Dietary chitosan supplementation attenuates isoprenaline-induced oxidative stress in rat myocardium

Anandan, R.; Ganesan, B.; Obulesu, T; Mathew, Suseela; Kumar, RB Suresh; Lakshmanan, P.T.; Zynudheen, A.A.

doi:10.1016/j.ijbiomac.2012.07.016

Cited by 28 publications

(13 citation statements)

References 32 publications

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“…Researchers from Hubei University of Medicine, China, reported that COS inhibit ethanol-induced lipid peroxidation and glutathione depletion via the transcriptional activation of nuclear factor erythroid-2-related factor-2 (Nrf2) and reduction of the ethanol-induced phosphorylation of p38 MAPK, JNK and ERK [ 47 ]. Dietary chitosan supplementation attenuates isoprenaline-induced oxidative stress in rat myocardium [ 48 ] and the antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats has been reported [ 49 ]. COS protect mice from oxidative stress [ 50 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Kerch

2015

Marine Drugs

105

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Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.

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Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Kerch

2015

Marine Drugs

105

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“…The extensive studies of biological activities of COS have shown that COS could be an effective alternative to antibiotics as a growth-promoter in livestock and poultry diets. The effects of COS on growth [6], immunity [7], antimicrobial activity [8], attenuating oxidative stress [9] and hypolipidemic activities [10] have been described, particularly the anti-inflammatory activities of COS both in vitro [11] and in vivo [12]. The anti-inflammatory effect of COS in vitro has been shown to positively correlate with its molecular weight (MW) and degree of deacetylation (DD) [13].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Effects of dietary administering chitosan on growth performance, jejunal morphology, jejunal mucosal sIgA, occluding, claudin-1 and TLR4 expression in weaned piglets challenged by enterotoxigenic Escherichia coli

Xiao¹,

Tang²,

Yin³

et al. 2013

International Immunopharmacology

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“…Numerous studies have shown that chitosan has beneficial effects on relieving the oxidative stress [8]. Moreover, placenta, as the main interface between the mother and the fetus, has many functions to perform, including producing and secrete hormones and cytokines, and mediatting the transfer of nutrients, oxygen and waste products [9].…”

Section: Introductionmentioning

confidence: 99%

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

Xie

Long

et al. 2016

BMC Vet Res

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BackgroundChitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme’s activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined.ResultsResults showed that maternal dietary supplementation with COS increased (P < 0.05) plasma total SOD, caused a downtrend in plasma MDA (0.05 < P < 0.10) on d 110 of gestation. Interestingly, the mRNA expression of some antioxidant genes in the placenta were increased (P < 0.05) and pro-inflammatory cytokines were reduced (P < 0.05) by COS supplement, whereas no significant difference was observed in the activities of placental total SOD and CAT between two groups. Additionally, further study demonstrated that COS feeding stimulated mTOR signaling pathway, increased amino acids transporters expression in placenta.ConclusionsThese observations suggested that COS supplement in sow’s diet during late gestation enhanced antioxidant defense capacity of sows, promoted placental amino acids transport, which may contribute to the health of sows and development of fetus during gestation.

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Dietary chitosan supplementation attenuates isoprenaline-induced oxidative stress in rat myocardium

Cited by 28 publications

References 32 publications

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Effects of dietary administering chitosan on growth performance, jejunal morphology, jejunal mucosal sIgA, occluding, claudin-1 and TLR4 expression in weaned piglets challenged by enterotoxigenic Escherichia coli

Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

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