Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

Yokoyama, Meiko; Tanigawa, Kanae; Murata, Toshiaki; Kobayashi, Yukiko; Tada, Eriko; Suzuki, Isao; Nakabou, Yukihiro; Kuwahata, Masashi; Kido, Yasutoshi

doi:10.1016/j.nutres.2010.03.002

Cited by 21 publications

(19 citation statements)

References 41 publications

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“…The adverse effects of dietary saturated fats on kidney function, however, are supported by several recent studies. Streptozotocin-induced diabetic rats fed a lard diet containing high amounts of saturated fats for 11 days showed elevated levels of plasma ketone, total cholesterol, and triglycerides compared with rats fed a diet where the fat content of lard was replaced by PUFA-rich rapeseed oil (154). The lard-fed animals had higher albuminuria and renal triglyceride levels, with a positive correlation between these two factors.…”

Section: A High-fat Diet As a Risk Factor For Ckdmentioning

confidence: 91%

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt

2011

American Journal of Physiology-Renal Physiology

218

128

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The Western-style diet is characterized by its highly processed and refined foods and high contents of sugars, salt, and fat and protein from red meat. It has been recognized as the major contributor to metabolic disturbances and the development of obesity-related diseases including type 2 diabetes, hypertension, and cardiovascular disease. Also, the Western-style diet has been associated with an increased incidence of chronic kidney disease (CKD). A combination of dietary factors contributes to the impairment of renal vascularization, steatosis and inflammation, hypertension, and impaired renal hormonal regulation. This review addresses recent progress in the understanding of the association of the Western-style diet with the induction of dyslipidemia, oxidative stress, inflammation, and disturbances of corticosteroid regulation in the development of CKD. Future research needs to distinguish between acute and chronic effects of diets with high contents of sugars, salt, and fat and protein from red meat, and to uncover the contribution of each component. Improved therapeutic interventions should consider potentially altered drug metabolism and pharmacokinetics and be combined with lifestyle changes. A clinical assessment of the long-term risks of whole-body disturbances is strongly recommended to reduce metabolic complications and cardiovascular risk in kidney donors and patients with CKD.

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Section: A High-fat Diet As a Risk Factor For Ckdmentioning

confidence: 91%

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt

2011

American Journal of Physiology-Renal Physiology

218

128

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“…Furthermore, other studies have reported that some compounds, even known as beneficial food materials, can worsen a disease condition (7,8). These reports suggest that careful considerations are required to understand the correct use of these food materials and evaluate their effects on both biochemical parameters and organ morphology.…”

Section: Abstract Background/aim: Metabolic Syndrome-induced Lifestymentioning

confidence: 99%

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

Naito

Yoshikawa

Yoshizawa

et al. 2017

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Abstract. Background/Aim: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato) Zn, [Zn(hkt) 2 The westernization of eating habits has increased the intake of fat. Metabolic syndrome, which is caused by these changing dietary habits, induces diabetes mellitus (DM) or hypertension (1, 2). There are numerous reports on the effects of a high-fat diet (HFD) intake on health, and the most serious and important are dyslipidaemia, which is characterised by hypertriglyceridaemia, hypercholesterolaemia, and fatty liver (3, 4).Numerous researchers have reported the effects of many organic or inorganic compounds on various organs, leading to disorders such as fatty liver or diabetic nephropathy (5, 6). Furthermore, other studies have reported that some compounds, even known as beneficial food materials, can worsen a disease condition (7,8). These reports suggest that careful considerations are required to understand the correct use of these food materials and evaluate their effects on both biochemical parameters and organ morphology. In particular, dyslipidaemia, which is a risk factor for cardiovascular disease, should be prevented.Pioglitazone is known to exhibit efficacy in the treatment of DM owing to its blood glucose lowering, glycated haemoglobin (HbA1c) improvement, and glucose tolerance ameliorating effects (9, 10). Furthermore, numerous researchers have reported the anti-DM effect of Zn in in vivo experiments (11-13). For example, Zn compound 1) increased Akt-phosphorylation, as well as inhibited tyrosine-protein phosphatase non-receptor type 1B (PTP1B) and phosphatase and tensin homolog (PTEN) in 3T3-L1 adipocytes; and 2) inhibited alpha-glucosidase and 3) activated phosphodiesterase (14-18). Furthermore, only a few studies such as that of Moroki et al. (19) have reported experiments showing the effects of Zn complexes on lipid metabolism. Thus, the effects of Zn compounds on lipid metabolism have not been sufficiently examined yet.The experimental animals were fed an HFD or highfructose diet to establish the metabolic syndrome or DM model (20,21). Therefore, this study examined the histopathology of the livers and kidneys of C57BL/6J mice 1145

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“…Several cross-sectional studies of patients with type 1 diabetes have indicated that elevated apolipoprotein B or LDL-cholesterol and/or decreased levels of HDL-cholesterol are associated with progression of albuminuria [6][7][8][9][10]. Moreover, experiments in animal models of diabetes fed a Western diet have also supported the notion that sustained lipid abnormalities accelerate the progression of DN [11][12][13][14].…”

Section: Introductionmentioning

confidence: 97%

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice

et al. 2013

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Aims/hypothesis Liver X receptors (LXRs) α and β are nuclear hormone receptors that are widely expressed in the kidney. They promote cholesterol efflux from cells and inhibit inflammatory responses by regulating gene transcription. Here, we hypothesised (1) that LXR deficiency would promote renal decline in a mouse model of diabetes by accelerating intraglomerular cholesterol accumulation and, conversely, (2) that LXR agonism would attenuate renal decline in diabetes.Methods Diabetes was induced with streptozotocin (STZ) and maintained for 14 weeks in Lxrα/β +/+ (Lxrα, also known as Nr1h3; Lxrβ, also known as Nr1h2) and Lxrα/β −/− mice. In addition, STZ-injected DBA/2J mice were treated with vehicle or the LXR agonist N ,N -dimethyl-hydroxycholenamide (DMHCA) (80 mg/kg daily) for 10 weeks. To determine the role of cholesterol in diabetic nephropathy (DN), mice were placed on a Western diet after hyperglycaemia developed. Results Even in the absence of diabetes, Lxrα/β −/− mice exhibited a tenfold increase in the albumin:creatinine ratio and a 40-fold increase in glomerular lipid accumulation compared with Lxrα/β +/+ mice. When challenged with diabetes, Lxrα/β −/− mice showed accelerated mesangial matrix expansion and glomerular lipid accumulation, with upregulation of inflammatory and oxidative stress markers. In the DN-sensitive STZ DBA/2J mouse model, DMHCA treatment significantly decreased albumin and nephrin excretion (by 50% each), glomerular lipids and plasma triacylglycerol (by 70%) and cholesterol (by 48%); it also decreased kidney inflammatory and oxidative stress markers compared with vehicle-treated mice. Conclusions/interpretation These data support the idea that LXR plays an important role in the normal and diabetic kidney, while showing that LXR, through its inhibitory effect on inflammation and cholesterol accumulation in glomeruli, could also be a novel therapeutic target for DN.

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Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

Cited by 21 publications

References 41 publications

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice

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