Dietary Lycopene, Angiogenesis, and Prostate Cancer: A Prospective Study in the Prostate-Specific Antigen Era

Zu, Ke; Mucci, Lorelei A.; Rosner, Bernard; Clinton, Steven K.; Loda, Massimo; Stampfer, Meir J.; Giovannucci, Edward

doi:10.1093/jnci/djt430

Cited by 191 publications

(147 citation statements)

References 40 publications

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“…Lycopene, the predominant carotenoid found in tomatoes, has been widely investigated for its effects in PCa. Lycopene has been demonstrated to modulate growth factor signaling, cell-cycle programming, angiogenesis, and apoptosis in PCa cell lines [3][4][5][6][7][8][9]. Numerous epidemiology studies have examined the effects of lycopene and tomato products on PCa risk [2, 7,10].…”

Section: Introductionmentioning

confidence: 99%

Low-lycopene containing tomato powder diet does not protect against prostate cancer in TRAMP mice

2015

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Section: Introductionmentioning

confidence: 99%

Low-lycopene containing tomato powder diet does not protect against prostate cancer in TRAMP mice

2015

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“…Our results are consistent with studies that suggest dietary and circulating lycopene has stronger inverse associations with risk of lethal or aggressive diseases. 16,32 One plausible explanation is that low-grade tumors that progress slowly may not be sensitive to effects of lycopene, while high-grade tumors that progress rapidly are more susceptible to inhibition by lycopene. In addition, an average of 10 years of follow-up may not be long enough to observe an association for low-grade tumors, relatively few of which are fatal within 10 years.…”

Section: Discussionmentioning

confidence: 99%

Lycopene, tomato products and prostate cancer‐specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort

Wáng

Jacobs

Newton

et al. 2016

Intl Journal of Cancer

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While dietary lycopene and tomato products have been inversely associated with prostate cancer incidence, there is limited evidence for an association between consumption of lycopene and tomato products and prostate-cancer specific mortality (PCSM). We examined the associations of prediagnosis and postdiagnosis dietary lycopene and tomato product intake with PCSM in a large prospective cohort. This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study II Nutrition Cohort in 1992 or 1993 and June 2011. Prediagnosis dietary data, collected at baseline, were available for 8,898 men, of whom 526 died of prostate cancer through 2012. Postdiagnosis dietary data, collected on follow-up surveys in 1999 and/or 2003, were available for 5,643 men, of whom 363 died of prostate cancer through 2012. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for PCSM. Neither prediagnosis nor postdiagnosis dietary lycopene intake was associated with PCSM (fourth vs. first quartile HR 5 1.00, 95% CI 0.78-1.28; HR 5 1.22, 95% CI 0.91-1.64, respectively). Similarly, neither prediagnosis nor postdiagnosis consumption of tomato products was associated with PCSM. Among men with high-risk cancers (T3-T4 or Gleason score 8-10, or nodal involvement), consistently reporting lycopene intake median on both postdiagnosis surveys was associated with lower PCSM (HR 5 0.41, 95% CI 0.17-0.99, based on ten PCSM cases consistently median intake) compared to consistently reporting intake < median. Future studies are needed to confirm the potential inverse association of consistently high lycopene intake with PCSM among men with high-risk prostate cancers.Prostate cancer is the most commonly diagnosed cancer, and the second leading cause of cancer death among men in the United States. 1 There are nearly 3 million prostate cancer survivors currently living in the United States, accounting for 20% of all cancer survivors, and the number is still increasing with 220,000 new cases diagnosed each year. 2 Despite a generally good prognosis, death from prostate cancer, even for men diagnosed with localized prostate cancer, is still a concern. 3 Although localized prostate cancer is mostly indolent, local progression and distant metastasis can develop over the long term and cause prostate cancer death. 4 In addition, men with high-grade tumors (Gleason score 8-10) are at least four times as likely to die from prostate cancer as men with low-grade tumors (Gleason score 2-6). 5 Although data are still limited, a growing number of studies suggest that longterm postdiagnosis diet plays a role in prostate cancer progression and eventually prostate cancer mortality. [6][7][8][9] Lycopene, found predominantly in tomato products, is a major carotenoid widely distributed in the human body. Lycopene accumulates in several key organs including the prostate gland. 10 Lycopene is hypothesized to have anticarcinogenic effects primarily due to its antioxi...

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“…Higher lycopene dietary intake was inversely associated with total prostate cancer and with angiogenic potential, suggesting a reduction of the aggressive potential of prostate cancer (Zu et al, 2014). The use of lycopene extracts as a supplement has been compared to the consumption of lycopene in the form of whole food sources, and it has been concluded that in the case of cardiovascular risk factors, tomato intake was more favorable with the exception of blood pressure management (Burton-Freeman and Sesso, 2014).…”

Section: Introductionmentioning

confidence: 99%

New opportunities for developing tomato varieties with enhanced carotenoid content

Leiva-Brondo

Valcárcel

Martí

et al. 2016

Sci. agric. (Piracicaba, Braz.)

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The development of varieties with a high content of antioxidant compounds, such as carotenoids, has become a major focus in the marketing of tomato. Several mutants have been used in the development of high pigment varieties, but the significant influence of the environment on carotenoid content and the presence of negative side effects in vegetative growth and yield have limited the success of these variants. Consequently, the identification of alternative sources of variation in the quest for high carotenoid content is ongoing. In this study, 12 accessions of Solanum lycopersicum (including the former var cerasiforme) and S. pimpinelifolium

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Dietary Lycopene, Angiogenesis, and Prostate Cancer: A Prospective Study in the Prostate-Specific Antigen Era

Cited by 191 publications

References 40 publications

Low-lycopene containing tomato powder diet does not protect against prostate cancer in TRAMP mice

Low-lycopene containing tomato powder diet does not protect against prostate cancer in TRAMP mice

Lycopene, tomato products and prostate cancer‐specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort

New opportunities for developing tomato varieties with enhanced carotenoid content

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