Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice

Sánchez-Fidalgo, Susana; Cárdeno, Ana; Sánchéz-Hidalgo, Marina; Aparicio‐Soto, Marina; Lastra, Catalina Alarcón de la

doi:10.1016/j.jnutbio.2012.11.008

Cited by 124 publications

(113 citation statements)

References 75 publications

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“…In our study, EVOO contained 718 mg/kg of oil of total phenols, resulting in a daily dose of 4.3 mg/kg/bw. This level is similar to that reached by Sánchez-Fidalgo et al[13] with an EVOO enriched with a polyphenol extract (3.5 mg/kg/bw). However, in our EVOO, the concentration of hydroxytyrosol was 15 mg/kg of oil, resulting in a daily dose of only 90 µg/kg bw.…”

Section: Discussionsupporting

confidence: 89%

“…However, in our EVOO, the concentration of hydroxytyrosol was 15 mg/kg of oil, resulting in a daily dose of only 90 µg/kg bw. This dose is much lower than that provided in the study of Sánchez-Fidalgo et al[13], which we calculated to be approximately 400 µg/kg/bw. In another study from Sánchez-Fidalgo et al [12], the daily dose of hydroxytyrosol in the hydroxytyrosol-enriched EVOO group was even higher (5 mg/kg/bw).…”

Section: Discussioncontrasting

confidence: 56%

“…In contrast, in a DSS-induced chronic colitis in mice, Sánchez-Fidalgo et al[13] reported that a diet containing 10% of EVOO enriched with a polyphenol extract reduced histopathological colitis scores and inflammatory markers. They also demonstrated that dietary EVOO and EVOO enriched with hydroxytyrosol reduced the severity of chronic colonic damage induced by an acute exposure to DSS [12].…”

Section: Discussionmentioning

confidence: 99%

“…Although multiple sources of evidence support the anti-inflammatory effect of olive oil and its phenolic compounds [3], their beneficial effects in inflammatory bowel disease (IBD) have been almost exclusively studied in animal models of chemically induced colitis and involved the reduction of COX-2 and iNOS expression [12, 13]. However, such animal models do not accurately reflect the human disease pathogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Bigagli¹,

Toti²,

Lodovici³

et al. 2018

Lifestyle Genomics

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Background: Human studies have demonstrated that olive oil phenolic compounds reduce inflammatory markers associated with chronic diseases. Objectives: To explore the anti-inflammatory effects of extra-virgin olive oil polyphenols in an experimental model of inflammatory bowel disease (IBD). Methods: HLA-B27 transgenic rats were fed an AIN-76 diet containing 10% corn oil (CO) or extra-virgin olive oil with high (EVOO) or low phenolic content (ROO) for 3 months. Wild-type rats (WT) were fed the CO diet. Results: CO-fed HLA-B27 animals developed intestinal inflammation characterized by diarrhea, increased myeloperoxidase activity, and mucosal injury. None of these parameters were influenced by EVOO. Gene expression profiling indicated that proinflammatory pathways were upregulated in the colon mucosa of CO-fed HLA-B27 rats compared to WT, and this was further confirmed by RT-PCR for the iNOS, TNFα, and IL1β genes. EVOO significantly reduced TNFα gene expression in the colon mucosa and decreased total cholesterol blood levels compared to CO HLA-B27 rats (89.43 ± 3.66 vs. 111.5 ± 8.10 mg/dL, p < 0.05). This latter effect with EVOO was associated with reduced HMGCR and increased PPAR-α hepatic gene expression, compared to ROO. Conclusion: These data indicate that olive oil polyphenols do not control colon inflammation in HLA-B27 transgenic rats but exert a positive effect on blood lipids by reducing total cholesterol levels. This preliminary result suggests the need to explore the efficacy of EVOO rich in polyphenols as a complementary strategy for managing hypercholesterolemia and to potentially limit statin-associated myotoxicity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Bigagli¹,

Toti²,

Lodovici³

et al. 2018

Lifestyle Genomics

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“…Thus, MUFAs can reproduce a number of the anti-inflammatory effects of TLR4 or induce TNF-α inhibition [25], which suggest that dietary MUFAs constitute an attractive nutritional approach for the treatment of MS.…”

Section: Introductionmentioning

confidence: 99%

Dietary Fatty Acids and Vitamin B3: An Effective Treatment Strategy for the Metabolic Syndrome?

Paz¹,

López

Ortega‐Gómez³

et al. 2014

J Food Nutr Disor

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The metabolic syndrome (MS) may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension. Recent evidences suggest that, primarily due to its high monounsaturated fatty acids (MUFAs) content, olive oil and omega-3 polyunsaturated fatty acids (PUFAs) could be useful as a dietary approach for MS management, with relevance in the postprandial state. Vitamin B3, as a major substrate for nicotinamide phosphoribosyltransferase (NAMPT), also constitutes a nutritional intervention strategy for the treatment of MS. NAMPT has been shown to exert activities of central importance to cellular energetics and innate immunity. Within the cell, NAMPT is the rate-limiting step in a salvage pathway of nicotinamide adenine dinucleotide (NAD+) biosynthesis. NAMPT has been shown to correlate with triglycerides in the fasting plasma, and a potential regulatory role for fatty acids on NAMPT expression has been proposed. Whether different dietary fatty acids, including olive oil as a source of MUFA, play a role in NAMPT excursions and in the NAMPT-dependent regulation of glucose and lipid metabolism and inflammation states remains to be solved. In general, the mechanisms that alter NAD+ metabolism probably include multiple processes, but the understandings of these mechanisms are currently very unclear and a considerable effort in this area is required before we know how changes in NAD+ metabolism influence physiology of glucose and lipid metabolism and how NAD+ metabolism might be manipulated for healing benefit by specific dietary fatty acids as a therapeutic treatment for MS.

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Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches

Mosele

Martín‐Peláez

Macià

et al. 2014

Molecular Nutrition Food Res

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Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice

Cited by 124 publications

References 75 publications

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Dietary Fatty Acids and Vitamin B3: An Effective Treatment Strategy for the Metabolic Syndrome?

Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches

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