Dietary calcium decreases plasma cholesterol by down‐regulation of intestinal Niemann–Pick C1 like 1 and microsomal triacylglycerol transport protein and up‐regulation of CYP7A1 and ABCG 5/8 in hamsters

Ying, Ka; Yang, Nian‐Yun; Jiao, Rui; Peng, Cheng; Guan, Lei; Huang, Yü; Chen, Zhenyu

doi:10.1002/mnfr.201000161

Cited by 58 publications

(65 citation statements)

References 28 publications

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“…Supplementation of calcium in the diet is beneficial to lower cholesterol levels by inhibiting intestinal NPC1L1, activating CYP7A1, and increasing bile acid excretion via feces. (7,25) Meanwhile, there are still many substances in honey which have not been scientifically proven to be beneficial in lowering blood cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Nurmasitoh

Pramaningtyas

2016

UnivMed

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BACKGROUNDCoronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia. One of the natural products that has been developed for the treatment of hypercholesterolemia is honey. Honey contains fructooligosaccharides, various vitamins, minerals, and enzymes which are supposedly able to lower blood cholesterol levels. This research aimed to study the influence of honey on the levels of blood total cholesterol, triglyceride, and low density lipoprotein (LDL) levels in Wistar rats. METHODSThis study was of experimental post test control group design. Twentyfour male Wistar rats (Rattus norvegicus) were randomly divided into 4 groups. K1 was the negative control group (with normal diet), K2 was the positive control group (with high-fat diet), P1 was fed a high-fat diet for 7 days, followed by high-fat diet plus honey for the next 7 days. P2 was fed a high-fat diet for 7 days, followed by regular diet plus honey for the next 7 days. After completion of this treatment, total cholesterol, triglycerides, and LDL levels were measured by the cholesterol oxidase phenol+aminophenazone (CHOD-PAP) method using enzymatic spectrophotometry principles. RESULTSThere were significant differences in total cholesterol, triglyceride, and LDL levels between all groups after day 15 (p<0.05). CONCLUSIONHoney supplementation was able to reduce the blood levels of total cholesterol, triglycerides, and LDL. Honey supplementation accompanied by non-cholesterol feeds could more effectively lower total cholesterol, triglycerides, and LDL serum levels in Wistar rats. Keywords

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Section: Discussionmentioning

confidence: 99%

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Nurmasitoh

Pramaningtyas

2016

UnivMed

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“…Calcium can be bound to fatty acids and bile acids in the gut by bile salt hydrolase; thus, interfering with lipid absorption [47,48]. In addition to these intestinal effects, an HDL-cholesterol-increasing effect of calcium via a reduction in plasma cholesteryl ester transport protein (CETP) has also been suggested [49]. Enhancing calcium intake via milk consumption could increase serum HDL-cholesterol by decreasing CETP activity.…”

Section: Discussionmentioning

confidence: 99%

Dietary changes in Vietnamese marriage immigrant women: The KoGES follow-up study

Hwang

Lee

et al. 2014

Nutr Res Pract

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BACKGROUND/OBJECTIVESThe immigrant population has grown considerably in South Korea since the early 1990s due to international marriages. Dietary changes in immigrants are an important issue, because they are related to health and disease patterns. This study was conducted to compare changes in dietary intake between baseline and follow-up periods.SUBJECTS/METHODSTwo hundreds thirty three Vietnamese female married immigrants. Baseline data were collected during 2006-2009, and the follow-up data were collected during 2008 and 2010. Food consumption was assessed using a 1-day 24-hour recall.RESULTSThe amount of the total food consumed (P < 0.001) including that of cereals (P = 0.004), vegetables (P = 0.003), and fruits (P = 0.002) decreased at follow-up compared to that at baseline, whereas consumption of milk and dairy products increased (P = 0.004). Accordingly, the overall energy and nutrient intake decreased at follow-up, including carbohydrates (P = 0.012), protein (P = 0.021), fiber (P = 0.008), iron (P = 0.009), zinc (P = 0.006), and folate (P = 0.002). Among various anthropometric and biochemical variables, mean skeletal muscle mass decreased (P = 0.012), plasma high density lipoprotein-cholesterol increased, (P = 0.020) and high sensitivity C-reactive protein decreased at follow-up (P < 0.001).CONCLUSIONSA long-term follow-up study is needed to investigate the association between changes in food and nutrient intake and anthropometric and biochemical variables in these Vietnamese female marriage immigrants.

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“…Real-time PCR analysis of mRNA of hepatic SREBP-2, LDLR, HMG-CoA Reductase, LXRa, CYP7A1, ABCG5, ABCG8, MTP and small intestine NPC1L1, ABCG5, ABCG8, ACAT2, MTP Each mRNA level was determined as previously described [14]. Total RNA from liver or intestine was extracted and isolated using Trizol Ò Reagent (Invitrogen, Carslbad, CA); total RNA from the liver and intestine was converted to its cDNA using a high capacity cDNA reverse transcription kit (Applied Biosystems, Foster City, CA).…”

Section: Liver Cholesterolmentioning

confidence: 99%

“…Total liver cholesterol was determined as previously described [14,15]. In brief, the liver lipids were extracted using a solvent mixture of chloroform: methanol with 5a-cholestane being used as an internal standard.…”

Section: Liver Cholesterolmentioning

confidence: 99%

Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet

et al. 2012

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Dietary calcium decreases plasma cholesterol by down‐regulation of intestinal Niemann–Pick C1 like 1 and microsomal triacylglycerol transport protein and up‐regulation of CYP7A1 and ABCG 5/8 in hamsters

Abstract: Beneficial modification of lipoprotein profile by dietary calcium was mediated by sequestering bile acid absorption and enhancing excretion of fecal cholesterol, via up-regulation of mRNA CYP7A1 and intestinal ABCG 5/8 with down-regulation of mRNA NPC1L1 and MTP.

Cited by 58 publications

References 28 publications

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Dietary changes in Vietnamese marriage immigrant women: The KoGES follow-up study

Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet

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