Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status

Abstract

The larval stage is highly prone to stress due to the ontogenetic and metabolic alterations occurring in fish. Curcumin inclusion in diets has been shown to improve growth by modulating oxidative status, immune response, and/or feed digestibility in several fish species. The aim of the present work was to assess if dietary curcumin could promote marine fish larvae digestive maturation and improve robustness. Gilthead seabream larvae were fed a diet supplemented with curcumin at dose of 0 (CTRL), 1.5 (LOW), or 3.0 g/Kg feed for 27 days. From 4 to 24 days after hatching (DAH), no differences were observed in growth performance. At the end of the experiment (31 DAH) LOW larvae had a better condition factor than CTRL fish. Moreover, HIGH larvae showed higher trypsin and chymotrypsin activity when compared to CTRL fish. LOW and HIGH larvae were able to maintain the mitochondrial reactive oxygen species production during development, in contrast to CTRL larvae. In conclusion, curcumin supplementation seems to promote larvae digestive capacity and modulate the oxidative status during ontogeny. Furthermore, the present results provide new insights on the impacts of dietary antioxidants on marine larvae development and a possible improvement of robustness in the short and long term.

Dietary Strategies to Modulate the Health Condition and Immune Responses in Gilthead Seabream (Sparus aurata) Juveniles Following Intestinal Inflammation

“…In fact, lipid peroxidation was significantly increased in fish fed CTRL-D and BG-D while curcumin was able to improve the intestinal response to lipid peroxidation induced by the DSS chemical and tended to increase the sod and gpx transcripts. Curcumin has a strong ability to stimulate antioxidant enzyme activities and to inhibit lipid peroxidation [ 40 , 44 , 45 , 47 , 50 , 51 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ], reducing the levels of ROS and NOS, responsible for the breakdown of intestinal tight junctions, tissue injury, and necrosis [ 71 ]. An increase in the relative mRNA expression of sod , cat , gpx , gr , and gst after curcumin supplementation was found in previous studies [ 44 , 78 ].…”

Effective role of dietary curcumin nanoparticles and Spirulina platensis supplementation on growth, digestive enzymes, hematological, serum biochemical parameters, antioxidant status, immune responses, and histological examination in Nile tilapia fingerlings

“…A holistic view is documented between the antioxidant property and sh immunity. Antioxidative enzymes, such as SOD, CAT, and GPx protect the cellular components from oxidative stress through induce the reduction of ROS into less reactive approach (Xavier et al, 2021). The product marker of lipid peroxidation, MDA indicates the oxidative damages to the lipids.…”

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

“…As a result, this developmental stage in fish is also associated with oxidative stress [115]. Xavier et al [116,117] suggested that the inclusion of curcumin in the diet of gilthead seabream postlarvae could improve their health status, enhance robustness, and increase their total antioxidant capacity and digestive capacity, while reducing protein oxidative damage and oxidative stress throughout ontogeny. ↑SOD, ↑CAT, ↑GPx, ↓MDA.…”