Dietary intake of mixture coarse cereals prevents obesity by altering the gut microbiota in high-fat diet fed mice

Ji, Yang; Ma, Ning; Zhang, Junmiao; Wang, Hetong; Tao, Tianyi; Pei, Fei; Hu, Qiuhui

doi:10.1016/j.fct.2020.111901

Cited by 38 publications

(24 citation statements)

References 46 publications

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“…As previously reported, HFD can promote obesity by altering the expression of lipid-related genes in the liver ( 56 ). Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor superfamily ( 57 ).…”

Section: Discussionsupporting

confidence: 54%

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Wen

et al. 2022

Front. Nutr.

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Moringa oleifera is a commonly used plant with high nutritional and medicinal values. M. oleifera leaves are considered a new food resource in China. However, the biological activities of M. oleifera polysaccharides (MOP) in regulating gut microbiota and alleviating obesity remain obscure. In the present study, we prepared the MOP and evaluated its effects on obesity and gut microbiota in high-fat diet (HFD)-induced C57BL/6J mice. The experimental mice were supplemented with a normal chow diet (NCD group), a high-fat diet (HFD group), and HFD along with MOP at a different dose of 100, 200, and 400 mg/kg/d, respectively. Physiological, histological, biochemical parameters, genes related to lipid metabolism, and gut microbiota composition were compared among five experimental groups. The results showed that MOP supplementation effectively prevented weight gain and lipid accumulation induced by HFD, ameliorated blood lipid levels and insulin resistance, alleviated the secretion of pro-inflammatory cytokines, and regulated the expression of genes related to lipid metabolism and bile acid metabolism. In addition, MOP positively reshaped the gut microbiota composition, significantly increasing the abundance of Bacteroides, norank_f_Ruminococcaceae, and Oscillibacter, while decreasing the relative abundance of Blautia, Alistipes, and Tyzzerella, which are closely associated with obesity. These results demonstrated that MOP supplementation has a protective effect against HFD-induced obesity in mice, which was associated with reshaping the gut microbiota. To the best of our knowledge, this is the first report on the potential of MOP to prevent obesity and modulating gut microbiota, which suggests that MOP can be used as a potential prebiotic.

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Section: Discussionsupporting

confidence: 54%

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Wen

et al. 2022

Front. Nutr.

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“…Some studies reported the F/B value to have a positive correlation with obesity. 18,50 However, the F/B ratio is not a powerful indicator of microbial imbalance associated with obesity, and is closely related to the microbial composition of Firmicutes and Bacteroidetes. After treatment with GTP, the abundance of Firmicutes increased significantly, whereas that of Bacteroidetes decreased significantly in SPF mice (Fig.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the regulation of intestinal bacteriophages by green tea polyphenols and the flora diversity in SPF mice

et al. 2022

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“…In an experiment by Ji et al, dietary intake of a mixture of coarse cereals could prevent body weight gain and fat accumulation, improve blood glucose tolerance and serum lipids levels, and reduce systemic inflammation in HFD-fed mice. Moreover, the relative abundances of Lactobacillus and Bifidobacterium could be increased after supplementing with a mixture of coarse cereals, which might contribute to the anti-obesity activity [93].…”

Section: Effects On Obesitymentioning

confidence: 99%

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

Ren

Fan

Teng

et al. 2021

Foods

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In recent years, chronic diseases including obesity, diabetes, cancer, cardiovascular, and neurodegenerative disorders have been the leading causes of incapacity and death globally. Increasing evidence suggests that improvements of lifestyle habits and diet is the most commonly adopted strategy for the prevention of chronic disorders. Moreover, many dietary compounds have revealed health-promoting benefits beyond their nutritional effects. It is worth noting that diet plays an important role in shaping the intestinal microbiota. Coarse cereals constitute important sources of nutrients for the gut microbiota and contribute to a healthy gut microbiome. Furthermore, the gut microbiota converts coarse cereals into functional substances and mediates the interaction between the host and these components. In this study, we summarize the recent findings concerning functional components of cereal grains and their potential chemopreventive activity via modulating the gut microbiota.

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Dietary intake of mixture coarse cereals prevents obesity by altering the gut microbiota in high-fat diet fed mice

Cited by 38 publications

References 46 publications

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Correlation between the regulation of intestinal bacteriophages by green tea polyphenols and the flora diversity in SPF mice

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

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