Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Kim, Minkyeong; Park, Kyong

doi:10.3390/nu10121963

Cited by 66 publications

(55 citation statements)

References 44 publications

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“…Previous study has shown that CRC risk was higher in high fat-intake groups than that in low fat-intake groups (20). However, a recent systematic review and meta-analysis reported that dietary fats and fatty acids had no effects on the risk of CRC based on a systematic analysis of publications found on PubMed, Web of Science, and the Cochrane library for articles related to dietary fat and the risk of CRC (21). Independent of exercise and obesity, prolonged sedentary TV watching time, a surrogate for a more inactive lifestyle, was found associated with increased risk of young-onset CRC (yCRC), particularly of rectal cancer (22).…”

Section: Discussionmentioning

confidence: 99%

Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017

Yin¹,

Bai²,

Zhang³

et al. 2019

Chinese Journal of Cancer Research

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Objective Our goal is to analyze the trend of colorectal cancer (CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease (GBD). Methods The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation (IHME) GBD 2017, based on the rates of death, incidence and prevalence. Results The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In 1990, CRC ranked 21st in all causes of death in China compared to its 11th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017. The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in 2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in 141.6%, 209.8% and 189.0% for the studied three age groups (15−49, 50−69 and 70+ years old), respectively. The death rate increased in the age groups of 50−69 and 70+ years in both genders (8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15−49 years old (−10.8%). Conclusions China experienced a stunning increase in terms of incidence and prevalence rate of CRC from 1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices.

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Section: Discussionmentioning

confidence: 99%

Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017

Yin¹,

Bai²,

Zhang³

et al. 2019

Chinese Journal of Cancer Research

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“…Similarly, a positive association between TFA and SFA and localized CRC (Dukes A or B) was found among women in the SCHS 8 . A recent meta‐analysis conducted in 2018, which included 18 prospective cohorts, however, reported no effect of TFA, SFA, MUFA, and a combination of total polyunsaturated fatty acids (PUFA), n‐3 PUFA and n‐6 PUFA on the risk of CRC, overall and in subgroup analyses by sex or continent 9 . Among specific types of PUFA, the potentially preventive effects of total n‐3 PUFA and marine‐derived n‐3 PUFA on CRC risk have been investigated in several epidemiological studies 10 .…”

Section: Introductionmentioning

confidence: 99%

“…8 A recent meta-analysis conducted in 2018, which included 18 prospective cohorts, however, reported no effect of TFA, SFA, MUFA, and a combination of total polyunsaturated fatty acids (PUFA), n-3 PUFA and n-6 PUFA on the risk of CRC, overall and in subgroup analyses by sex or continent. 9 Among specific types of PUFA, the potentially preventive effects of total n-3 PUFA and marine-derived n-3 PUFA on CRC risk have been investigated in several epidemiological studies. 10 A 2015 meta-analysis of 14 prospective cohorts with 8775 cancer cases revealed no association between total n-3 PUFA and marine-derived n-3 PUFA intake and risk of CRC, but a significantly positive association was found between marine-derived n-3 PUFA intake and risk of CRC among Asian men.…”

mentioning

confidence: 99%

Dietary fatty acids and colorectal cancer risk in men: A report from the Shanghai Men's Health Study and a meta‐analysis

Nguyen

et al. 2020

Intl Journal of Cancer

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Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor-promoting effects. Whether dietary fatty acids are associated with colorectal cancer (CRC) in humans remains inconclusive. We investigated associations between dietary fatty acids and risk of CRC among 59 986 men who participated in the Shanghai Men's Health Study (SMHS), an ongoing population-based prospective cohort study. We identified 876 incident CRC cases in the SMHS during a mean follow-up of 9.8 years. Associations between dietary fatty acid intake and CRC risk were evaluated by Cox proportional hazard regression analyses. Consumption of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) was not significantly associated with CRC risk. Multivariate hazard ratios (HRs) and respective 95% confidence intervals (CIs) for Quartile 4 vs Quartile 1 were 0.92 (0.74-1.14; P trend = 0.47) for SFA, 0.95 (0.79-1.16; P trend = 0.74) for MUFA and 1.18 (0.95-1.46; P trend = 0.21) for PUFA. No significant associations were found for total n-6 PUFA or total n-3 PUFA. Additionally, we performed a metaanalysis to summarize results from the present study and 28 reports from 26 additional cohorts, which supported the overall null association between dietary fatty acid intake and CRC risk among men. Docosahexanoic acid and eicosapentaenoic acid were associated with 11% to 12% reduced risk, and linoleic acid a 19% increased risk, of CRC in the meta-analysis of combined sexes. In conclusion, this populationbased prospective study and meta-analysis of cohort studies found little evidence that dietary fatty acid intake was associated with risk of CRC in men.

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“…However, the risk may also be determined through indirect mechanisms such as obesity. Colorectal and lung cancers are the most frequently diagnosed neoplasia attributable to diet [35].…”

Section: Latency Period Between Exposure To Transition Diet and Cancementioning

confidence: 99%

Nutrition Transition and Cancer

et al. 2020

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Urbanization, population aging, and climatic changes have mostly contributed to nutrition transition and, consequently, to effects of food habits on the epidemic of chronic non-communicable diseases (NCDs), especially cancer. Climatic changes are negatively affecting crop production, particularly biodiversity, leading to reduced food choices and, consequently, nutritional value and the protection conferred from consumption of a variety of nutrients essential in a healthy diet. This brief review analyzes the possible link between rapid demographic changes, climatic and environmental crises, and the current food system as possible factors contributing to the role of nutrition transition in the onset of cancer.

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Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Cited by 66 publications

References 44 publications

Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017

Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017

Dietary fatty acids and colorectal cancer risk in men: A report from the Shanghai Men's Health Study and a meta‐analysis

Nutrition Transition and Cancer

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