Dietary polyphenols as photoprotective agents against UV radiation

Hu, Shuting; Zhang, Xinchen; Chen, Feng; Wang, Mingfu

doi:10.1016/j.jff.2017.01.009

Cited by 49 publications

(27 citation statements)

References 103 publications

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“…Many dietary compounds have been identified: vitamins, minerals, carotenoids and a large class of phytochemicals (polyphenols, isothiocyanates, organosulfur compounds), as well as sulforaphane, anthocyanidins, lycopene, diallyl disulfide, rosmarinic acid, silymarins, oleuropein, etc. [25, 26]. Both in vitro and in vivo studies have elucidated various cellular and molecular mechanisms by which such compounds scavenge ROS and act against melanoma cell formation; we will focus initially on coffee, tea and pomegranate, and then in specific dietary compounds in which consistent advances were carried out in the last decade.…”

Section: Foods and Melanoma Risk: Recent Advancesmentioning

confidence: 99%

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

et al. 2019

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Cutaneous malignant melanoma is a heterogeneous disease, being the consequence of specific genetic alterations along several molecular pathways. Despite the increased knowledge about the biology and pathogenesis of melanoma, the incidence has grown markedly worldwide, making it extremely important to develop preventive measures. The beneficial role of correct nutrition and of some natural dietary compounds in preventing malignant melanoma has been widely demonstrated. This led to numerous studies investigating the role of several dietary attitudes, patterns, and supplements in the prevention of melanoma, and ongoing research investigates their impact in the clinical management and outcomes of patients diagnosed with the disease. This article is an overview of recent scientific advances regarding specific dietary compounds and their impact on melanoma development and treatment.

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Section: Foods and Melanoma Risk: Recent Advancesmentioning

confidence: 99%

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

et al. 2019

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“…As a consequence of their amphiphilic properties, plant polyphenols can act as hydrophilic or lipophilic scavengers functioning in different cell compartments. Apart from antioxidant activity, polyphenols (especially isoflavones and flavonoids) display additional biochemical activities, such as enzyme inducers or inhibitors, and impact cell division and anti-inflammatory pathways [25,26]. As indicated, polyphenols inhibit UV-dependent activation of mitogen-activated protein kinases (MAPK) and AP-1 [27].…”

Section: Antioxidantsmentioning

confidence: 99%

Agro-Industrial By-Products and Their Bioactive Compounds—An Ally against Oxidative Stress and Skin Aging

Simitzis

2018

Cosmetics

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The increased consumer awareness towards hazards related with sun exposure has given a boost in the cosmetics industry and particularly the sun care market. Human skin is continually being threatened by the UV irradiation present in sunlight and acute UV exposure leads to skin photoaging. Cosmetic and/or dermatological applications include several bioactive compounds that contribute to the regulation of epidermal homeostasis by providing protection against solar radiation and improving the antioxidant activity of epidermis. Plant extracts are sources of active ingredients with intense therapeutic properties, and the topical application or oral intake of these compounds could ameliorate skin condition. Nowadays, there is a growing demand for the application of the bioactive agents contained in agro-industrial byproducts in sun care products, since many of them have shown promising properties as skin photoprotectants. However, well-conducted clinical studies are required to prove their safety and efficacy before they could be regularly used. Environmentally friendly extraction and sustainable techniques are therefore under examination for recovering such compounds from agro-industrial byproducts and converting them into innovative high-value natural ingredients used in cosmetic formulations.

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“…Silybum marianum, also known as milk thistle, is a famous medicinal plant that has traditionally been used for detoxification and for treating liver disease [6]. Silibinin is the major active component in silymarin, an extract of S. marianum that contains a mixture of flavonolignans, including that of silibinin, isosilibinin, silicristin, silidianin, and others [7]. It has been reported that silibinin has many biological activities, such as antioxidant effect and anticancer effects by inducing cell cycle arrest and apoptosis in human carcinoma cells [8].…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Depletion by Silibinin Stimulates Apoptosis-Like Death in Escherichia coli

Liu

Lee

2017

Journal of Microbiology and Biotechnology

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Silibinin is the major active component of silymarin, extracted from the medicinal plant . Silibinin has potent antibacterial activity; however, the exact mechanism underlying its activity has not been elucidated. Here, we investigated the novel mechanism of silibinin against Escherichia coli. Time-kill kinetic assay showed that silibinin possess a bactericidal effect at minimal inhibitory concentration (MIC) and higher concentrations (2- and 4-fold MIC). At the membrane, depolarization and increased intracellular Ca²⁺ levels were observed, considered as characteristics of bacterial apoptosis. Additionally, cells treated with MIC and higher concentrations showed apoptotic features like DNA fragmentation, phosphatidylserine exposure, and caspase-like protein expression. Generally, apoptotic death is closely related with ROS generation; however, silibinin did not induce ROS generation but acted as a scavenger of intracellular ROS. These results indicate that silibinin dosedependently induces bacterial apoptosis-like death, which was affected by ROS depletion, suggesting that silibinin is a potential candidate for controlling bacteria.

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Dietary polyphenols as photoprotective agents against UV radiation

Cited by 49 publications

References 103 publications

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

Agro-Industrial By-Products and Their Bioactive Compounds—An Ally against Oxidative Stress and Skin Aging

Reactive Oxygen Species Depletion by Silibinin Stimulates Apoptosis-Like Death in Escherichia coli

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