Dietary intake of polyphenols and risk of colorectal cancer and adenoma<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mo>–</mml:mo></mml:math>A case-control study from Iran

Bahrami, Alireza; Jafari, Saeede; Rafiei, Pegah; Beigrezaei, Sara; Sadeghi, Amir; Hekmatdoost, Azita; Rashidkhani, Bahram; Hejazi, Ehsan

doi:10.1016/j.ctim.2019.04.011

Cited by 21 publications

(10 citation statements)

References 83 publications

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“…Eighteen of these articles were cohort studies (21, 24-27, 32, 33, 36, 40, 41, 47, 51, 55, 57, 59, 61, 62, 69), and 31 were case-control studies (22, 23, 28-31, 34, 35, 37-39, 42-46, 48-50, 52-54, 56-58, 60, 63-68). Sixteen articles were performed in Europe (22, 24, 29, 33, 37, 40, 42, 43, 45, 48-50, 52, 59-61), 15 articles were attributed to North America (21,23,26,28,30,32,35,36,38,41,44,54,56,57,68), 16 articles were Asian (25,27,31,34,46,47,51,53,58,(62)(63)(64)(65)(66)(67)69) and the remaining 2 articles were from Oceania (39,55). Depending on the study endpoints, 6 articles focused on pancreatic cancer (21,28,(41)(42)(43)(44), 23 articles focused on colorectal cancer (22, 24, 27, 29, 34-37, 40, 45, 46, 50, 51, 53-56, 58, 59, 61-64), 12 studies examined colon cancer (23, 24, 26, 27, 37, 51, 55-57, 59, 61, 62), 12 studies were perfo...…”

Section: Study Characteristicsmentioning

confidence: 99%

The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects

Zhao

Zhan

Wang

et al. 2022

Front. Public Health

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Background and ObjectivesDiets containing red or processed meat are associated with a growing risk of digestive system cancers. Whether a plant-based diet is protective against cancer needs a high level of statistical evidence.MethodsWe performed a meta-analysis of five English databases, including PubMed, Medline, Embase, Web of Science databases, and Scopus, on October 24, 2021 to identify published papers. Cohort studies or case-control studies that reported a relationship between plant-based diets and cancers of the digestive system were included. Summary effect-size estimates are expressed as Risk ratios (RRs) or Odds ratios (ORs) with 95% confidence intervals and were evaluated using random-effect models. The inconsistency index (I2) and τ2 (Tau2) index were used to quantify the magnitude of heterogeneity derived from the random-effects Mantel-Haenszel model.ResultsThe same results were found in cohort (adjusted RR = 0.82, 95% CI: 0.78–0.86, P < 0.001, I2 = 46.4%, Tau2 = 0.017) and case-control (adjusted OR = 0.70, 95% CI: 0.64–0.77, P < 0.001, I2 = 83.8%, Tau2 = 0.160) studies. The overall analysis concluded that plant-based diets played a protective role in the risk of digestive system neoplasms. Subgroup analyses demonstrated that the plant-based diets reduced the risk of cancers, especially pancreatic (adjusted RR = 0.71, 95% CI: 0.59–0.86, P < 0.001, I2 = 55.1%, Tau2 = 0.028), colorectal (adjusted RR = 0.76, 95% CI: 0.69–0.83, P < 0.001, I2 = 53.4%, Tau2 = 0.023), rectal (adjusted RR = 0.84, 95% CI: 0.78–0.91, P < 0.001, I2 = 1.6%, Tau2 = 0.005) and colon (adjusted RR = 0.88, 95% CI: 0.82–0.95, P < 0.001, I2 = 0.0%, Tau2 = 0.000) cancers, in cohort studies. The correlation between vegan and other plant-based diets was compared using Z-tests, and the results showed no difference.ConclusionsPlant-based diets were protective against cancers of the digestive system, with no significant differences between different types of cancer.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322276, Identifier: CRD42022322276.

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Section: Study Characteristicsmentioning

confidence: 99%

The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects

Zhao

Zhan

Wang

et al. 2022

Front. Public Health

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“…A recent population case-control study (n = 499) showed that a higher intake of total polyphenols, total flavonoids, total phenolic acids, anthocyanin, and flavanols was related to the decreased risk of CRC [96]. The biological effects for different native polyphenols have been discussed in several systematic papers (Table 1).…”

Section: Direct and Gut-microbiota-modulating Mechanisms Of Action Ofmentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications.

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“…It is possible that the association between isoflavones and BC risk is not established through dietary studies, but only through urine excretion measurements [ 35 ]. Most previous studies have focused on some specific classes of polyphenols and flavonoids, while the evaluation of other polyphenol subclasses has been less studied [ 36 37 38 ]. Previous studies have reported different levels of polyphenol and polyphenol subclasses consumption [ 39 40 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake of Polyphenols and the Risk of Breast Cancer: a Case-Control Study

et al. 2021

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Dietary intake of polyphenols and risk of colorectal cancer and adenoma–A case-control study from Iran

Cited by 21 publications

References 83 publications

The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects

The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Dietary Intake of Polyphenols and the Risk of Breast Cancer: a Case-Control Study

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