Dietary functional flavonoids as natural hepatoprotective agents against acute liver injury from hop (Humulus lupulus L.)

Zhou, Di; Wang, Cungang; Li, Xuezheng; Zhao, Yanrong; Jing, Jing; Ma, Yueping; Li, Jiayuan; Wei, Xiuyan; Li, Ning

doi:10.1016/j.jff.2018.04.042

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Preliminary phytochemical studies were done to identifying phytochemical constituents present in the different extract (Harbone, 2005). It shows phytoconstituents like flavonoid, phenolic, constituents are present in the ethanolic extract of , which are D.turbinatus known to be an antioxidant and hepatoprotective (Zhou, et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

Biswas¹,

Nirmala²,

Anjaneyulu³

et al. 2019

Asian J Pharm Pharmacol

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Objective: Dipterocarpus turbinatus is a large woody plant widely grown in Northeastern state, Tripura. Ethanol extract of leaves was evaluated for its antioxidant and hepatoprotective activity. D. turbinatusMaterials and Methods: The preliminary phytochemical study was carried out to find out the presence of various phytoconstituents in different extracts obtained by cold maceration. Antioxidant activity was done by Nitric oxide scavenging and DPPH* scavenging. Paracetamol (3gm/kg) was used to induce hepatotoxicity in rats and 200mg/kg & 400mg/kg of ethanol extract of leaves of (EEDT) was used for the study, while silymarin (50mg/kg) was used as a standard. D. turbinatus Blood was collected by retro-orbital puncture and various biochemical parameters were determined by photometric analysis.: Ethanolic extract showed different bioactive constituents like flavonoid, phenolic, alkaloid, tannin. ResultsPlant extract was exhibited antioxidant properties. Tested extracts showed a significant reduction in the elevated level of various biochemical parameters like SGOT, SGPT, ALP, total bilirubin & increase the level of protein level with the dose-dependent manner. Histopathological studies of the liver of the tested animal showed there is an improvement in the architecture of the hepatic cell with plant extract treatments.The results suggest that ethanolic extract Conclusion: of leaves in different dose shows significant hepatoprotective activity against paracetamol-induced D.turbinatus hepatotoxicity in rats.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

Biswas¹,

Nirmala²,

Anjaneyulu³

et al. 2019

Asian J Pharm Pharmacol

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“…Hop flavonoids could be a potential functional food to treat acute liver injury. For example, the cotreatment of male Kunming mice with 10 effective hop flavonoids extracted with 95% ethanol from dried flowers and including chalcones and dihydroflavones, at a dose of 25, 50, and 100 mg/kg for 7 days, markedly ameliorated the pathological hepatic lesions induced by CCl 4 and restored catalase, glutathione peroxidase, and superoxide dismutase activities to values similar to those of normal or bifendate-cotreated (300 mg/kg) groups …”

Section: Identification Of Nutritional Factors In H Lupulusmentioning

confidence: 99%

“…The female inflorescences of H. lupulus harvested in XinJiang (China) contain at least 33 flavonoids, as determined by analysis using high-performance liquid chromatography coupled with mass spectrometry. These 33 flavonoids were identified as xanthohumol, isoxanthohumol, homoisoxanthohumol, 5-methoxy-isoxanthohumol J, 1″,2″-dihydroxanthohumol C, 1-[2-(β- d -glucopyranosyloxy)-4,6-dihydroxyphenyl]-2-methyl-1-butanone, kaempferol 3-O-α- l -rhamnopyranoside, 2′,4′,6′,4-tetrahydroxy-3′- C -prenylchalcone, 6″,6″-dimethylpyrano (2″,3″: 3′,4′)-2′,4-dihydroxy-6′-methoxychalcone, 1-[2-(β- d -glucopyranosyloxy)-4,6-dihydroxyphenyl]-2-methyl-1-butanone, and so on . Seven flavonoids, including xanthohumol, isoxanthohumol, xanthohumol B, xanthohumol C, flavokawain C, 6-prenylnaringenin and 4′- O -methylxanthohumol, isolated from a methanol extract of Humulus, exhibited effective inhibitory effects on the monophenolase (IC 50 = 15.4–77.4 μM) and diphenolase (IC 50 = 31.1–157.4 μM) activities of mushroom tyrosinase, which can produce excessive amounts of melanin, causing hyperpigmentation of the skin and contributing to the neurodegeneration associated with Parkinson’s disease, particularly in males …”

Section: Identification Of Nutritional Factors In H Lupulusmentioning

confidence: 99%

Role of Characteristic Components of Humulus lupulus in Promoting Human Health

Lin

Xiang

Chen

et al. 2019

J. Agric. Food Chem.

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Over the next 50 years, the prevention and control of chronic diseases, such as obesity, cardiovascular disease, Alzheimer's disease, and many cancers, will be one of the most critical challenges in human health. Plant biochemistry and phytonutrient supplements are a promising complementary therapy for the management of chronic disease. Among them, Humulus lupulus has attracted special attention throughout the world because it contains numerous dietary phytochemicals that not only contribute to the aroma and flavor of beer but may also be used for medicinal purposes, as its properties include antiseptic, (an)aphrodisiac, anticancer, antiplatelet, antibacterial, antidiuretic, anti-inflammatory, sedative, hypnotic, and stomachic properties. This review sought to identify and understand the risk factors for chronic disease with a focus on two types of phytochemicals, bitter acids and xanthohumol. The goal was to understand how their metabolites promote human health and reduce the risk of chronic disease.

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“…Anti-inflammatory [71,72], antioxidant activities; hepatoprotective [73] and osteoprotective effects [74].…”

Section: Female Inflorescences Of Humulus Lupulus (Hops)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third of the tested extracts showed in vitro inhibitory effects comparable to the positive control oxozeaenol, an inhibitor of TAK1. Among them, the extract derived from the roots and rhizomes of Peucedanum ostruthium (i.e., Radix Imperatoriae), also known as masterwort, showed a pronounced and dose-dependent inhibitory effect. Reporter gene analysis demonstrated that inhibition takes place on the transcriptional level and involves the transcription factor NF-κB. A more detailed analysis revealed that the P. ostruthium extract (PO) affected the phosphorylation, degradation, and resynthesis of IκBα, the activation of IKKs, and the nuclear translocation of the NF-κB subunit RelA. Strikingly, early effects on this pathway were less affected as compared to later ones, suggesting that PO may act on mechanism(s) that are downstream of nuclear translocation. As the majority of cognate NF-κB inhibitors affect upstream events such as IKK2, these findings could indicate the existence of targetable signaling events at later stages of NF-κB activation.

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Dietary functional flavonoids as natural hepatoprotective agents against acute liver injury from hop (Humulus lupulus L.)

Cited by 11 publications

References 29 publications

Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

Role of Characteristic Components of Humulus lupulus in Promoting Human Health

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

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