Dietary factors associated with subclinical inflammation among girls

Bibiloni, María del Mar; Maffeis, Claudio; Llompart, Isabel; Pons, Antoni; Tur, Josep A.

doi:10.1038/ejcn.2013.196

Cited by 39 publications

(48 citation statements)

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“…21 Therefore, the absence of an association in the active group could be mediated partially by the association between sport practice and better eating behaviors in adolescents. 21,23 In the present study, the relationship between inflammation and HDL-c could also explain the findings related to vascular structure in the active group. Physical activity of the group engaged in sports was marginally related to HDL-c, which modulates the phosphorylation of the endothelial nitric oxide synthase and would protect the artery wall through lower blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…Eating behaviors have been suggested as important confounders in the relationship between inflammation and the lipid profile. 20,21 Consumption of some foods seems to control oxidative stress through DNA methylation, 22 and some dietary patterns affect proinflammatory markers in pediatric populations. 21 Therefore, the absence of an association in the active group could be mediated partially by the association between sport practice and better eating behaviors in adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 Consumption of some foods seems to control oxidative stress through DNA methylation, 22 and some dietary patterns affect proinflammatory markers in pediatric populations. 21 Therefore, the absence of an association in the active group could be mediated partially by the association between sport practice and better eating behaviors in adolescents. 21,23 In the present study, the relationship between inflammation and HDL-c could also explain the findings related to vascular structure in the active group.…”

Section: Discussionmentioning

confidence: 99%

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The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Cayres

Lira

Machado‐Rodrigues

et al. 2015

The Journal of Pediatrics

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Objective To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice. Study designThe sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 AE 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity.Results In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipopro- H igh-sensitivity C-reactive protein (hsCRP) is an acute-phase protein produced by the liver in response to interleukin-6, which is directly related to vascular inflammation.1,2 During the atherosclerotic process, hsCRP is associated with greater permeability of the intima layer through stimuli of intercellular/vascular cell adhesion molecules. hsCRP also acts in processes related to oxidation of lipoproteins in the vascular wall.2,3 Strategies to counteract inflammation status commonly include both pharmacologic and nonpharmacologic strategies. In the latter, lifestyle changes frequently are used, especially improved diet, giving up smoking, and practicing physical exercise. 4 Q5Indeed, physical exercise at moderate intensity plays an anti-inflammatory role. 4,5 Its prolonged practice has been linked to the control the progression of intima-media thickness (IMT) in hypertensive adults 6 and also in healthy adolescents. 7,8Recently, studies have reported that behavioral variables can modulate the relationship between the progression of artery IMT and its risk factors.9,10 For instance, smoking exacerbates the relationship between age and the metabolic syndrome components and age and carotid IMT (cIMT) in young adults. 10 In contrast, the same harmful effect related to age has been observed relating to physical inactivity.9 However, physical inactivity seems to exacerbate the relationship between cIMT Q6and overweight, blood pressure, and dyslipidemia in adults. 9The objective of the present study was to analyze the relationship between hsCRP and the lipid profile, blood flow, and artery IMT in prepubertal adolescents who were stratified according to their engagement in sports practice. It was hypothesized that inflammation would be positively and strongly related to cardiovascular/metabolic outcomes in inactive youth compared with the active ones, independent of body fatness and biological maturation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Cayres

Lira

Machado‐Rodrigues

et al. 2015

The Journal of Pediatrics

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“…While antioxidant vitamins [19,20] and polyunsaturated fatty acids [19] seem to have anti-inflammatory properties, total fat [20] and saturated fat acids [19,20] seem to be pro-inflammatory. Moreover, a Western dietary pattern is considered to be proinflammatory diet [19].…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

et al. 2017

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Background/objectives The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents.Subjects/methods The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models.Results DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95% CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95% CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95% CI:2.00-15.78, p trend = 0.002).Conclusions DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.

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“…Finally, a Spanish study on obese children from 12 to 17 years of age showed that adiposity measures such as the body mass index (BMI) and waist-to-hip ratio were significant predictors of serum levels of hs-CRP or leptin, and concentrations of adiponectin were positively linked to a Mediterranean dietary pattern [57].…”

Section: Inflammation and Dietary Patternsmentioning

confidence: 99%

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

Casas¹,

Estruch²

2016

Immunome Res

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The World Health Organization (WHO) recognizes that diet plays an important role in the prevention of several non-infectious diseases. Unhealthy diets that include high intake of red and processed meat, sweets and desserts, potatoes, French fries, and refined grains) is associated with high plasma inflammatory biomarkers and a greater risk of cardiovascular disease (CVD), type 2 diabetes (T2D), cancer and other chronic diseases. On the other hand, prudent dietary patterns such as Mediterranean diet as well as intake of fruit, vegetables, extra virgin olive oil, walnuts, legumes, whole grains, fish, cocoa, coffee, tea and wine is associated with a reduced plasma inflammatory biomarkers and a lower risk of CVD, T2D and other chronic diseases. In respect to nutrients, excessive intake of carbohydrates, saturated fat, trans-fatty acids, and omega-6 polyunsaturated fatty acids (PUFA) may activate the innate immune system, leading to an excessive production of pro inflammatory cytokines associated with a reduced synthesis of anti-inflammatory cytokines. On the other hand, omega-3 PUFA, vitamin E and polyphenols could counter the effects of several inflammatory markers, decreasing, for example, the secretion of circulating and cellular factors involved in the atherosclerotic process.This review explains how healthy dietary patterns, foods and nutrients can reduce chronic inflammatory processes related to CVD, T2D, obesity or cancer and therefore be a good tool to prevent the development of these disorders.

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Dietary factors associated with subclinical inflammation among girls

Abstract: Subclinical inflammation is detectable with increasing BMI and also WHtR. Measures of adiposity (BMI and WHtR) are significant predictors of adiponectin, leptin and hs-CRP. Dietary patterns per se have a small role in affecting inflammatory markers among adolescents.

Cited by 39 publications

References 50 publications

The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

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