Dietary polyphenols can modulate the intestinal inflammatory response

Abstract

Inflammatory bowel diseases (IBD) arise from multiple causes, including environmental factors, gut microflora, immunity, and genetic predispositions. In the course of IBD, immune homeostasis and intestinal mucosa barrier integrity are impaired. Among natural preventive treatments that have been identified to date, polyphenols appear as promising candidates. They have been shown to protect against several diseases, including cardiovascular diseases and cancers, and they have anti-inflammatory properties in non-intestinal models. This paper will review the literature that has described to date some effects of polyphenols on intestinal inflammation. Studies, conducted using in vivo and in vitro models, provide evidence that pure polyphenolic compounds and natural polyphenolic plant extracts can modulate intestinal inflammation.

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

“…Using IEC lines derived from human colon cancer, most of the polyhenols that were examined proved to significantly quench, at various levels, NF-jB activation and nuclear translocation pathway, and also to down-regulate the synthesis and secretion of inflammatory cytokines, including IL-6, IL-8, and monocyte chemotactic protein-1 (MCP-1). However, genistein and a few other flavonoids gave controversial results, and resveratrol even appeared to up-regulate IL-8 secretion by colonic cells (217). The findings of a large number of studies on animals with experimental colitis, concerning the anti-inflammatory and overall protective action of polyphenols, are more consistent.…”

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

“…Daily intake is estimated at 100-150 mg per day in Western populations (Manach et al, 2004). Polyphenol consumption has been implicated to have diverse benefits such as improved gut health and reduced risk of coronary heart disease, amongst others (Fava et al, 2006;Romier et al, 2009). However, despite mechanistic evidence for these potential effects, in most cases they are far from being clearly proven.…”

Mango (Mangifera indica cv. Azucar) antiinflammatory and chemopreventive role during colorectal carcinogenesis

“…Then, the accumulation of bioactive compounds reached in gut of mice who received mango juice in our study (AOM, mango 0.3%) could not be enough to reduce the systemic cytokines levels (Neilson et al, 2011;Cilla et al, 2009;Romier et al, 2009). Nonetheless, it is remarkable that intact or modified phytochemicals from mango were enough to act locally and control carcinogenesis halting ACF formation in the experimental group (AOM, mango 0.3%).…”