Dietary flaxseed protects against ventricular arrhythmias and left ventricular dilation after a myocardial infarction

Parikh, Mihir; Raj, Pema; Austria, J. Alejandro; Yu, Liping; Garg, Bhavana; Netticadan, Thomas; Pierce, Grant N.

doi:10.1016/j.jnutbio.2019.06.004

Cited by 36 publications

(40 citation statements)

References 40 publications

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“…The macronutrient composition of the experimental diets has been reported previously [ 22 ]. The fatty acid profile of the diets is presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Total fatty acids were extracted from the diet samples and derivatized as previously described [ 22 ]. The fatty acid methyl esters were separated on a DB225MS column (30 m × 0.25 mm diameter and 0.25 μm film thickness; Agilent Technologies Canada Inc., Mississauga, Ontario) using a Varian 450 GC with FID.…”

Section: Methodsmentioning

confidence: 99%

“…Dietary flaxseed recently demonstrated several positive effects in a coronary artery ligation induced model of MI in rats. Flaxseed supplementation reduced the incidence of ventricular arrhythmias as well as prevented an excessive increase in infarct size, myocardial fibrosis, inflammation, and left ventricular dilation [ 22 ]. However, the mechanism responsible for this cardioprotective effect of flaxseed was unclear.…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

et al. 2020

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MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). Dietary flaxseed has demonstrated a protective effect against an MI. The present study was carried out to test the hypothesis that dietary flaxseed supplementation before and after an MI regulates the expression of above-mentioned miRNAs to produce its cardioprotective effect. Animals were randomized after inducing MI by coronary artery ligation into: (a) sham MI with normal chow, (b) MI with normal chow, and (c–e) MI supplemented with either 10% milled flaxseed, or 4.4% flax oil enriched in alpha-linolenic acid (ALA), or 0.44% flax lignan secoisolariciresinol diglucoside. The feeding protocol consisted of 2 weeks before and 8 weeks after the surgery. Dietary flax oil supplementation selectively upregulated the cardiac expression of miR-133a, miR-135a, and miR-29b. The levels of collagen I expression were reduced in the flax oil group. We conclude that miR-133a, miR-135a, and miR-29b are sensitive to dietary flax oil, likely due to its rich ALA content. The cardioprotective effect of flaxseed in an MI could be due to modulation of these miRNAs.

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“…The macronutrient composition of the experimental diets has been reported previously [ 22 ]. The fatty acid profile of the diets is presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

et al. 2020

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“…Studies have confirmed that SDG suppresses dextran sulfate sodium salt-induced colitis [11], serves as an anti-inflammatory and barrier-protective agent in neuroinflammation [12], and exerts antihypercholesterolemic [13] and also angiogenesis and cardioprotection against ischemia-reperfusion injury [14]. In addition, SDG are effective in lowering blood pressure in individuals with hypertension and metabolic syndrome [15] and exert prevention and treatment of arrhythmias and ventricular remodeling postmyocardial infarction [16]. All these studies confirm the role of SDG in inflammation and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 91%

Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/IκB/NF-κB Pathway on Human Umbilical Vein Endothelial Cells

Zhang

Cheng

Wang

et al. 2020

Mediators of Inflammation

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Inflammation is a key regulator in the progression of atherosclerosis (AS) which extremely affects people’s health. Secoisolariciresinol diglucoside (SDG), a plant lignan, is relevant to angiogenesis and cardioprotection against ischemia-reperfusion injury and improves vascular disorders. However, the effect of SDG on cardiovascular disorder is not clear. In the present study, we aimed to investigate the effects of SDG on lipopolysaccharide- (LPS-) stimulated Human Umbilical Vein Endothelial Cells (HUVECs) and elucidate the underlying mechanism. The LPS-stimulated HUVEC cellular model was established. The cell viability, the cell tube formation activity, the nitric oxide (NO) release, the levels of inflammatory cytokine interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), the activation of nuclear factor kappa-B (NF-κB) pathway, and the expression of protein kinase B (Akt) were determined using Cell Counting Kit-8, cell tube-formation assay, western blotting, and enzyme-linked immunosorbent assay. Our results revealed that SDG reduces the angiogenic capacity of HUVECs and inhibited LPS-mediated HUVEC injury and apoptosis. In addition, SDG increased NO release and decreased the levels of IL-1β, IL-6, and TNF-α in LPS-treated HUVECs. Meanwhile, SDG inhibited the NF-κB pathway and downregulated Akt expression in LPS-induced HUVECs. Our results indicated that SDG relieves LPS-mediated HUVEC injury by inhibiting the NF-κB pathway which is partly dependent on the disruption of Akt activation. Therefore, SDG exerts its cytoprotective effects in the context of LPS-treated HUVECs via regulation of the Akt/IκB/NF-κB pathway and may be a potential treatment drug for cardiovascular disease.

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“…These essential acids raise the immunity, strengthen walls of blood vessels, increasing their elasticity, so they are used for treating and preventing atherosclerosis and intestinal diseases. Experimental studies on rats proved that α-linolenic acid of flax seeds has the important influence in treating and preventing hearth arrhythmias [16].…”

Section: Introductionmentioning

confidence: 99%

Study of the Influence of Buckwheat Flour and Flax Seeds on Consumption Properties of Long-Stored Bakery Products

Bondarenko

Mykhonik

Bilyk

et al. 2019

EUREKA: Life Sciences

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Rusk and ring-shaped bakery products relate to the group of long-stored ones. For today it is urgent to use ingredients that give products functional properties in food technologies. The important source of food fibers, full-value protein, unsaturated fatty acids, mineral substances and vitamins are grain and oil-bearing crops. Buckwheat and flax seeds are separated among them due to the valuable chemical composition and positive effect on the human organism. The aim of the work was to establish the influence of buckwheat flour and flax seeds on the technological process course and quality of long-stored bakery products. Buckwheat flour of green and dark buckwheat of TM “Organic-Eco-Product” (Ukraine) is used in the rusk technology. For producing ring-shaped products (ring-shaped crackers), gold flax seeds were used. Research results testify that good quality parameters of bread for producing rusks from it, were achieved at dosing green buckwheat seeds as 20 % and dark ones as 15 % instead of the flour mass. It has been established, that rusks with adding green buckwheat flour have quality parameters, corresponding to requirements of normative documents. It has been proven, that it is not expedient to use dark buckwheat flour in the rusk technology, because ready products have the increased water share and soaking index. It is connected with the influence of the operation of hydrothermal processing of grains that dark buckwheat flour is produced of, its high water-absorbing and water-retaining capacities. For the technology of ring-shaped crackers, enriched with flax seeds, it is recommended to dose flax seeds as 15 % of the flour mass. At such dosage bakery products got the highest number of points by the complex quality parameter and corresponded to requirements of normative documents.

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Dietary flaxseed protects against ventricular arrhythmias and left ventricular dilation after a myocardial infarction

Cited by 36 publications

References 40 publications

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/IκB/NF-κB Pathway on Human Umbilical Vein Endothelial Cells

Study of the Influence of Buckwheat Flour and Flax Seeds on Consumption Properties of Long-Stored Bakery Products

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