Dietary Iron and Colorectal Cancer Risk: A Review of Human Population Studies

Ashmore, Joseph H.; Rogers, Connie J.; Kelleher, Shannon L.; Lesko, Samuel M.; Hartman, Terryl J.

doi:10.1080/10408398.2012.749208

Cited by 31 publications

(23 citation statements)

References 59 publications

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“…High dietary iron intake or patients with iron overload have increased risk for CRC (Cross et al, 2010; Osborne et al, 2010). Patients with lower iron or in mouse models treated with low iron diet exhibit a decrease in CRC (Ashmore et al, 2015; Bastide et al, 2015; Nelson, 2001). The majority of previously described mouse genetic models of intestinal tumorigenesis mainly develop small intestinal adenoma (Johnson and Fleet, 2013).…”

Section: Discussionmentioning

confidence: 99%

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

et al. 2016

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Summary Dietary iron intake and systemic iron balance are implicated in colorectal cancer (CRC) development, but the means by which iron contributes to CRC are unclear. Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia inducible factor 2α-dependent transcription. Colon-specific Dmt1 disruption resulted in a tumor-selective inhibitory effect of proliferation in mouse colon tumor models. Proteomic and genomic analysis identified an iron-regulated signaling axis mediated by cyclin dependent kinase 1 (CDK1), JAK1 and STAT3 in CRC progression. A pharmacological inhibitor of DMT1 antagonized the ability of iron to promote tumor growth in a CRC mouse model and a patient-derived CRC enteroid orthotopic model. Our studies implicate a growth-promoting signaling network instigated by elevated intracellular iron levels in tumorigenesis, offering molecular insights into how a key dietary component may contribute to CRC.

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Section: Discussionmentioning

confidence: 99%

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

et al. 2016

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“…Although several studies have indeed shown a correlation between the incidence and mortality of cancer and systemic iron levels, as measured by transferrin saturation or serum ferritin, this correlation is generally not strong, has shown conflicting outcomes, and it is often confounded by the presence of other pathology88,89. There is, however, clear evidence that deregulated iron homeostasis on a local — that is, microenvironmental and/or cellular — level is associated with tumour progression, as illustrated by changes in expression of iron-related genes in cancer cells (Figure 4), the levels of which are inversely correlated with patient survival90–92.…”

Section: Iron and The Pathophysiology Of Diseasementioning

confidence: 99%

Targeting iron metabolism in drug discovery and delivery

Crielaard

Lammers

Rivella

2017

Nat Rev Drug Discov

290

205

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Iron fulfils a central role in many essential biochemical processes in human physiology, which makes proper processing of iron crucial. Although iron metabolism is subject to relatively strict physiological control, in recent years numerous disorders, such as cancer and neurodegenerative diseases, have been linked to deregulated iron homeostasis. Because of its involvement in the pathogenesis of these diseases, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents will likely have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are often available.

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“…Thus, haem iron content in red meat products, including processed products, was suggested as an important carcinogenic parameter contributing to the associations found in epidemiologic studies (Bastide et al 2016). An association between colorectal cancer risk and intake of iron, in particular haem iron, has been shown in several, but not all, epidemiologic studies (Ashmore et al 2016). The epidemiological studies on the carcinogenic effects of haem iron are conflicting.…”

Section: Haem Ironmentioning

confidence: 99%

Suggestion for a subdivision of processed meat products on the Danish market based on their content of carcinogenic compounds

et al. 2019

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Carcinogenic effects in humans are ascribed to processed meat by organisations such as International Agency for Research on Cancer, World Cancer Research Fund and American Institute for Cancer Research. However, the term 'processed meat' covers a heterogenic group of products whose content of potential hazards differ considerably. To improve estimates of associations between processed meat intake and cancer risk we investigated ways to divide processed meat into subgroups that more precisely reflects its carcinogenic characteristics. We collected ingredient lists and declarations of salt content for >1000 processed meat products on the Danish market and combined the information with knowledge related to processing parameters. Some compounds that could affect the products' carcinogenic characteristics, alone or in combination, were evaluated and compared for 12 types of processed meat products, and we suggest subgrouping of processed meat with similar level of carcinogenic potential, which could improve the understanding of the cancer risk associated with processed meat intake in scientific human studies.

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Dietary Iron and Colorectal Cancer Risk: A Review of Human Population Studies

Cited by 31 publications

References 59 publications

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

Targeting iron metabolism in drug discovery and delivery

Suggestion for a subdivision of processed meat products on the Danish market based on their content of carcinogenic compounds

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