Dietary Arginine:Lysine Ratio and Methionine Activity at Elevated Environmental Temperatures

Balnave, D.; Hayat, Javed; Brake, J.

doi:10.1093/japr/8.1.1

Cited by 30 publications

(16 citation statements)

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“…This plasma amino acid imbalance may then result in lower feed intake in birds fed DLM, but not in those fed HMB since the latter would be quickly internalized into tissues mainly by diffusion, metabolized to methionine, and partially utilized by cells before reaching the plasma amino acid pool in the form of methionine (Dibner 2003). Nevertheless, in theory, if methionine levels are high relative to Arg, increasing dietary Arg would be beneficial to DLM-fed birds, rather than detrimental, as observed in the trials of Balnave et al (1999) and Chen et al (2003) since increasing Arg aids in eliminating excessive methionine through the creatine metabolic pathway in both thermoneutral and hyperthermic birds (Keshavarz and Fuller 1971a, b;Chamruspollert 2001). In the current experiment, feed consumption was not affected by Met source at any time (P > 0.1), and yet an interaction between Met source and Arg was found for BWG and FCR (P < 0.007) after a prolonged Fig.…”

Section: Discussionmentioning

confidence: 97%

“…Balnave et al (1999) concluded that low Arg:Lys may optimize performance in birds under tropical environments when fed DLM but not for those fed HMB. In agreement with this observation, Balnave and Oliva (1990), using low Arg:Lys (approximately 0.95), observed impaired FCR (P < 0.05), numerically lower BWG (P > 0.05) and no changes in the feed intake in hyperthermic birds fed HMB vs. their counterparts fed DLM.…”

Section: Discussionmentioning

confidence: 99%

“…Since Balnave and Brake (1999) observed that when a diet high in Arg:Lys (1.36) was fed to hyperthermic birds, plasma Arg:Lys increased only when NaHCO 3 was added to the diet. In the current trial, the observation that birds fed DLM and NaHCO 3 in diets with Arg:Lys of 1.40 had the lowest BWG and an impaired FCR whereas birds fed HMB without NaCHO 3 had an impaired FCR (Table 3) suggests the possibility of high Arg and methionine levels in blood and/or tissues, which may be detrimental to heat-stressed chickens.…”

Section: Discussionmentioning

confidence: 99%

“…Balnave et al (1999) showed reduced BWG and feed consumption in chronically heat-stressed birds (32°C) when DLM was used in diets with high Arg:Lys (1.34). Birds fed HMB were unaffected by Arg supplementation.…”

Section: Table 3 Effect Of Feeding 2-hydroxy-4-(methylthio) Butanoicmentioning

confidence: 97%

“…Balnave and Brake (1999) reported a decrease in plasma Lys when NaHCO 3 was supplemented to birds under HS. These authors also observed that the only birds showing increased plasma Arg:Lys, in response to a Arg:Lys of 1.36, were those supplemented with NaHCO 3 .…”

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Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers

González-Esquerra¹,

Leeson²

2006

Can. J. Anim. Sci.

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Gonzalez-Esquerra, R. and Leeson, S. 2006. Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers. Can. J. Anim. Sci. 86: 263-271. In two experiments, the effects of arginine:lysine, NaHCO 3 and methionine source on performance and amino acid digestion of heat-stressed broilers were studied. In exp. 1, corn/soy diets with argine:lysine (Arg:Lys) of 1.10, 1.25 and 1.40 were fed from 21 to 42 d. Diets were supplemented with 2-hydroxy-4-(methylthio)-butanoic acid (HMB) or DL-Methionine (DLM) with NaHCO 3 at 0 or 1.04%. Ten replicates per treatment of four birds per cage were maintained at 31.7 ± 0.9°C. From 21 to 28 d weight gain (BWG), feed consumption and feed-to-gain (FCR) were unaffected by diet treatment. Methionine source did not influence bird performance (P > 0.05). However, from 35 to 42 d, when diets were supplemented with NaHCO 3 , BWG and FCR of birds fed DLM were compromised when offered diets with Arg:Lys at 1.40. In diets devoid of NaHCO 3 , increasing Arg:Lys to 1.25 impaired BWG and FCR for broilers fed DLM, although effects disappeared when more Arg was used. Performance of birds on HMB was mostly unaffected by Arg:Lys or NaHCO 3 except when fed diets void of NaHCO 3 with Arg:Lys of 1.40, when FCR was impaired. In exp. 2, broilers were maintained at thermoneutrality (TN) reaching 20°C at 33 d. Other birds were at 31°C throughout, representing chronic heat stress (CHS), while a third group changed suddenly from 20 to 31°C at 25 d representing acute heat stress (AHS). Birds within each environment were housed in one of two rooms with eight replicates of four birds per treatment. At 25 d, birds were fed Arg:Lys of 0.95 or 1.40 with DLM supplemented at requirement. Birds fed Arg:Lys of 1.40 were also offered diets with synthetic L-methionine (L-Met). Adding L-Met to high Arg diets during CHS significantly depressed ileal digestibility of all amino acids (P < 0.05). It is concluded that chronic heat stress can affect the digestibility of amino acids, and that this effect may impact performance.Key words: Broilers, methionine, arginine, heat stress, digestibility, sodium bicarbonate Gonzalez-Esquerra, R. et Leeson, S. 2006. Incidence de la source d'arginine:lysine sur la digestibilité des acides aminés et réaction aux électrolytes des aliments chez les poulets de chair soumis à un stress thermique chronique ou aigu. Can. J. Anim. Sci. 86: 263-271. Les auteurs ont imaginé deux expériences pour vérifier l'incidence de la source d'arginine:lysine, du NaHCO 3 et de la méthionine sur la digestion des acides aminés et le rendement des poulets de chair soumis à un stress thermique. Dans le cadre de la première expérience, ils ont servi une ration de maïs et de soja contenant un ratio d'arginine:lysine (Arg:Lys) de 1,10, 1,25 ou 1,40 aux volatiles du 21 e au 42 e jour. La ration était enrichie d'acide 2-hydroxy-4-(méthylthio)-butanoïque (HMB) ou de DL-méthionine (DLM) assortie de NaHCO 3 à 0 ou à 1,04 %. L...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Table 3 Effect Of Feeding 2-hydroxy-4-(methylthio) Butanoicmentioning

confidence: 97%

mentioning

confidence: 99%

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Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers

González-Esquerra¹,

Leeson²

2006

Can. J. Anim. Sci.

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Response of sunshine bass (Morone chrysops x M. saxatilis) to digestible protein/ dietary lipid density and ration size at summer culture temperatures in the Southern United States

et al. 2012

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The effect of methionine and folic acid administered in ovo on the hematological parameters of chickens (Gallus gallus domesticus)

et al. 2020

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Methionine ( Met ), an essential amino acid in poultry diets, when overdosed may cause hyperhomocysteinemia, which is mainly a trigger for cardiovascular diseases in humans. Homocysteine is neutralized (remethylated) in the presence of folic acid ( FA ), which also plays an important role in hematopoiesis and participates in the synthesis of DNA, and its deficiencies may result in the development of neural tube defects. One of the basic tools in studying the impact of both xenobiotics and nutrients on the animal organism is hematological analysis. Thus, the aim of this study was to determine the effect of in ovo supplementation with Met and FA on the hematological parameters of broiler chickens. On the 17th day of incubation, embryonated eggs (Ross 308) were injected with 5 or 25 mg of Met per egg (M5 and M25), 3 and 15 mg of FA per egg (F3 and F15), or a mixture of these 2 compounds (M5/F3 and M25/F15). The broilers were reared in accordance with welfare regulations and fed with commercial diets ad libitum . Blood samples were collected on the first, seventh, and 35th day of rearing (D1, D7, and D35), and complete hematological analysis was performed. The observed changes in red blood cell parameters probably result from physiological changes occurring during bird growth. Mean erythrocyte volume decreased with the age of chickens in the control, M5, and M25 groups, but not in those supplied with FA. Among supplemented groups, the number of white blood cells on D1 was lower only in group M5 than in the sham (C) group. The analysis of leukograms showed no significant differences between the groups. Comparing D1 with D7 in the group injected with a higher dose of Met and FA (MF25/15), a statistically significant increase in the percentage of lymphocytes and a significant decrease in the percentage of heterophils were observed. In addition, in the group injected with a higher FA dose (F15), there was statistically significant reduction in the percentage of eosinophils and a significant increase in the percentage of monocytes at day 7 compared with day 1. It seems that Met supplementation led to temporary immunosuppression in the animals.

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Dietary Arginine:Lysine Ratio and Methionine Activity at Elevated Environmental Temperatures

Cited by 30 publications

References 16 publications

Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers

Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers

Response of sunshine bass (Morone chrysops x M. saxatilis) to digestible protein/ dietary lipid density and ration size at summer culture temperatures in the Southern United States

The effect of methionine and folic acid administered in ovo on the hematological parameters of chickens (Gallus gallus domesticus)

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