the oxidative stress in IBD [16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model

Pereira

Figueiredo

et al. 2017

PLoS ONE

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Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms and efficacy as compared with established drugs still require more clarification. The main aim of this study was to compare the anti-inflammatory action of a chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L.), with that of 5-aminosalicylic acid (5-ASA), a first-line drug in IBD, in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model. Such fraction showed a high content and great molecular diversity of anthocyanins, with malvidin-3-galactoside and petunidin-3-arabinoside in the highest concentrations. After daily administration by intragastric infusion for 8 days, ARF, at a molar anthocyanin concentration about 30 times lower than 5-ASA, showed a higher effectiveness in counteracting the intestinal inflammation, as assessed by i) body weight variation and colon damage score, ii) reduction in leukocyte infiltration, iii) increase in antioxidant defenses and iv) by downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in colon tissue homogenates. The strong inhibition of COX-2 expression seems to be a crucial anti-inflammatory mechanism common to both ARF and 5-ASA, but the additional higher abilities of anthocyanins to downregulate iNOS and to decrease leukocytes infiltration and to increase antioxidant defenses in colon may account for the much higher anti-inflammatory action of anthocyanins. These data may contribute to the development of a promising natural approach in IBD management.

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“…Traditional and folklore approaches for the management of diseases are among the main alternative sources of medicine. However, in spite of the growing level of tendency towards traditional medicine, evidence for safety and effectiveness of these alternative medicines is limited . Although conventional treatments of RA commonly alleviate the symptoms, high incidence of adverse reactions of these drugs has resulted in exploration of alternative methods, particularly traditional remedies, for symptomatic relief of RA.…”

Section: Discussionmentioning

confidence: 99%

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

Farzaei

Abdollahi

et al. 2016

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease, which affects synovial tissue in multiple joints. Although conventional treatments of RA commonly alleviate the symptoms, high incidence of adverse reactions leads to research tendency towards complementary and alternative medicine. As various medicinal plants are traditionally used for the management of symptomatologies associated with RA in Persian medicine, we reviewed medicinal literature to confirm their efficacy in the management of RA. Key findings Scientific evidence revealed that traditional medicaments exert beneficial effects on RA through several cellular mechanisms including downregulation of pro-inflammatory cytokines such as TNF-a, IL-6 and NF-jB, suppression of oxidative stress, inhibition of cartilage degradation with destructive metalloproteinases and enhancement of antioxidant performance. Various active constituents from different chemical categories including flavonols, lignans, coumarins, terpenes, glycosylflavons, dihydroflavonols, phytoestrogens, sesquiterpene lactones, anthraquinones, alkaloids and thymoquinones have been isolated from the medicinal plants. Summary The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs.

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Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Cited by 50 publications

References 149 publications

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

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