Dietary Yucca schidigera supplementation reduces arsenic-induced oxidative stress in Swiss albino mice

Abstract

The aim of this study was to clarify the effects of dietary supplementation with Yucca schidigera (Ys) on lipid peroxidation (LPO), antioxidant activity, some biochemical parameters and histopathological changes in arsenic-exposed mice. Forty Swiss albino male mice were divided into five equal groups. Group I (control group) was given normal diet and tap water for 28 days. Group II (arsenic group) was given normal diet and 100 mg/L arsenic along with drinking water for 28 days. Groups III-V were given three different doses of Ys (50, 100 and 200 mg/kg) in supplemented diet and arsenic (100 mg/L) along with drinking water throughout the entire period of 28 days. The arsenic significantly increased serum biochemical parameters and malondialdehyde levels in blood and tissue. However, arsenic significantly decreased tissue glutathione concentration, erythrocyte superoxide dismutase and catalase activities. In contrast, dietary supplementation of Ys, in a dose-dependent manner, resulted in reversal of arsenic-induced oxidative stress, LPO and activities of antioxidant enzymes. Moreover, Ys also exhibited protective action against the arsenic-induced focal gliosis and hyperemi in brain, necrosis and degeneration in liver, degeneration and dilatation in Bowman's capsule of kidney and hyaline degeneration in heart tissue of mice. Consequently, our results demonstrate that Ys especially high-dose supplementation in diet decreases arsenic-induced oxidative stress and enhances the antioxidant defence mechanism and regenerate of tissues in Swiss albino mice.

Ameliorative effect of polydatin on oxidative stress-mediated testicular damage by chronic arsenic exposure in rats

“…Many researchers have demonstrated that in vivo arsenic exposure affected the sperm function (Sarkar et al, 2003;Momeni & Eskandari, 2012). Arsenic causes oxidative stress on male reproductive system (Tandon et al, 2012;Ince et al, 2013), as well as increases levels of MDA, decreases the GSH levels and activities of antioxidant enzymes such as SOD and CAT (Chang et al, 2007;Manna et al, 2008;Ince et al, 2013). The enhanced production of tissue LPO observed in this study agrees with the results of other studies.…”

“…The control group received a standard diet and tap water, arsenic (100 mg l À1 , approximately 1/50 of oral LD 50 ) was given via drinking water (Glattre et al, 1995;Ince et al, 2013) to experimental groups except control group, and PD was orally given to the other groups at dose of 50, 100 and 200 mg kg À1 during 60 days. At the end of the experiment, animals were anaesthetised with light ether and then sacrificed.…”

“…Several studies have shown that antioxidant nutrients protect cells against the deleterious effects of environmental agents (El-Neweshy et al, 2013;Ince et al, 2013). Polygonum cuspidatum root (RPC) is a widely used traditional medicine in Asia, which has been shown to exhibit antibacterial (Shan et al, 2008), antioxidant (Pan et al, 2007) and anti-angiogenesis (Wang et al, 2004) activities.…”

The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

“…In the study, arsenic increased MDA levels of tissues and caused LPO in rats. The findings are similar to many other studies . These studies show that arsenic has an important oxidant effect and increases the formation of free radicals and decreases the efficiency of antioxidants, thus significantly increasing MDA levels .…”

Effects of Yucca schidigera extract on growth performance and antioxidative function of small intestine in broilers

“…Glutathion peroxidase (GPx) and catalase (CAT) activities were increased with YSE supplementation in rabbits (Ashour, Alagawany, Reda, & Abd El‐Hac, ). Dietary supplementation of YSE, in a dose‐dependent manner, ameliorated arsenic‐induced oxidative stress, lipid peroxidation and increased activities of antioxidant enzymes in mice (Ince, Kucukkurt, Turkmen, Demirel, & Sever, ). YSE can also compensate the toxic effects of lead‐induced oxidative stress in quails (Alagawany et al, ; Farag et al, ).…”