Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats

Pragasam, Samuel Joshua; Rasool, Mahaboobkhan

doi:10.1007/s00011-013-0602-7

Cited by 47 publications

(34 citation statements)

References 41 publications

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“…p-CA also decreased the ROS levels, but no statistical difference was found. In conjunction with previous reports and our results that QC and p-CA inhibited Aβ-induced microglial activity, suppressed ROS production, and inhibited NF-κB activity in BV-2 microglial cells48,49,50 , we may conclude that the structures of kaempferol and p-CA played a vital role in inhibiting neuroinflammation.…”

supporting

confidence: 81%

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Yang

Liu

Lü

et al. 2016

ACS Chem. Neurosci.

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Accumulating evidence suggested that soluble oligomeric β-amyloid protein (Aβ) exerts diverse roles in neuronal cell death, neuroinflammation, oxidative stress, and the eventual dementia associated with Alzheimer's disease (AD). Developing an agent with multiple properties may be a reasonable strategy for the treatment of AD. In this study, we isolated a novel multifunctional compound named camellikaempferoside B (YCF-2) from Fuzhuan brick tea. YCF-2 consists of kaempferol backbone, p-coumaric acid (p-CA) group, and a novel structure of rhamnopyranosyl group at the C-4' position, possessing the properties of both kaempferol and p-CA. YCF-2 significantly inhibited Aβ production by decreasing β-secretase activity. Moreover, YCF-2 suppressed Aβ42 fibrillation and facilitated nontoxic oligomer formation by binding to Aβ42 oligomers and by blocking the conformational transition to β-sheet. Furthermore, YCF-2 ameliorated Aβ-induced neuronal cell death, ROS production, inflammatory factor release, and microglia activation by blocking the NF-κB signaling pathway in microglia. These findings indicated that YCF-2 with a novel lead structure has potential applications for drug development for AD treatment.

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supporting

confidence: 81%

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Yang

Liu

Lü

et al. 2016

ACS Chem. Neurosci.

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“…59 It has been shown that p-CA suppresses the infl ammation caused by monosodium urate crystals in rats. 60 P-CA has been shown the immunomodulatory and anti-infl ammatory effect on experimental infl ammation in rats. 61 In this study, oxidant-antioxidant and infl ammation parameters in the R-IR injury model using p-CA were examined by biochemical method.…”

Section: Discussionmentioning

confidence: 97%

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Güzel

Tanyeli

2018

Sakarya Medical Journal

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Aim The aim of this study is to evaluate the antioxidant effect of p-Coumaric Acid (p-CA) on tissue damage due to ischemia-reperfusion in rat kidney tissue. ( Sakarya Med J 2018, 8(3):625-631)Methods Thirty-two 12-16 week-old Wistar Albino female rats weighing 200-250 g were used in this study. Rats underwent right nephrectomy intraperitoneally with an incision made in the dorsal region under ketamine (75 mg/kg) and xylazine (8 mg/kg) anesthesia. These rats were randomly divided into four groups in equal numbers (n = 8). Groups were classifi ed as the sham (S), renal ischemia-reperfusion (R-IR), 50 mg/kg p-CA with R-IR (p-CA 50), and 100 mg/kg p-CA with R-IR (p-CA 100). After the dorsum of all rats was opened and the right nephrectomy was performed, all groups except sham were clamped on the left renal artery and ischemia and reperfusion protocol was performed. P-CA was administered in two doses, 60 min before ischemia and 30 min before reperfusion. Total antioxidant levels (TAS), total oxidant level (TOS), superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO) levels of left kidney were measured spectrophotometrically, and oxidative stress index (OSI) was calculated.Results TOS, MDA, MPO, and OSI values increased in R-IR group compared to S (p <0.01), while TAS and SOD values decreased. Increase in TAS and SOD values, a decrease in TOS, MDA, MPO, and OSI values were observed in P-CA applied groups (p <0.05).Conclusion Our fi ndings indicate that p-CA administration in renal ischemia-reperfusion injury may play a role in protecting tissue by reducing oxidant damage.

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“…Flavonoids are leading miscellaneous assembly of phytonutrients to present virtually almost in all fruits and vegetable with more than 6000 types [13]. The flavonoids basic structure of comprises of a frame of diphenyl propane, having two aromatic benzene (ring A and B) allied through a three carbon chain which forms a closed pyran ring using benzene A ring [15].…”

Section: Flavonoidsmentioning

confidence: 99%

“…Glycoside forms consist of two types of di-glycosides, L-rhamnosylglucosyl derivatives, which are classified as neohesperidosides and rutinosides, connected through 1,2 or 1,6 inter glycosidic bond, respectively. It had excellent potential to control Citrus: An Ancient Fruits of Promise for Health Benefits http://dx.doi.org/10.5772/intechopen.79686 many chronic diseases and suppressed the infectious in the body [13,14]. The classification of flavonoids showed in Figure 2.…”

Section: Flavonoidsmentioning

confidence: 99%

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Citrus: An Ancient Fruits of Promise for Health Benefits

Ahmed¹,

Azmat²

2019

Citrus - Health Benefits and Production Technology

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Citrus is a group of fruit species, comprise an impressive list of additional vital nutrients, quite heterogeneous in many aspects and ancient times used to prevent and cure different diseases of the human body. It has a range of bioactive chemicals which is suitable for balanced diet and health. Citrus is one of the most important fruit in the world for health-related elements. Some species of the citrus act as a source of potential antioxidant showed prevention against heart diseases, anticancer, inflammation, antiviral, antibacterial and antifungal activity. Citrus fruit contained a higher level of flavonoids, terpenes, phytonutrients and range of phenolic compounds, vitamins C and carotenoids. These biochemicals are present in fruit rag, juice, seed and peel. The biocompounds present in citrus depend upon production, species to species. The aims and objectives of this chapter are to highlight the primary bioactive compounds in citrus and their role in controlling of diseases of a human.

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Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats

Abstract: The results of this study reveal the potential anti-inflammatory effect of p-Coumaric acid against monosodium urate crystal-induced inflammation in rats.

Cited by 47 publications

References 41 publications

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Citrus: An Ancient Fruits of Promise for Health Benefits

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