Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers

Sarker, Touhiduzzaman; Wan, Xiaoli; Yang, Haiming; Wang, Zhiyue

doi:10.3390/ani11113165

Cited by 30 publications

(27 citation statements)

References 64 publications

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“…In the present study, AFB 1 significantly increased the concentrations of MDA and decreased the antioxidant enzyme activities of T-SOD, GSH-Px, GST, and CAT in the liver, jejunum, and the plasma of broilers when compared with the CON. These results are in consistent with previous studies, which demonstrated that different dosage of AFB 1 decreased the activity of antioxidant enzymes, increased the lipid peroxidation, and inhibited the antioxidant capacity of broilers (14,15,54,55). Recently, researchers have been interested in the usage of antioxidants to counter the toxic effects of aflatoxins (56).…”

Section: Discussionsupporting

confidence: 92%

Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1

Chen

Guo

et al. 2022

Front. Vet. Sci.

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A total of 480 one-day-old AA broiler chicks were randomly allocated to one of four treatments in a 2 × 2 factorial to investigate the effects of tannic acid (TA) on growth performance, relative organ weight, antioxidant capacity, and intestinal health in broilers dietary exposed to aflatoxin B1 (AFB1). Treatments were as follows: (1) CON, control diet; (2) TA, CON + 250 mg/kg TA; (3) AFB1, CON + 500 μg/kg AFB1; and (4) TA+AFB1, CON + 250 mg/kg TA + 500 μg/kg AFB1. There were 10 replicate pens with 12 broilers per replicate. Dietary AFB1 challenge increased the feed conversion ratio during days 1 to 21 (P < 0.05). The TA in the diet did not show significant effects on the growth performance of broilers during the whole experiment period (P > 0.05). The liver and kidney relative weight was increased in the AF challenge groups compared with the CON (P < 0.05). The addition of TA could alleviate the relative weight increase of liver and kidney caused by AFB1 (P < 0.05). Broilers fed the AFB1 diets had lower activity of glutathione peroxidase, catalase, total superoxide dismutase, S-transferase, and total antioxidant capacity in plasma, liver and jejunum, and greater malondialdehyde content (P < 0.05). Dietary supplemented with 250 mg/kg TA increased the activities of antioxidative enzymes, and decreased malondialdehyde content (P < 0.05). In addition, AFB1 significantly reduced the villus height and crypt depth ratio in the ileum on day 42 (P < 0.05). In conclusion, supplementation with 250 mg/kg TA could partially protect the antioxidant capacity and prevent the enlargement of liver in broilers dietary challenged with 500 μg/kg AFB1.

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Section: Discussionsupporting

confidence: 92%

Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1

Chen

Guo

et al. 2022

Front. Vet. Sci.

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“…The recommended Mn content for broilers is 120 mg/kg during 1–3 weeks and 100 mg/kg during 4–6 weeks by the Feeding Standard of Chicken in China. Additionally, we searched recent related articles on broiler experiments in Animals and also found that the amount of added Mn in the diet was around 100 mg/kg [ 18 , 19 , 20 , 21 , 22 ]. So we added 100 mg/kg Mn in the form of MnSO 4 as the positive control.…”

Section: Methodsmentioning

confidence: 99%

Effects of Manganese Hydroxychloride on Growth Performance, Antioxidant Capacity, Tibia Parameters and Manganese Deposition of Broilers

Sun

Geng

Yuan

et al. 2021

Animals

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This study was conducted to investigate the effects of dietary supplementation with manganese hydroxychloride (MHC) on production performance, antioxidant capacity, tibial quality, and manganese (Mn) deposition of broilers. A total of 756 one-day-old male Arbor Acres broilers were randomly allotted to 7 treatments of 6 replicates with 18 broilers per replicate. Broilers were fed corn-soybean meal basal diets supplemented of 100 mg/kg Mn as Mn sulfate (MnSO4), or 0, 20, 40, 60, 80, 100 mg/kg Mn as MHC for 42 days. The growth performance of broilers was not affected by dietary MnSO4 or MHC (p > 0.05), whereas the dressing percentage increased linearly (p < 0.05) with increasing of dietary MHC addition level. The activities of catalase (CAT) and manganese superoxide dismutase (MnSOD), and total antioxidant capability (T-AOC) in serum and liver on day 42 increased linearly (p < 0.05) with increasing of dietary MHC level, while malondialdehyde (MDA) concentration reduced linearly (p < 0.05). The length, strength, and density index of tibia increased linearly (p < 0.05) on day 21 as MHC supplementation level increased; there were no differences between MnSO4 group and 40–100 mg/kg Mn as MHC groups in tibial parameters of broilers (p > 0.05). As supplemental MHC levels increased, the Mn contents in heart, liver, kidney, and tibia increased linearly on day 42 (p < 0.05). In summary, dietary supplementation with MHC improved antioxidant capacity, bone quality, and Mn contents in broilers, but no effects on growth performance were detected. Based on the results of this study, dietary inclusion of 50–90 mg/kg Mn in the form of MHC to broilers is recommended.

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“…Corn treated with lycopene increased the level of immunoglobulin G in sheep's blood, which facilitated passive immunity transfer to newborn lambs (Fallah et al 2021). Dietary lycopene supplementation may increase antioxidant activity and ameliorate AFB1-induced intestinal immune function and barrier function impairment in the intestinal mucosa (Sarker et al 2021). In diabetic rats, lycopene has anti-anemic properties and improves immunity.…”

Section: A Dysfunctional Immune Response To Covid-19 Could Be Enhance...mentioning

confidence: 99%

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

et al. 2022

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Lycopene is a group of phytochemicals found in nature, primarily in fruits and vegetables. Lycopene is thought to protect against a variety of diseases attributed to its antioxidant capabilities. Lycopene has anti-inflammatory, anti-cancer, and immunity-boosting qualities, among other biological and pharmacological benefits. COVID-19 (coronavirus disease 19) is an infectious disease caused by the SARS-CoV-2 virus, which has recently emerged as one of the world's leading causes of death. Patients may be asymptomatic or show signs of respiratory, cytokine release syndrome, gastrointestinal, or even multiple organ failure, all of which can lead to death. In COVID-19, inflammation, and cytokine storm are the key pathogenic mechanisms, according to SARS-CoV-2 infection symptoms. ARDS develops in some vulnerable hosts, which is accompanied by an inflammatory "cytokine syndrome" that causes lung damage. Immunological and inflammatory markers were linked to disease severity in mild and severe COVID-19 cases, implying that inflammatory markers, including IL-6, CRP, ESR, and PCT were significantly linked with COVID-19 severity. Patients with severe illness have reduced levels of several immune subsets, including CD4 + T, NK, and CD8 + cells. As a result, lycopene can be commended for bolstering physiological defenses against COVID-19 infections

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Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers

Cited by 30 publications

References 64 publications

Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1

Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1

Effects of Manganese Hydroxychloride on Growth Performance, Antioxidant Capacity, Tibia Parameters and Manganese Deposition of Broilers

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

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