Dietary phosphorus depletion in sheep: effects on plasma inorganic phosphorus, calcium, l,25-(OH)<sub>2</sub>-Vit.D<sub>3</sub>and alkaline phosphatase and on gastrointestinal P and Ga balances

Breves, Gerhard; Ross, R.; Höller, H.

doi:10.1017/s0021859600059530

Cited by 49 publications

(37 citation statements)

References 20 publications

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“…1 23 g P d-1 or 29 % of daily P intake. This quantity would also be equivalent to more than 30 % of inorganic phosphate which was found to be absorbed from the entire small intestine of comparable sheep under the same dietary treatment (Breves et al 1985). Even this high absorptive capacity of the reticulo-rumen appears to be underestimated because, in the present experiments, only 2 1 of buffer fluid were introduced into the isolated organ whereas the normal rumen fluid volume in these sheep was between 5 and 6 1.…”

Section: Discussionmentioning

confidence: 55%

“…In almost all balance studies with sheep cannulated in the proximal duodenum a preduodenal phosphate net secretion has been found which was in the range between 1 and 5 g d-', obviously dependent upon daily P supply, and due to salivary inflow (Bruce, Goodall, Kay, Phillipson & Vowles, 1966;Pfeffer, 1968;Pfeffer, Thompson & Armstrong, 1970;Kay & Pfeffer, 1970;Grace, Ulyatt & MacRae, 1974; Tagari, Zamwel & Bondi, 1975;Thewis, Francois & Thielemans, 1978;Dillon & Scott, 1979; Ben-Ghedalia, Tagari & Geva, 1982;Greene, Webb & Fontenot, 1983;Breves, Ross & Holler, 1985; Thewis & Francois, 1985;Wylie, Fontenot & Greene, 1985). Since the amount of P secreted with saliva was not measured in these studies a possible net absorption of phosphate from the forestomachs and the abomasum was not detected.…”

Section: Introductionmentioning

confidence: 99%

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FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

Breves¹,

Höller²,

Packheiser³

et al. 1988

Exp Physiol

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SUMMARYExperiments were done in vivo and in vitro to study the flux of inorganic phosphate (Pi) across the rumen wall in sheep. The technique of the temporarily isolated and washed reticulo-rumen was applied to measure Pi net flux at nine different Pi concentrations in the buffer solutions introduced into the reticulo-rumen for 1 h. Six sheep were either P replete (4-25 g P d-l) or in a P-depleted state (1-05 g P d-1). Under both dietary treatments Pi net secretion into the reticulorumen was found at Pi concentrations between 0 1 and 2-2 mmol 1-1 whereas Pi net absorption was observed at P, concentrations between 4-1 and 15 8 mmol 1-1. There

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

Breves¹,

Höller²,

Packheiser³

et al. 1988

Exp Physiol

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“…It should be noted that the level of bone-specific alkaline phosphatase in the circulation will be related to a combination of the activity of individual osteoblasts and the extent of the bone surface covered by active boneforming cells. Previous studies in lambs fed low P diets failed to detect any change in serum or plasma ALP levels (Breves et al 1985;Corlett & Care, 1988). These, however, were estimates of total activity rather than of the bone-specific isoenzyme.…”

Section: Discussionmentioning

confidence: 81%

Effect of diets varying in nitrogen or phosphorus content on indicators of bone growth in lambs

Scott¹,

Loveridge²,

Nicodemo³

et al. 1997

Experimental Physiology

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SUMMARYGrowing lambs were fed diets low in nitrogen and phosphorus (LNLP), low in nitrogen and high in phosphorus (LNHP), high in nitrogen and low in phosphorus (HNLP) or high in nitrogen and phosphorus (HNHP) and the effects on bone growth and on blood and urinary bone marker levels or excretion rates were monitored. Plasma calcium concentrations were higher, and phosphorus concentrations lower, in lambs fed the low phosphorus diets but there were no differences in plasma 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) concentrations. Lambs fed both low phosphorus diets (LNLP and HNLP) had lower plasma osteocalcin and higher bone-specific alkaline phosphatase concentrations than those fed the high phosphorus diets. Urinary pyridinoline and deoxypyridinoline excretion were also affected by treatment, with their rates of excretion being highest in lambs fed the diet low in both nitrogen and phosphorus (LNLP). Lambs fed the low phosphorus diets were lighter in weight at slaughter and had lighter bones that were less well mineralized than those fed the high phosphorus diets. Reducing the nitrogen content of the diet appeared to have little effect on bone composition. These results suggest that bone markers that have proved useful in the diagnosis and treatment of bone disease are sensitive to variation in nutrient supply and may prove useful in the early detection of nutrient deficiencies that affect bone growth.

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“…A elevação do Ca plasmático na deficiência de P é relatada com freqüência na literatura (BREVES et al, 1985;TERNOUTH e SEVILLA, 1990) e pode estar ligada ao aumento da reabsorção óssea e/ou à redução na formação de osso (SCOTT et al, 1997).…”

Section: Nicodemo Et Alunclassified

Uso de parâmetros ósseos, plasmáticos e fecais na determinação da deficiência de fósforo em bovinos

et al. 2000

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RESUMO -Quinze novilhos Nelore foram distribuídos em três tratamentos, consistindo de dieta basal capaz de proporcionar ganhos da ordem de 600 g/dia, suplementada (15 ou 11 g P/dia) ou não (5 g P/dia) com fosfato monoamônico, para determinar as alterações provocadas por deficiência de P em parâmetros ósseos, sangüíneos e fecais. Biópsias de costela foram obtidas aos 60 e 250 dias de experimentação. Amostras de plasma foram coletadas quinzenalmente e amostras de fezes retais, analisadas em sete ocasiões, durante os 250 dias do experimento. Coleta total (diária) de fezes foi feita em dois períodos, aos 60 e 243 dias, durante sete dias. Aos 60 dias, P expresso em relação ao osso fresco, osso seco e desengordurado e ao volume de osso discriminaram entre os tratamentos. Aos 250 dias, a espessura da camada cortical e as concentrações de cinzas e fósforo foram reduzidas na deficiência de P. Observou-se queda na concentração de fósforo inorgânico plasmático (Pi), já aos 12 dias de experimentação, apresentando valores em torno de 3,0 mg % na época em que ganho de peso foi afetado (82 dias). Foi observada elevação do Ca e da fosfatase alcalina na deficiência de P, sem alterações na concentração de hidroxiprolina do plasma. As concentrações de P nas fezes aumentaram com a concentração do elemento na dieta, mas a utilização de amostras coletadas do reto não propiciou detecção precoce de deficiência de P. A definição de níveis críticos para a determinação de deficiência apresentou problemas.Palavras-chave: bovinos, deficiência, fósforo, níveis críticos, osso, plasma Use of Bone, Plasma and Feces in the Assessment of P Status in CattleABSTRACT -Fifteen Nellore steers were allotted to three treatments, consisting of a basal diet, which will be able to provide gains of about 600 g/day, supplemented (15 or 11 g P/day) or not (5 g P/day) with monoammonium phosphate in order to evaluate the alterations in bone, plasma and fecal measurements due to P deficiency. Rib biopsies were taken at 60 and 250 days of trial, plasma samples were taken every 15 days, and fecal grab samples were analyzed in seven occasions along the trial. Total daily fecal collection was performed in two occasions, at 60 and 243 days of the trial, for seven days. At day 60, P expressed as fresh bone, dried defatted bone and bone volume were able to detect treatment differences. At day 250, cortical thickness, P and ash concentrations were reduced in P deficiency. Plasma inorganic P (Pi) was lower at 12 days of trial, with values close to 3,0 mg % at the time where daily weight gain was affected (day 82). Calcium and total alkaline phosphatase increased in P deficiency, without changes on the plasma hidroxyproline concentration. Fecal P concentrations increased as the dietary P concentrations increased, but grab samples did not allow early detection of P deficiency. The definition of critical P levels for the determination of deficiency showed problems.

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Dietary phosphorus depletion in sheep: effects on plasma inorganic phosphorus, calcium, l,25-(OH)₂-Vit.D₃and alkaline phosphatase and on gastrointestinal P and Ga balances

Cited by 49 publications

References 20 publications

FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

Effect of diets varying in nitrogen or phosphorus content on indicators of bone growth in lambs

Uso de parâmetros ósseos, plasmáticos e fecais na determinação da deficiência de fósforo em bovinos

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Dietary phosphorus depletion in sheep: effects on plasma inorganic phosphorus, calcium, l,25-(OH)2-Vit.D3and alkaline phosphatase and on gastrointestinal P and Ga balances

Cited by 49 publications

References 20 publications

FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

FLUX OF INORGANIC PHOSPHATE ACROSS THE SHEEP RUMEN WALL IN VIVO AND IN VITRO

Effect of diets varying in nitrogen or phosphorus content on indicators of bone growth in lambs

Uso de parâmetros ósseos, plasmáticos e fecais na determinação da deficiência de fósforo em bovinos

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Dietary phosphorus depletion in sheep: effects on plasma inorganic phosphorus, calcium, l,25-(OH)₂-Vit.D₃and alkaline phosphatase and on gastrointestinal P and Ga balances