Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

Abdel‐Wahhab, Mosaad A.; Joubert, O.; El‐Nekeety, Aziza A.; Sharaf, Hafiza A; Abu-Salem, Ferial M.; Rihn, Bertrand

doi:10.4103/2394-5079.168078

Cited by 11 publications

(8 citation statements)

References 69 publications

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“…Similarly, groups G11, G12, and G13 showed a significant reduction in serum levels of creatinine, urea, cholesterol, and triglyceride comparing with high AFS control (G4). These observations are agreed by that of Ayoub et al, (2011);Abdel-Wahhab, et al, (2016) and Sobhy, et al, (2016) that used Jojoba oil and Nigella cake protein as feed supplement. Urea is formed in the liver and represents the principal end product of protein catabolism.…”

Section: Resultssupporting

confidence: 92%

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Abdelrahman

Ali

Abo-hagger

et al. 2017

Journal of Agricultural Chemistry and Biotechnology

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An experiment was conducted to determine the efficiency of banana peel to reduce the toxic effect of aflatoxins (AFS) in male albino rats. Seventy eight male albino rats were assigned to 13 experimental diets. The first one served as control received basal diet only, the second served as control DMSO (basal diet and 5ml DMSO /kg B.W.) daily, but the third and fourth one were received 1mg and 2mg AFs/ml respectively. The three following groups were received basal diet only supplemented with banana peel in percentage of 1,2 and 3%,then three groups received basal diet and orally (1mg AFS suspended in 5ml DMSO /kg B.W.) low dose of aflatoxins with the same levels of banana peel. The last three groups received basal diet and orally (2mg AFS suspended in 5ml DMSO /kg B.W.) high dose of aflatoxins with the same levels of banana peel .The duration of this experiment was 6 weeks. Results showed that, albino rats received 38mg and 76mg/kg aflatoxins revealed a significant elevation in the serum levels of AST, ALT, ALP, creatinine, urea, cholesterol and triglyceride, while decrease in total protein (TP) and albumin. Results of hematological parameters showed decrease in red blood cells (RBCs), hemoglobin (HB), packed cell volume (PCV), mean Corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) and platelets while increase in total leucocyte count (TLC).Body weights and organ weights were determined to study its changes. The treatments with banana peel can play a practical role in detoxification of aflatoxins in albino rats. G3Received orally low dose of AF S (1mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G4 Received orally high dose of AF S (2mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G5 Received basal diet supplemented with banana peel at level 1% G6 Received basal diet supplemented with banana peel at level 2% G7 Received basal diet supplemented with banana peel at level 3% G8 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G9 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G10 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel G11 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G12 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G13 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel

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Section: Resultssupporting

confidence: 92%

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Abdelrahman

Ali

Abo-hagger

et al. 2017

Journal of Agricultural Chemistry and Biotechnology

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“…The increase of ALT level by HFHF diet was reversed by ND and jojoba meal while staying on a diet without high-fat high-fructose or on diet mixed with HFHF diet. Our results were in agreement with Abdel-Wahhab et al [43]. These authors showed a decrease in the ALT level by ethanolic extract.…”

Section: Discussionsupporting

confidence: 94%

Anorexic and metabolic effect of jojoba: potential treatment against metabolic syndrome and hepatic complications

Belhadj

Dal

Fakhreddine³

et al. 2020

Nutr Metab (Lond)

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Background: Evaluation of the action of various traditional plants to treat metabolic syndrome are strongly studied. In our study, we investigated the effect of the Tunisian jojoba seed on a metabolic syndrome induced in rat by the High Fat diet and High Fructose (HFHF) and its renal and hepatic complications. Methods: The rats were fed with HFHF or Normal Diet (ND) for a period of 8 weeks. After that, a switch from HFHF to ND or Normal Diet Jojoba (NDJ),(jojoba diet approach) or High Fat and High Fructose and Jojoba diet (HFHFJ) (nutraceutical approach) has been done. Metabolic disorder was evaluated by measuring the fasting body weight, glycemia and C-peptide and leptin. Oxidative stress parameters like ThioBarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Capacity (TAOC) were analyzed in the plasma and renal and hepatic function were determined by the measure of creatinine and alanine transferase (ALT) respectively. Histological analysis was performed on the liver, kidney and pancreas. Results: HFHF diet exhibited characteristics of metabolic syndrome presented by insulin resistance, hyperinsulinemia, hyperleptinemia, fat mass with hepatic steatosis and renal disorder. HFHF diet was associated with oxidative stress (OS) presented by an increase in TBARS and a decrease in TAOC. Adding jojoba seeds to HFHF rat group diet induced a decrease in body weight, fat mass (58 and 41%), insulin resistance (59 and 56%), oxidative stress (60 and 41%), liver steatosis (from a score = 3 to a score = 0) and renal complications (25 and 42%). This effect was emphasized with diet approach. Conclusion: The results demonstrated the beneficial effect of jojoba against metabolic syndrome and oxidative stress, suggesting that jojoba could be used in the prevention and treatment of metabolic syndrome.

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“…Feeding curcumin to afla-intoxicated mice resulted in significant improvement in levels of TAC and SOD. Our results were in accordance to those of Choi et al, (2011) and Abdel-Wahhab et al (2016). It was clear from the results that AFs have adverse effects on mice health via their ability to induce oxidative stress that furthermore led to the promotion of lipid peroxidation.…”

Section: Discussionsupporting

confidence: 91%

Effect of Dietary Curcumin on Heptorenal Alfla-Toxicosis in Mice

Abdelrazek

Zeidan

Soliman

et al. 2018

Egyptian Academic Journal of Biological Sciences, F. Toxicology

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The journal of Toxicology and pest control is one of the series issued twice by the Egyptian Academic Journal of Biological Sciences, and is devoted to publication of original papers related to the interaction between insects and their environment. The goal of the journal is to advance the scientific understanding of mechanisms of toxicity. Emphasis will be placed on toxic effects observed at relevant exposures, which have direct impact on safety evaluation and risk assessment. The journal therefore welcomes papers on biology ranging from molecular and cell biology, biochemistry and physiology to ecology and environment, also systematics, microbiology, toxicology, hydrobiology, radiobiology and biotechnology. www.eajbs.eg.net

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Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

Cited by 11 publications

References 69 publications

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Anorexic and metabolic effect of jojoba: potential treatment against metabolic syndrome and hepatic complications

Effect of Dietary Curcumin on Heptorenal Alfla-Toxicosis in Mice

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