Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases

Dam, Rob M. van; Naidoo, Nasheen; Landberg, Rikard

doi:10.1097/mol.0b013e32835bcdff

Cited by 203 publications

(109 citation statements)

References 43 publications

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“…Treatment of diabetic animals with sodium selenite significantly inhibited increasing of serum and kidney lipid peroxidation in comparison with the untreated diabetic animals. Previous studies showed that using natural antioxidants supplements such as vitamin E (32), α-lipoic acid (33), flavonoids (34), oleanolic acid (35), selenium (36), vanadium, α-carotene, zinc, vitamin C (37, 38), aminoguanidine (39), lycopene (40) and natural phenolic compounds have protective effects on lipid peroxidation in diabetics and chronic disease (41). Several reports showed that selenium has neuroprotective effect and in cerebral ischemia and improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease (42,43).…”

Section: Discussionmentioning

confidence: 99%

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Ahmadvand

Khosrowbeygi

2015

Zahedan J Res Med Sci

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Background: Diabetes-related dysfunctions are the major causes of mortality and morbidity for diabetic patients. Objectives: Selenium is a potent antioxidant. In the present study, we examined antioxidative activities of sodium selenite and possible protective effect of it on serum, liver and kidney lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats. Materials and Methods: In this experimental study 40 Sprage Dawley male rats were divided into 4 groups randomly; group I as control, group II as sham treated with sodium selenite (1 mg/kg i.p. daily), group III as diabetic untreated, and group IV as diabetic treated with sodium selenite (1 mg/kg i.p. daily) after induce diabetes, respectively. Diabetes was induced in the 3rd and 4th groups by alloxan injection (s.c.). After 8 weeks, animals were anaesthetized, liver and kidney were then removed immediately and used fresh or kept frozen until analysis. Blood samples were also collected before killing of the rats to measure the lipid peroxidation and glutathione level. Results: Liver and kidney content of lipid peroxidation decreased in diabetic treated group compared with untreated group. Kidney content of glutathione significantly increased in diabetic treated group compared with untreated group. Serum level of glutathione and liver content of it slightly increased in diabetic treated group compared with untreated group. Conclusions: This study showed that sodium selenite might be a potent antioxidant and exert beneficial effects on the lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Ahmadvand

Khosrowbeygi

2015

Zahedan J Res Med Sci

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“…However, the epidemiologic evidence on the reduction in the chronic disease risk is still limited and usually inconsistent [4,5]. The strongest evidence of their health-protective effects is for cardiovascular diseases [6] and type 2 diabetes [7].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Global Flavonoid Intake and its Food Sources

Escobar‐Cévoli¹,

Castro‐Espín²,

Béraud³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Dietary patterns and food availability differ greatly between regions and countries around the world. As a result, there is a large variability in the intake of total flavonoids and flavonoid subclasses, and subsequently in their major food sources. However, we need to be aware of certain methodological issues when we compare studies on flavonoid intake.In order to evaluate the intake of flavonoids, the different potential dietary assessment methodologies (dietary questionnaires and biomarkers) will be presented. Advantages and limitations of using of the two main food composition databases on flavonoids (US Department of Agriculture and Phenol-Explorer databases) will be discussed. The intake of total flavonoid and flavonoid subclasses in the various studies around the world will be comprehensively reviewed. The major food sources of flavonoids by region/country will be described. The main determinants of the intake of flavonoids will be explained as well.Calculating the intake of flavonoids is the first step before estimating their potential protective effects against chronic diseases and is an essential step for developing future dietary guidelines on flavonoids.

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“…[1][2][3][4][5] . Among different polyphenols, flavonoids are most important and are produced as plants secondary metabolites 6 .…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Flavonoid Compound Extracted Cardanthera Difformis Druce and Study of Its Antibacterial and Antioxidant Activities in Vitro

De¹,

Das²,

Mandal³

2017

Int. Res. J. Pharm.

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AB STR ACTHuman beings have been utilizing plants for basic preventive and curative health care since time immemorial. Medicinal plants have been used to treat illness and disease for thousands of years. Even now they are economically important, being used in the pharmaceutical, cosmetic, perfumery, and food industries. Screening of medicinal plants for antimicrobial activities and phytochemicals is important for finding potential new compounds for therapeutic use. Humans are now struggling for their existence against different oxidative stress related diseases. Different meta-analysis suggests that poly-phenols, especially flavonoids, may play best protective role against this epidemiology. In this paper, an attempt has been made to present the results of the experimental studies carried out to characterize a flavonoid compound that has been isolated and primarily identified from a plant extract of Cardanthera difformis Druce. The compound has similar physiochemical properties like quercetin. Antibacterial activity of extracted flavonoid has been carried out against various types of bacterial human pathogens. The result shows that the extract of Cardanthera difformis has a good anti-bacterial activity against Salmonella typhi. It has been found that this anti-bacterial flavonoid compound is good anti-oxidant compound and the anti-oxidant potentiality of the same has been quantified by DPPH-spectrophotometric assay.

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Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases

Cited by 203 publications

References 43 publications

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

An Overview of Global Flavonoid Intake and its Food Sources

Isolation and Characterization of Flavonoid Compound Extracted Cardanthera Difformis Druce and Study of Its Antibacterial and Antioxidant Activities in Vitro

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